Clinical trials: Norepinephrine
Shock, Intensive Care
CHangeovers of Norepinephrine in Intensive Care
CHIC study's purpose is to compare the efficiency, in terms of blood pressure stability, of three changeovers of norepinephrine used routinely in ICU. The three techniques are: Quick change Double pumping Smart infusion pumps
- Trial name
- CHIC (NCT02304939)
- Testing
- changeover, use of automatic infusion pump, datas collection
- Where
- France
- Volunteers
- 285 people
- Sponsor
- University Hospital, Angers
Septic Shock
Hemodynamic Effects of Dexmedetomidine in Septic Shock
The current treatment regimen of patients with septic shock requires a sufficient hemodynamic support aiming to preserve tissue oxygen requirements and perfusion.
- Trial name
- NCT02638545
- Testing
- Dexmedetomidine
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- University of Roma La Sapienza
Anxiety Disorder
Duloxetine for Social Anxiety Disorder: Prediction of Long Term Outcome
The purpose of this study is to examine the safety and efficacy of duloxetine for the treatment of social anxiety disorder.
- Trial name
- NCT00114127
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes
SGLTi, Hepatic Glucose Production and Ketogenesis
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and…
- Trial name
- NCT05960656
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Chronic Kidney Disease
Serotonin Norepinephrine Reuptake Inhibitors and the Risk of Serious Adverse Events
This is a population-based retrospective, new-user design, active comparator cohort study assessing whether initiating a new outpatient prescription of high-dose serotonin norepinephrine reuptake inhibitors (SNRIs)-venlafaxine…
- Trial name
- NCT07531173
- Testing
- Venlafaxine or duloxetine
- Volunteers
- 8,688 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hypertension
Effect of Vasopressin vs Norepinephrine on Pulmonary Oxygenation and Lung Mechanics in Patients With Hypertension Therapy During One-lung Ventilation : Preliminary Study
Hypotension during anesthesia often occurs because reduced systemic vascular resistance and blocked sympathetic nervous system by anesthetic drugs.
- Trial name
- NCT04170751
- Testing
- 16 mcg / cc of norepinephrine(group N), 0.4 unit / cc of vasopressin(group V)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Anesthesia, Surgery
Norepinephrine vs Phenylephrine During General Anesthesia
50 million patients undergo surgery each year in the United States. Postoperative mortality is considered the third leading cause of death worldwide.
- Conditions
- Anesthesia, Surgery, Hypotension
- Trial name
- VEGA-1 (NCT04789330)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 5 sites in United States
- Volunteers
- 3,626 people
- Sponsor
- University of California, San Francisco
Intraoperative Hypotension
Continuous Versus Bolus Administration of Norepinephrine to Treat Hypotension During Anesthetic Induction
Intraoperative hypotension is common in patients having non-cardiac surgery with general anesthesia and is associated with organ injury and death.
- Trial name
- INDUCT (NCT05940649)
- Testing
- Continuous norepinephrine administration
- Where
- Germany
- Volunteers
- 262 people
- Sponsor
- Kristen Thomsen
Late-Onset Neonatal Sepsis, Extreme Prematurity
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
Fluid-unresponsive hypotension needing cardiotropic drug treatment is a serious complication in very preterm neonates with suspected late-onset sepsis (LOS; defined as culture positive or negative bloodstream infection or…
- Conditions
- Late-Onset Neonatal Sepsis, Extreme Prematurity, Neonatal Hypotension
- Trial name
- NCT05347238
- Testing
- Dopamine, Norepinephrine
- Where
- 22 sites in United States, Canada and 3 more
- Volunteers
- 550 people
- Sponsor
- Mount Sinai Hospital, Canada
Depressive Disorder, Hormone Disturbance
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.
