Clinical trials: Normal
System; Lupus Erythematosus
Myofascial Techniques and Proprioceptive Neuromuscular Facilitation in Patients With Systemic Lupus Erythematosus.
Introduction. Systemic lupus erythematosus is an autoimmune disease. The musculoskeletal system is affected in 90% of patients. The most common manifestations are myalgias, arthralgias and arthritis. Objective.
- Trial name
- NCT06383104
- Testing
- Intervention
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Lewy Body Disease, Dementia
MIBG in Aging and Neurologic Disorders
The purpose of the study is to investigate the use of a special radioactive drug called 123I-MIBG and myocardial MIBG scintigraphy.
- Conditions
- Lewy Body Disease, Dementia, Parkinsonism, Mild Cognitive Impairment
- Trial name
- NCT05514106
- Testing
- meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
COVID 19
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects With Renal Impairment and in Healthy Subjects With Normal Renal Function
This is a Phase 1 non-randomized, open-label, multiple dose, parallel-group study of ALG-097558 in subjects with severe renal impairment and subjects without renal impairment, matched for age, body weight and, to the extent…
- Trial name
- NCT06698549
- Testing
- ALG-097558
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
Chronic Periodontitis
Clinical, Anti-Inflammatory And Anti-Infective Properties Of Amniotic Membranes Used For Guided Tissue Regeneration
The objective of this study is to evaluate the anti-inflammatory and anti-infective properties of amniotic membrane (AM) when used for guided tissue regeneration (GTR) in periodontal bone defects.
- Trial name
- NCT02033226
- Testing
- Amniotic Membrane, Control group (Hydroxyapatite only)
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Type 2 Diabetes Mellitus With Circulatory Complciation
Association of Carbamylated HDL and CAD in T2DM Patients
This is an observational cross-sectional study aimed at investigating the alterations of the carbamylated-HDL levels in T2DM patients, and comparing the concentration of carbamylated-HDL between the T2DM patients with CAD and…
- Trial name
- NCT04390711
- Testing
- High density lipoprotein isolation, detection and in-vitro study.
- Where
- China
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Premature Ovarian Failure
Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency
60 cases with premature ovarian insufficiency will be randomized to either receive PRP or saline injection in their ovaries. Then follow up by hormonal \& ultrasound \& clinically to monitor any changes
- Trial name
- NCT04922398
- Testing
- platelet rich plasma, Normal saline
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ahmed Saad
Breast Cancer, Pain
The Effect of Music on Pain, Anxiety and Satisfaction During Mammography
This study was planned to determine the effect of music listened to during mammography screening on pain, anxiety and satisfaction.
- Conditions
- Breast Cancer, Pain, Anxiety
- Trial name
- NCT06222684
- Testing
- Music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Nutritional Physiological Phenomena
Gene Polymorphism of Taste Receptors and Circulating Endocannabinoids in Normal Weight and Obese Subjects
The study aims at evaluating in normal weight and obese subjects those factors such as taste sensitivity and circulating endocannabinoids in influencing dietary choice and thereby lipid and energy metabolism in order to design…
- Trial name
- NCT02729584
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Breast Cancer
Effect of Tamoxifen on Breast Density in Premenopausal Women With Breast Cancer or High Risk for Breast Cancer
RATIONALE: High estrogen levels may be associated with dense breast tissue and an increased risk of developing breast cancer. Tamoxifen may be effective in reducing breast density by decreasing estrogen levels.
- Trial name
- NCT00086749
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Atopic Dermatitis
Safety, Tolerability, Pharmacokinetics and Efficacy of Twice Daily Application of Topical BioLexa in Adult Healthy Subjects and Patients With Mild to Moderate Atopic Dermatitis
This is a Phase 1, randomised, double-blind, vehicle controlled study to determine the safety, tolerability, PK and efficacy of twice daily application of topical BioLexa™ lotion, administered for 28 days in adult healthy…
- Trial name
- NCT04544943
- Testing
- BioLexa- Cohort 1, BioLexa- Cohort 2, Gentamicin
- Where
- Australia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hoth Therapeutics, Inc.
