Clinical trials: Normal Body Weight
Overweight and Obesity, Type 2 Diabetes Mellitus
A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release
The objectives of this trial are to assess the effects of steviol glycoside alone or in combination with a glycemic carbohydrate on blood glucose and endocrine and gut hormone secretion vs.
- Trial name
- NCT05287906
- Testing
- Water, Glucose, Steviol Glycosides
- Where
- 3 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Healhty, Overweight or Obesity
Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BGM1812 Injection Following Single and Multiple Subcutaneous Administration in Normal to Overweight or Obese But Otherwise Healthy Men and Women
This is a Phase 1, single-center, double-blind, placebo-controlled, dose-escalation study. The study will evaluate the pharmacokinetics (PK), pharmacodynamic (PD), preliminary efficacy, safety and tolerability of BGM1812…
- Trial name
- NCT07224399
- Testing
- BGM1812
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
Emergencies, Anesthesia
Comparison of Three Pre-oxygenation Strategies
Study objective: Comparing the efficacy of three different preoxygenation strategies, i.e. non-rebreather face mask (NRM), bag-valve-mask (BVM) with and BVM without additional positive end-expiratory pressure (PEEP) in three…
- Trial name
- NCT06370689
- Testing
- Preoxygenation
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Overweight
The Use of Diffuse Optical Spectroscopy to Characterize in Response to Weight-Loss Intervention
The first step in any clinical intervention against obesity involves sustained lifestyle changes. Researcher can use these strategies to beneficial the effects of weight and on cardiovascular risk.
- Trial name
- NCT02146885
- Testing
- Weight Control
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Congestive Heart Failure, Renal Impairment
A Study to Learn How the Study Treatment BAY1753011 Moves Into, Through and Out of the Body, How it Works, How Safe it is, and How it Affects the Body When Given Once as Tablet in Male and Female Participants With Reduced Kidney Function Compared to Matched Participants With Normal Kidney Function
Researchers are looking for a better way to treat people with heart failure. Heart failure is a condition which occurs when the heart does not pump blood as well as it should leading to shortness of breath, tiredness, and ankle…
- Trial name
- NCT05599997
- Testing
- Pecavaptan (BAY1753011)
- Where
- 2 sites in Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Rheumatoid Arthritis, Healthy
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
This study has two phases. Phase 1 will examine the role of inflammatory mediators called cytokines on growth hormone levels in women with rheumatoid arthritis (RA).
- Trial name
- NCT00034060
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Breast Neoplasms
Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial
The purpose of the ALPHA Trial is to examine the physiologic changes that occur in a woman's body when she begins exercising that may be related to a change in her risk of getting breast cancer.
- Trial name
- NCT00522262
- Testing
- Aerobic exercise intervention
- Where
- 2 sites in Canada
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- AHS Cancer Control Alberta
Drug Safety
Pharmacokinetics of Ceftaroline in Normal and Obese Subjects
The purpose of this study is to characterize plasma and urinary concentrations of ceftaroline following intravenous administration of a single dose of ceftaroline 600 mg in healthy subjects who are normal weight, overweight, and…
- Trial name
- NCT01648127
- Testing
- Ceftaroline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Keith A. Rodvold
Food Oriented Behavior
Behavioral and Neurofunctional Correlates of Intentional Motor Behaviors Towards Edible Stimuli in Normal-weight Subjects
This study aims to investigate, through behavioural tests combined with advanced neurofunctional methods, the neural bases of intentional behaviours towards edible stimuli using explicit and implicit paradigms in normal-weight…
- Trial name
- NCT04203706
- Testing
- Neurofunctional imaging
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Aging, Obesity
Resistance Exercise Training in the Older Population With Obesity
Background: Aging leads to an alteration in the immune response, characterized by a chronic inflammatory state, and a progressive decrease in muscle quantity and quality, a situation that increases in women and in the presence of…
- Trial name
- RETOPO (NCT06367296)
- Testing
- Prolonged resistance exercise training
- Where
- 2 sites in Chile
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Overweight , Obesity
A Study of Zovaglutide (ZT002 Injection) in Participants With Impaired Kidney Function and Healthy Participants
This study is a single-dose, open-label, parallel design phase I clinical study to evaluate the PK characteristics and safety of single subcutaneous injection of ZT002 Injection in participants with different degrees of renal…
- Trial name
- NCT07443059
- Testing
- Zovaglutide
- Where
- 3 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
Obesity, Abdominal
Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue
A fully functional brown fat helps maintain a healthy weight and decreases the risk of metabolic diseases such as type II diabetes (T2DM).
- Trial name
- BATNAD (NCT06627868)
- Testing
- NAD+ precursor
- Where
- Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Turku
Overweight
Shake It Up: Lipidomics of Lipoproteins and Diet
The purpose of this research is to understand how dietary fat is related to cardiovascular disease (CVD). This study tests the effect of different dietary fats on the level of fat in the blood and the particles that transport fat…
- Trial name
- NCT04120220
- Testing
- Heavy Cream, Soybean Oil
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Insulin Sensitivity, Obesity
The Effect of Brown Adipose Tissue Activation on Insulin Sensitivity in Humans
Recent findings document the presence of active brown adipose tissue (BAT) in humans. Cold exposure via adrenergic stimulation activates BAT, which combusts significant amounts of blood glucose and free fatty acid (FFA) to…
- Trial name
- NCT01791114
- Testing
- Cold exposure, Cold exposure plus propranolol, Thermoneutral Conditions
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Obesity
Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity
The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific…
- Trial name
- NCT07031297
- Testing
- Meal Study
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nitrogen Balance
The Effect of Irregular Meal Pattern on Nitrogen Balance in Healthy Normal-weight Women
Nitrogen balance (NB) is defined as the net difference between the intake of nitrogen (input) and its excretion (output). NB was considered as an indicator of the catabolic stress level.
- Trial name
- NCT05226650
- Testing
- Regular meal pattern, Irregular meal pattern
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Normal Body Weight, Obesity
Endocrine and Neural Control of Eating in Women
The purpose of this study is to better understand how female sex hormones influence the food intake in the gut system through the release of satiety hormones as well as through central regulative mechanisms in the brain that…
- Trial name
- NCT02994420
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obese
Monounsaturated Fatty Acids and Brown/Beige Adipose Tissue in Humans
Considering the high prevalence of obesity its comorbidities in Brazil and in the world, different therapeutic measures have been suggested.
- Trial name
- NCT03024359
- Testing
- Extra virgin olive oil
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Type 2 Diabetes, Obesity
Enhancement of Brown Adipose Tissue Function Via Chronic Pharmacological Treatment
Obesity is epidemic in Australia, and current preventative strategies have had limited success in alleviating this health crisis.
- Conditions
- Type 2 Diabetes, Obesity, Cardiovascular Disease
- Trial name
- NCT02236962
- Testing
- Ephedrine, pioglitazone
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Insulin Resistance, NAFLD
Reversal of Lipid-Induced Insulin Resistance
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have…
- Trial name
- NCT02193295
- Testing
- Caloric Restriction
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Yale University