Clinical trials: Norepinephrine Bolus
Hypotension on Induction, Emergency Surgery
5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery
Postinduction hypotension is a frequent intraoperative complication, particularly in emergency abdominal surgery due to factors such as sepsis, hypovolemia, and limited preoperative cardiac assessment.
- Conditions
- Hypotension on Induction, Emergency Surgery, Norepinephrine
- Trial name
- NCT07719075
- Testing
- Norepinephrine 10 mcg, Norepinephrine 5 mcg
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Cairo University
Postspinal Hypotension, Cesarean Delivery
Two Norepinephrine Rescue Bolus Doses for Management of Severe Post-spinal Hypotension During Elective Cesarean Delivery
Maternal hypotension after spinal block is a common complication after subarachnoid block in this population whose incidence reached 60% in many reports.
- Conditions
- Postspinal Hypotension, Cesarean Delivery, Norepinephrine
- Trial name
- NCT05290740
- Testing
- Norepinephrine 5 mcg, Norepinephrine 10 mcg
- Where
- Egypt
- Volunteers
- 158 people
- Sponsor
- Kasr El Aini Hospital
Hypotension, Spinal Anesthesia
10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery
Data regarding the optimum dose of norepinephrine for management of severe maternal hypotension is lacking. A previous report showed that the use of 10-mcg norepinephrine bolus was not superior to the 5-mcg bolus in the…
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Section
- Trial name
- NCT06512415
- Testing
- 10 mcg Norepinephrine, 15 mcg Norepinephrine
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Cairo University
Comparing Ephedrine With Norepinephrine for Mangement Postspinal Hypotension
Effectiveness of Prophylactic Bolus Ephedrine Versus Norepinephrine for Management of Post Spinal Hypotension
This study was conducted to compare the effectiveness of ephedrine versus norepinephrine for management of hypotension after spinal anesthesia for mothers undergoing elective cesarean section
- Trial name
- NCT05522088
- Where
- Ethiopia
- Volunteers
- 84 people
- Sponsor
- Wachemo University
Sepsis
Methylene Blue in Sepsis: A Randomized Controlled Trial
The purpose of this study is to investigate whether the addition of Methylene Blue to the standard treatment of septic shock will reduce vasopressor requirements
- Trial name
- SMURF (NCT00486174)
- Testing
- methylene blue
- Sponsor
- Queen's University
Ephedrine, Norepinephrine
Intermittent Bolus Doses of Phenylephrine, Norepinephrine and Ephedrine for the Management of Spinal Induced Hypotension in Preeclamptic Patients
intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients
- Trial name
- NCT07795710
- Testing
- Group 1 (P), Group 2( N), Group 3( E)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Intraoperative Hypotension
Continuous Versus Bolus Administration of Norepinephrine to Treat Hypotension During Anesthetic Induction
Intraoperative hypotension is common in patients having non-cardiac surgery with general anesthesia and is associated with organ injury and death.
- Trial name
- INDUCT (NCT05940649)
- Testing
- Continuous norepinephrine administration
- Where
- Germany
- Volunteers
- 262 people
- Sponsor
- Kristen Thomsen
Anesthesia, Spinal and Epidural, Adverse Effect
Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia
The purpose of the study is to determine if an intravenous bolus of phenylephrine is more effective compared to an intravenous bolus of norepinephrine associated with crystalloid loading for maintaining blood pressure during a…
- Conditions
- Anesthesia, Spinal and Epidural, Adverse Effect, Hypotension, Complications, Cesarean Section
- Trial name
- NorPN (NCT02854787)
- Testing
- Phenylephrine, Norepinephrine
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Spinal Anesthesia Induced Hypotension
COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial
The goal of this clinical trial is to learn if norepinephrine is more effective than phenylephrine for prevention of spinal anesthesia induced hypotension.
- Trial name
- NCT06836986
- Testing
- Norepinephrine Bolus, Phenylephrine bolus
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Dow University of Health Sciences
Hypotension, Spinal Anesthesia
Norepinephrine or Phenylephrine in Bolus for Hypotension in Cesarean Delivery
This study evaluate the ability of phenylephrine and of noradrenaline to maintain normal systemic arterial blood pressure and heart rate in healthy pregnant women submitted to cesarean section with spinal anesthesia.