Necrotizing Soft Tissue Infection
Characteristics of Patients With Necrotizing Soft Tissue Infections
To study the demographic characteristic of patients with necrotizing soft tissue infections.
- Trial name
- NCT04801615
- Testing
- Surgery
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Chronic Hepatitis C
A Phase 1 Study to Evaluate the Pharmacokinetics of GS-5816 in Subjects With Normal Hepatic Function and Moderate or Severe Hepatic Impairment
This is a Phase 1 Open-Label, Parallel-Group, Single-Dose Study to evaluate the Pharmacokinetics of GS-5816 in subjects with normal hepatic function and moderate or severe hepatic impairment.
- Trial name
- NCT01817985
- Testing
- GS-5816
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Contact Dermatitis
Effect of Tetrix on Alleviation of Burning,Itching Associated With Lesions of Contact Dermatitis
To determine if Tetrix Cream, when applied to the skin lesions on patients with contact dermatitis, improves the symptoms of burning and itching.
- Trial name
- NCT00646867
- Testing
- Tetrix
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Coria Laboratories, Ltd.
Cholangiocarcinoma, Biliary Stricture
Diagnostic Accuracy of ERCP-guided Versus Cholangioscopy-guided Tissue Acquisition in Patients With Indeterminate Biliary Strictures Suspected to be Intrinsic .
Primary Objective: To assess the diagnostic accuracy of cholangioscopy-based assessment using SpyDS technology compared to cholangiography-based assessment using ERCP-guided biopsy and brushing in patients with indeterminate…
- Trial name
- Cholangioscopy (NCT03140007)
- Testing
- single operator cholangioscopy, ERCP guided brushing and biopsy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Obesity
Diet Induced Weight Loss to Reduce Inflammation in Obese Women
Breast cancer is one of the most frequently seen cancers in the United States. It occurs at all ages but is particularly common in post menopausal women.
- Trial name
- NCT01699906
- Testing
- Diet regimen to induce weight loss
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Aging
Epigenetics in the Aging Process
This study will examine the role of epigenetics (heritable changes in gene function that occur without a change in DNA sequence) in the aging process.
- Trial name
- NCT00242255
- Where
- 4 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Skin Laxity, Skin Aging
Cucurbita Pepo Flowers Extract to Promote Skin Health
The aim of this cosmetic clinical trial is to learn if an extract of Cucurbita pepo flower (CpLfe) works to enhance skin health and resilience in adult women with photo-damage.
- Conditions
- Skin Laxity, Skin Aging, Skin Wrinkling
- Trial name
- EACpLfe22S01 (NCT06674005)
- Testing
- Cucurbita pepo L. Flowers Extract
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ritamaria Di Lorenzo
Glaucoma, Open-Angle, Normal Tension Glaucoma
Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) leading to optic nerve head (ONH) damage and associated visual field defects.
- Conditions
- Glaucoma, Open-Angle, Normal Tension Glaucoma, Ocular Hypertension
- Trial name
- NCT03870230
- Testing
- Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Dynamic Vessel Analyzer (DVA), Pattern Electroretinography (pERG)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Adherence, Patient
Identification of Surrogate Blood and/or Urine Biomarker for Immulina TM (Trademark) in Normal Humans
This is a pilot study for identifying plasma and/or urine-derived adherence/surrogate biomarker candidates for verifying Immulina™ ingestion by human volunteers (collected before and after consumption of Immulina™, a natural…
- Trial name
- NCT05556967
- Testing
- Immulina
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
Skin Pigmentation
Process Validation in Dermatology: Assessing Methods for UV Exposure (Artificial Source vs. Sunlight) and Efficacy Evaluation of Anti-Tanning Agents
The rationale of this study is to establish a robust method for assessing sun protection product efficacy in preventing erythema and tanning.
- Trial name
- NCT06384092
- Testing
- Test Sun Protection Cream, Benchmark Sun Protection Cream
- Where
- India
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd