Clinical trials: Normal Control, open to volunteers
Healthy Subjects, Cold Urticaria
A Phase 1 Study of GTX-B001 in Healthy Subjects and Patients With Chronic Inducible Urticaria
This is a first-in-human study aimed at determining the safety of a single dose of GTX-B001 in healthy participants and in people with chronic inducible urticaria.
- Conditions
- Healthy Subjects, Cold Urticaria, Symptomatic Dermographism, Chronic Inducible Urticaria
- Trial name
- CHILL-MC (NCT07181369)
- Testing
- GTX-B001, Normal Saline
- Where
- 5 sites in Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Granular Therapeutics Limited
Alveolar Ridge Preservation, Tooth Loss
Volumetric Efficacy of Alveolar Ridge Preservation
The goal of this clinical trial is to compare the effectiveness of four post-extraction socket management approaches in preserving alveolar ridge dimensions following tooth extraction in adults requiring implant-supported…
- Conditions
- Alveolar Ridge Preservation, Tooth Loss, Tooth Extraction, Tooth Extraction Site Healing
- Trial name
- ARP (NCT07812883)
- Testing
- Spontaneous Healing, d-PTFE Membrane, Leukocyte- and Platelet-Rich Fibrin (L-PRF)
- Where
- Chile
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidad del Desarrollo
Atopic Dermatitis, Atopic Dermatitis Eczema
A Study to Evaluate the Efficacy and Safety of IMG-007 in Adult Participants With Moderate-to-Severe Atopic Dermatitis
The purpose of this study is to evaluate the efficacy and safety of different dose regimens of IMG-007, compared to placebo.
- Conditions
- Atopic Dermatitis, Atopic Dermatitis Eczema, Eczema
- Trial name
- ADAPTIVE (NCT07037901)
- Testing
- IMG-007
- Where
- 30 sites in United States, Australia and 2 more
- Volunteers
- 405 people
- Sponsor
- Inmagene LLC
Scar
Tissue-engineered Skin Graft Repair of Autologous Scar Dermal Scaffolds
Hypertrophic scar is an inevitable outcome of wound repair. It affects the appearance and some scar contracture often leads to joint dysfunction.Patients have low quality of life, long treatment cycle, heavy social burden and…
- Trial name
- NCT04389164
- Testing
- Tissue-engineered skin grafts of autologous scar dermal scaffolds
- Where
- China
- Volunteers
- 226 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Breast Cancer Female, Endocrine Therapy
The Benefits of Continued Use of Ovarian Function Suppression After 5 Years
To observe and evaluate the clinical efficacy and safety of continuous use of OFS for premenopausal patients with early breast cancer after 5 years use of OFS.
- Trial name
- NCT06050109
- Testing
- OFS continues to use group after 5 years use, Immunohistochemical detection of HR status
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Hongmei Zheng, PhD
Gingival Recession, Generalized, Gingival Recession, Localized
Clinical and Histological Evaluation of Subepithelial Connective Tissue Graft Maturation at Different Healing Timepoints, With and Without Topical Application of a Polynucleotide- and Hyaluronic Acid-Based Gel
This study evaluates whether a 9-week healing interval is sufficient for subepithelial connective tissue graft (SCTG) maturation after palatal harvesting, and whether topical application of a polynucleotide and hyaluronic acid…
- Conditions
- Gingival Recession, Generalized, Gingival Recession, Localized, Wound Healing, Palate; Wound
- Trial name
- NCT07708051
- Testing
- polynucleotide and hyaluronic acid gel, subepithelial connective tissue graft harvesting
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Atopic Dermatitis
A Study of BBT001 in Healthy Volunteers (HVs) and in Adult Patients With Atopic Dermatitis (AD)
This is a Phase 1, randomized, blinded, placebo controlled, single-ascending dose (SAD) and multiple-ascending dose (MAD) study of BBT001 in healthy volunteers (HVs) and adult patients with moderate to severe Atopic Dermatitis…
- Trial name
- NCT06808477
- Testing
- BBT001
- Where
- 14 sites in United States, Australia and 2 more
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Bambusa Therapeutics
Warts
Hyperthermia Combined With Hydrogen Peroxide Microneedle Patch for Viral Warts
Hyperthermia treatment (hyperthermia) refers to treating diseases with temperature (39-45 ° C) beyond normal body temperature,. It has been reported that local warming at 44 ° C is able to effectively mobilize the body's immunity…
- Trial name
- NCT07534865
- Testing
- 3% hydrogen peroxide solution, 0.9 % saline, Hyperthermia at 44℃
- Where
- China
- Volunteers
- 210 people
- Sponsor
- First Hospital of China Medical University
Hot Flashes, Breast Cancer
Acupuncture for Hot Flashes in Patients With Hormone Receptor-positive Breast Cancer.
This study intends to further evaluate the efficacy of acupuncture by comparing the intervention effects of different acupuncture treatment regimens on hot flashes in breast cancer ; and to explore the central effect regulation…
- Conditions
- Hot Flashes, Breast Cancer, Acupuncture
- Trial name
- NCT05460819
- Testing
- Acupuncture treatment
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
ICSI, IVF
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders
To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.
