Clinical trials: Normal Cognition
Lewy Body Disease, Dementia
MIBG in Aging and Neurologic Disorders
The purpose of the study is to investigate the use of a special radioactive drug called 123I-MIBG and myocardial MIBG scintigraphy.
- Conditions
- Lewy Body Disease, Dementia, Parkinsonism, Mild Cognitive Impairment
- Trial name
- NCT05514106
- Testing
- meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Medulloblastoma, Childhood, Cognitive Impairment
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
The efficacy of treatment with metformin for promoting cognitive recovery and brain growth in children/adolescents treated for a brain tumour will be investigated in a multi-site Phase III randomized double-blind…
- Trial name
- Met Med Can (NCT05230758)
- Testing
- Metformin hydrochloride (HCl) 500mg tablet
- Where
- 20 sites in Australia, Canada
- Volunteers
- 140 people
- Sponsor
- Donald Mabbott
Breast Cancer
Exercise and Cognitive (Brain) Function in Breast Cancer Patients Getting Chemotherapy After Breast Surgery
This study will primarily identify longitudinal associations between cardiorespiratory fitness (CRF) and cognitive function pre- (baseline) to post-chemotherapy (~3 months). This will be a prospective study of 50 BCS.
- Trial name
- NCT04616300
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Toronto
Breast Cancer
Exercise, Cancer and Cognition: The ECCO-Study
The "ECCO"-study evaluates the efficacy of simultaneous controlled exercise during neo/-adjuvant chemotherapy in breast cancer patients and its effects on neurocognition.
- Trial name
- ECCO (NCT04789187)
- Testing
- High-Intensity-Interval-Training, General Physical Activity Recommendations
- Where
- Austria
- Volunteers
- 126 people
- Sponsor
- Johannes Kepler University of Linz
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Breast Cancer, Cognitive Dysfunction
Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation
This study will test the preliminary efficacy of transcranial direct current stimulation (tDCS) to improve fatigue and cognition in women with a history of breast cancer and persistent fatigue.
- Conditions
- Breast Cancer, Cognitive Dysfunction, Fatigue
- Trial name
- NCT03143894
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Breast Cancer, Cognitive Impairment
Cognitive Training and Brain Stimulation in Women With Post-chemotherapy Cognitive Impairment
The aim of this study is to investigate whether a high definition tDCS-accompanied intensive cognitive training of working memory leads to performance improvement in women with post-chemotherapy cognitive impairment after breast…
- Trial name
- NeuroMod-PCCI (NCT04817566)
- Testing
- Anodal tDCS, Intensive cognitive training
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- University Medicine Greifswald
Rheumatoid Arthritis, Pain
Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients
The purpose of this study is to investigate how RA affect the brain structures in RA-patients and if anti-inflammatory treatment that target TNF-α or JAK OR physical training of hands has positive impact on neuropsychiatric…
- Conditions
- Rheumatoid Arthritis, Pain, Fatigue, Cognitive Decline
- Trial name
- NeuMRA (NCT04378621)
- Testing
- TNF-α inhibitor OR JAK inhibitor, Hand training
- Where
- Sweden
- Volunteers
- 212 people
- Sponsor
- Vastra Gotaland Region
Walking, Cognitive Function
Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia
The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia…
- Trial name
- NCT00494689
- Where
- 2 sites in Singapore
- Volunteers
- 30 people
- Sponsor
- Devathasan Neurology Practice Pte Ltd
Breast Carcinoma, Cancer Survivor
Memory and Thinking Skills Workshop to Improve Cognition in Gynecologic and Breast Cancer Survivors With Cognitive Symptoms
The purpose of this study is to examine thinking abilities, mood, and quality of life in cancer survivors before and after an 8-week group-based memory and thinking skills workshop.