The hypothesis of a link between depression and Hypothalamic-Pituitary Axis (HPA) dysfunction is now experienced. Since a first description in 1949 this link has made the HPA one of the most investigated hormonal axis in…
- Trial name
- NCT03491696
- Testing
- Metyrapone
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Centre Hospitalier Rouffach
Heart Failure, Obstructive Sleep Apnea
ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
Obstructive sleep apnea (OSA), central sleep apnea (CSA) and heart failure (HF) are states of metabolic demand and sympathetic nervous system (SNS) activation.
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Central Sleep Apnea
- Trial name
- AMEND (NCT02116140)
- Testing
- [C11]Acetate and HED PET
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Arterial Hypotension
Effect of Phenylephrine Versus Norepinephrine on Venous Return
Induction of general anesthesia often induces a decrease in the mean arterial blood pressure (MAP) caused by arterial and venous dilatation.
- Trial name
- NCT03872570
- Testing
- Phenylephrine, Norepinephrine
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Septic Shock
Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients
1. Assess the impact of midodrine administration on weaning of IV vasopressors 2. Assess the cost effectiveness of using midodrine in critically ill patients
- Trial name
- NCT03911817
- Testing
- Midodrine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Haemorrhagic Shock, Variceal Hemorrhage
Macro and Microcirculatory Effects of the Combination of Norepinephrine and Octreotide for the Treatment of Cirrhotic Patients With Hemorrhagic Shock
Octreotide is used to decrease portal pressure of cirrhotic patients admitted for variceal bleeding. When patients are in haemorrhagic shock, the recommended drug to increase arterial pressure is norepinephrine.
- Trial name
- HemodyNoOc (NCT03891849)
- Testing
- Octreotide Injection
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Ascitic Cirrhosis, Hyperactivation of Sympathetic Nervous System
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients
To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of…
- Trial name
- NCT00356226
- Testing
- clonidine
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- CHU de Charleroi
Incidence of Post-spinal Hypotension
Norepinephrine With Ephedrine Versus Norepinephrine Alone During Spinal Anesthesia for Cesarean Delivery
We hypothesize that the addition of ephedrine to norepinephrine infusion could decrease the incidence of post spinal hypotension(PSH) in parturient undergoing C.S under spinal anesthesia and minimize the changes in heart rate
- Trial name
- NCT07379710
- Testing
- Ephedrine and Norepinephrine infusion, Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 260 people
- Sponsor
- Cairo University
Meniere Disease
Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere's Disease Outcomes
As of yet, the cause of Meniere's disease is uncertain and there is no cure. Given the lack of high level evidence for treatments, we seek to perform a randomized, placebo-controlled, double-blind, crossover, pilot trial of…
- Trial name
- NCT04218123
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Major Depressive Disorder
Lisdexamfetamine Dimesylate in Residual Symptoms and Cognitive Impairment in Major Depressive Disorder.
This study aims to test the effect of a newly-approved stimulant medication, lisdexamfetamine dimesylate (Vyvanse), on specific residual symptoms of depression found in some patients who are undergoing treatment with, but have…
- Trial name
- NCT01148979
- Testing
- Lisdexamfetamine Dimesylate (Vyvanse)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mclean Hospital
Cardiogenic Shock
Assessing Catecholamine Treatment Initiation Options: Norepinephrine vs Dopamine for Cardiogenic Shock
The goal of this multicenter, open-label, randomized clinical trial is to learn whether norepinephrine or dopamine is more effective and safer as the first-line vasoactive drug for treating cardiogenic shock in adults.
- Trial name
- ACTION-CS (NCT07562932)
- Testing
- Norepinephrine, Dopamine Agent
- Where
- South Korea
- Volunteers
- 512 people
- Sponsor
- Chonnam National University Hospital
None (i.e. Healthy Volunteers)
Levomilnacipran in Healthy Males
Levomilnacipran is an antidepressant currently approved in Canada to treat Major Depressive Disorder (MDD). Thirty-six healthy male participants will receive escalating doses of levomilnacipran, duloxetine, or placebo every 7…
- Trial name
- NCT03249311
- Testing
- Levomilnacipran, Duloxetine
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Ottawa