- Trial name
- NCT03702400
- Testing
- Phenylephrine 100 mcg, Norepinephrine 5 mcg
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Living Donor Liver Transplantation, Norepinephrine Bolus
Norepinephrine Boluses in Liver Transplantation
We study the efficacy of Norepinephrine boluses on prevention of postreperfusion syndrome during living donor liver transplantation.
- Conditions
- Living Donor Liver Transplantation, Norepinephrine Bolus, Postperfusion Syndrome
- Trial name
- NCT03773276
- Testing
- Norepinephrine boluses
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Hypotension, Hypertension
Norepinephrine ED90 Bolus After Spinal Anesthesia in Cesarean Section
The investigators are aiming to determine what is the effective intravenous dose required of an initial bolus of norepinephrine prior to a maintenance infusion to prevent a 20% decrease in maternal blood pressure from baseline…
- Conditions
- Hypotension, Hypertension, Nausea, Pain
- Trial name
- NCT06574555
- Testing
- Norepinephrine
- Where
- Chile
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Cesarean Section Complications, Spinal Anesthetic Toxicity
Comparison of Two Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Cesarean Delivery
In this study the investigators will compare two doses of norepinephrine bolus (6 mcg and 10 mcg) in management of maternal hypotensive episode after subarachnoid block during Cesarean delivery.
- Trial name
- NCT03792906
- Testing
- Norepinephrine 6 mcg, Norepinephrine 10 mcg, Norepinephrine infusion
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Cairo University
Spinal Anesthetic Toxicity, Hypotension Drug-Induced
Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension
In this study the investigators will compare two doses of norepinephrine bolus (6 mcg and 8 mcg) in management of maternal hypotensive episode after spinal block during cesarean delivery.
- Conditions
- Spinal Anesthetic Toxicity, Hypotension Drug-Induced, Cesarean Section Complications
- Trial name
- NCT05502146
- Testing
- Noradrenaline Bitartrate, Bupivacaine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mersin University
Anesthesia; Adverse Effect, Cesarean Section Complications
Comparison Between Three Norepinephrine Bolus Doses for Management of Post-spinal Hypotension During Ceaserian Section for Patients With Preeclampsia
Maternal hypotension after subarachnoid block is a frequent and deleterious complication during lower segment caesarean section (LSCS). Prophylaxis against hypotension using vasopressors had become a standard recommendation.
- Trial name
- NCT05368415
- Testing
- Norepinephrine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Preeclampsia, Cesarean Birth
Norepinephrine Infusion vs Bolus vs Ephedrine for Blood Pressure Stability During Cesarean Delivery in Women With Preeclampsia
This randomized controlled trial will compare norepinephrine infusion, norepinephrine bolus, and ephedrine bolus for maintaining hemodynamic stability during spinal anesthesia for scheduled cesarean delivery in women with…
- Conditions
- Preeclampsia, Cesarean Birth, Hypotension During Surgery
- Trial name
- NCT07842783
- Testing
- Norepinephrine (0.05 μg/kg/min), Norepinephrine 4mcg, Ephedrine Bolus 6 mg
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Benha University
Postinduction Hypotension
Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk…
- Trial name
- INDUCT-Multi (NCT07538388)
- Testing
- Continuous Norepinephrine Administration
- Where
- 4 sites in Germany
- Volunteers
- 446 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypotenstion, Cesarean Resection
Norepinephrine vs. Phenylephrine for Spinal Hypotension in Cesarean Section
This clinical trial was conducted to compare the effectiveness and safety of two medications-norepinephrine and phenylephrine-in treating low blood pressure (hypotension) that often occurs during spinal anesthesia for cesarean…
- Conditions
- Hypotenstion, Cesarean Resection, Anesthesia Spinal, Pregnancy Complications
- Trial name
- Norepinephrine (NCT07153601)
- Testing
- Norepinephrine 4mcg, Phenylephrine 50 mcg
- Where
- Indonesia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universitas Sumatera Utara