- Conditions
- Breast Carcinoma, Cancer Survivor, Cognitive Side Effects of Cancer Therapy, Malignant Female Reproductive System Neoplasm
- Trial name
- NCT01641068
- Testing
- Cognitive Intervention, Educational Intervention, Functional Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Washington
Atherosclerosis, Cognitive Decline
Advancing Postmenopausal Preventive Therapy
Advancing Postmenopausal Preventive Therapy (APPT) is a randomized, double-blinded, placebo-controlled trial designed to determine the effects of tissue selective estrogen complex (TSEC) therapy on the progression of subclinical…
- Trial name
- APPT (NCT04103476)
- Testing
- Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Breast Cancer, Colon Cancer
Cognitive Processing Slowness as a Marker of Cognitive Impairment in Non-central Nervous System Cancer Patients
Cancer is a frequent disease considering that one person out of three will be confronted with it in their lifetime. Cancer patients often express complaints related to cognitive impairment as an outcome of their oncological…
- Conditions
- Breast Cancer, Colon Cancer, Cognitive Impairment
- Trial name
- RIVAGE (NCT05754060)
- Testing
- Saint-Louis Lille Battery (SSLIB)
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Systemic Sclerosis, Systemic Lupus Erythematosus
Clinical Risk Assessment of Cognitive Function in Systemic Autoimmune Diseases
Objectives: Systemic autoimmune diseases are chronic diseases characterized by chronic inflammation, vasculopathy, and autoimmune phenomena. Several organ involvements are typical, including the central nervous system.
- Conditions
- Systemic Sclerosis, Systemic Lupus Erythematosus, Myopathies, Inflammatory, Rheumatoid Arthritis
- Trial name
- NCT06029335
- Where
- Hungary
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Breast Cancer
Study of the Effects of Chemotherapy on Memory and Other Mental Functions in Women With Breast Cancer
Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog.
- Trial name
- NCT00260975
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Autism Spectrum Disorder
Transcranial Magnetic Stimulation (rTMS) and Autism.
In this protocol we aim to use rTMS to better characterize STS role in normal and abnormal social cognition. With that purpose, we will measure the effect of inhibitory and excitatory rTMS on the fixation time on social scenes…
- Trial name
- TMSAUTISME (NCT01648868)
- Testing
- Transcranial Magnetic Stimulation (rTMS)
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
EEG Brain Oscillations, Alzheimer's Disease (AD)
Effects of Endogenous Gamma Light Stimulation on Brain Oscillations in Cognitively-normal Older Adults
This study aims to evaluate the effects of endogenous gamma non-flickering light stimulation on resting-state EEG rhythms and cognitive function in cognitively healthy older adults.
- Conditions
- EEG Brain Oscillations, Alzheimer's Disease (AD), Cognitively Normal Older Adults
- Trial name
- NCT06715995
- Testing
- Gamma Wave Stimulation Table Lamp (Aleddra, Inc., USA)
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cognition, Aging
Cognition in the Study of Tamoxifen and Raloxifene
The purpose of this study is to assess the effects of tamoxifen and raloxifene on cognitive aging in selected cognitively-healthy women.
- Trial name
- Co-STAR (NCT00687102)
- Testing
- tamoxifen, raloxifene
- Where
- 134 sites in United States, Canada
- Volunteers
- 1,498 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
System; Lupus Erythematosus, Cognition Disorder
Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune and inflammatory disease. The pathogenesis of SLE results from interactions between genes, hormones, and the environment; however, the exact etiology is unknown.
- Conditions
- System; Lupus Erythematosus, Cognition Disorder, Autoimmune
- Trial name
- NCT05984316
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Biruni University
Brain Cancer, Brain Tumor
HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Service Members, Veterans and civilians who are survivors of brain cancer…
- Conditions
- Brain Cancer, Brain Tumor, Brain Neoplasms, Primary Brain Tumor
- Trial name
- HOBSCOTCH-CA (NCT06930846)
- Testing
- HOBSCOTCH-CA
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia
Clinical Trial of Tolcapone for Cognition in Schizophrenia
This study will evaluate whether Tolcapone improves cognition in healthy volunteers as well as patients with schizophrenia. Talcapone is a drug that has been FDA approved for Attention Deficit Disorder and allegedly increase the…
- Trial name
- NCT00044083
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)