- Conditions
- ICSI, IVF, Normal Responders, Infertility Assisted Reproductive Technology
- Trial name
- DT-HCG-IVF (NCT07861399)
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), hCG trigger
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Sjogren Syndrome, Healthy Volunteers
"Core Stabilization Strenght and Pelvic Floor Functions in Primary Sjogren's"
This study aims to explain the comparison of core stabilization strength and pelvic floor functions between individuals diagnosed with Sjogren syndrome and a healthy control group. (Sjogren syndrome group n=27; control group n=27)
- Trial name
- NCT06879444
- Testing
- Core Muscle testing and patient reported outcome measures
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Atopic Dermatitis
A Phase 2b Dose-Ranging Study to Evaluate the Efficacy and Safety of ENV-294 in Adults With Moderate-to-Severe Atopic Dermatitis
This double-blind, placebo-controlled study is designed to evaluate the safety and efficacy of ENV-294 in adults with moderate-to-severe atopic dermatitis (AD).
- Trial name
- NCT07643766
- Testing
- ENV-294
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Enveda Therapeutics
Lymphedema, Lower Limb, Extracorporeal Shock Wave Therapy
Extracorporeal Shock Wave Therapy in Lower Extremity Lymphedema
Lower extremity lymphedema is a chronic and progressive condition associated with significant functional impairment and reduced quality of life.
- Conditions
- Lymphedema, Lower Limb, Extracorporeal Shock Wave Therapy, Edema Leg, Sham-controlled
- Trial name
- NCT07626645
- Testing
- Extracorporeal Shock Wave Therapy (ESWT)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gazi University
Intentional Correction of Forehead Wrinkles (crow's Feet)
A Prospective, Multicenter, Blind, Randomized Controlled, Optimal Clinical Trial to Evaluate the Safety and Efficacy of Medical Collagen Fillers for Facial Dermal Tissue Filling to Correct Frontal Wrinkles (crow's Feet)
With the development of medical technology and the improvement of life treatment, people's concept of aging is also changing, people of all ages are constantly pursuing a young and healthy life, the use of lasers and fillers to…
- Trial name
- NCT06703294
- Testing
- Crow's feet injection filling, Humanized collagen filling crow's feet
- Volunteers
- 260 people
- Sponsor
- Fiman (Changchun) Pharmaceutical Biotechnology Company Limited
Mucosal Erosion, Gingival Recession
Patient-reported Outcomes of Donor Site Healing Using Different Palatal Protection Techniques
This study has been initiated to evaluate the question, "What is the best way to protect the palate after a gum graft is removed?" The overall objective is to determine if there is a difference in PROMs of donor site healing…
- Trial name
- NCT06892496
- Testing
- Visual Analog scale (VAS) questionnaire, Vacuum-formed retainer (VFR) technique, 3-D printed acrylic resin stent (3DS) technique
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Virginia Commonwealth University
Ankle Disease, Foot Diseases
Dexamethasone vs Dexmedetomidine vs Combination as Adjuvants to Popliteal Sciatic Nerve Block in Children
This clinical study will evaluate three commonly used medications that can be added to local anesthetic during a popliteal sciatic nerve block in children undergoing surgery of the lower leg or foot.
- Trial name
- NCT07289620
- Testing
- Dexamethasone, Dexmedetomidine, Dexamethasone + Dexmedetomidine
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Medical Sciences
Lymphedema, Breast Cancer
Gentle Touch for Post-Mastectomy Lymphedema
This is a single-blind, parallel-group Randomized Controlled Trial (RCT) comparing the efficacy of a specialized manual technique, Gentle Touch (GT), versus a control intervention, both added to the usual rehabilitative care.
- Trial name
- GT-BCRL (NCT07257679)
- Testing
- Gentle Touch (GT) Lymphatic Drainage (ANDOS technique), Passive Mobilization and Active-Assisted Exercises for the Upper Limb
- Where
- 2 sites in Italy
- Volunteers
- 36 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Dermatochalasis of Upper Eyelid, Blepharoplasty
Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes
The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related…
- Trial name
- P4LE (NCT07734740)
- Testing
- Sodium Bicarbonate (NaHCO3), Warmed lignocaine, Hyaluronidase Injection
- Where
- 3 sites in Hong Kong
- Volunteers
- 80 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Vitiligo, Non-Segmental Vitiligo (NSV)
Study of D-2570 in Subjects With Non-Segmental Vitiligo
This study tests D-2570, an investigational drug, in people with non-segmental vitiligo to check its safety and effect on skin discoloration.
- Trial name
- D2570-206 (NCT07625891)
- Testing
- D-2570 Dose 1, D-2570 Dose 2, D-2570 Dose 3
- Where
- China
- Volunteers
- 160 people
- Sponsor
- InventisBio Co., Ltd
Wound, Foot, Diabetic Foot Ulcer (DFU)
CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs
CAMPR-II Trial: A multicenter hybrid platform trial comparing the effects of a prospective cohort treated with a saline-hydrated allogeneic dual-layer amniotic membrane product or a synthetic, resorbable polymeric wound matrix to…
- Conditions
- Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
- Trial name
- CAMPR-II (NCT07701590)
- Testing
- Microlyte®, IP 1: Membrane Wrap - Hydro
- Where
- 7 sites in United States
- Volunteers
- 147 people
- Sponsor
- Capsicure, LLC