Clinical trials: Normal Drug Tolerance
Healthy, Lung Disease
Effects of Endotoxin in Normal Human Volunteers
Bacterial infections can progress to a life-threatening illness called septic shock, characterized by low blood pressure and vital organ damage.
- Conditions
- Healthy, Lung Disease, Sepsis, Septic Shock
- Trial name
- NCT00001303
- Testing
- Reference Endotoxin, Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pediatric Obesity, Insulin Resistance
Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance
The primary objective of this randomized, parallel group, double-blind, placebo-controlled study is to determine whether treatment with metformin enhances insulin sensitivity in a group of ethnically diverse obese…
- Conditions
- Pediatric Obesity, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT00667498
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Systemic Lupus Erythematosus
Autologous Stem Cell Transplantation for Refractory Systemic Lupus Erythematosus (ASSIST)
While glucocorticoids and immunosuppressants ameliorate manifestations of SLE in many patients, current therapies are insufficient to control the disease in a subset of patients, and their clinical prognosis remains poor due to…
- Trial name
- ASSIST (NCT00750971)
- Testing
- Immunoablation and Autologous Hematopoietic Stem Cell Transplantation
- Where
- 8 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Eczema, Dermatitis
Black Tea Compresses for Facial Eczema and Perioral Dermatitis
Facial eczema and perioral dermatitis are clinical entities that develop exclusively in the face and present a special therapeutic challenge.
- Trial name
- NCT02941432
- Testing
- Black tea compress treatment
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- University of Luebeck
Post-inflammatory Hyperpigmentation
Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Post-inflamamatory Hyperpigmentation (PIH).
CS5_2 study aims to evaluate the tolerance of 4 different conditions of cryotherapy treatments applied on dorsal post-inflammatory hyperpigmentation (PIH) spots.
- Trial name
- NCT05495503
- Testing
- Prototype (814A-v1), Prototype (814B-v1), Prototype (814C-v1)
- Where
- South Africa
- Volunteers
- 12 people
- Sponsor
- Cryonove Pharma
Herpes Simplex, HIV Infections
The Safety and Effectiveness of Valacyclovir HCl in the Treatment of Herpes Simplex or Varicella/Zoster Infections in HIV-1 Infected Children
To obtain tolerance, safety, and pharmacokinetic data for oral valacyclovir hydrochloride ( 256U87 ) in HIV-1 infected children with herpes simplex virus infections ( cold sores ) and/or varicella / zoster virus infections …
- Conditions
- Herpes Simplex, HIV Infections, Chickenpox
- Trial name
- NCT00001054
- Testing
- Valacyclovir hydrochloride
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetic Macular Edema
Intra-individual Variability and Circadian Rhythm of VEGF Levels and Interaction With Biomarkers
The study evaluates the intra-individual variability of VEGF levels over a period of 6 months as well as the circadian variation of VEGF levels, both under standardized conditions in patients with type 2 diabetes without DME and…
- Trial name
- NCT02325271
- Testing
- Frequent blood and urine sampling and blood pressure measurement
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GWT-TUD GmbH
Recurrent Glioblastoma, CD147 Positive
CD147-CART Cells in Patients With Recurrent Malignant Glioma.
This is a single-center, single-arm, open label and dose escalation clinical study of anti-CD147 CART cells in patients with recurrent malignant glioma.
- Trial name
- NCT04045847
- Testing
- CD147-CART
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Xijing Hospital
Vasculitis, Wegener's Granulomatosis
Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis
Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is the most common type of small blood vessel inflammation in adults.
- Conditions
- Vasculitis, Wegener's Granulomatosis, Microscopic Polyangiitis
- Trial name
- RAVE (NCT00104299)
- Testing
- Azathioprine, Methylprednisolone (or other glucocorticoid), Prednisone
- Where
- 8 sites in United States, Netherlands
- Volunteers
- 197 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Atopic Dermatitis / Eczema
To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin
The investigation will evaluate, under dermatological control, the cutaneous in-use tolerance of E45 Eczema Repair Emollient with two or three times daily application, over a period of two weeks on children and babies with…
- Trial name
- NCT02857062
- Testing
- E45 Eczema Repair Emollient
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Immune Thrombocytopenia (ITP), Systemic Lupus Erythematosus (SLE)
Autoreactivity Threshold Analysis in Lupus and Immune Thrombocytopenia (Checkpoints ITP and SLE)
The aim of this proposal is to test if anti-BAFF antibody can restore a normal threshold of tolerance in patients in two auto-immune diseases along the RITUX-PLUS study in immune thrombocytopenia, and along the Believe study in…
- Trial name
- ITP&SLE (NCT03975361)
- Testing
- Bliss-Believe
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Advanced Cancer, Brain Involvement
Study of 4-Demethylcholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in Patients With Advanced Cancer
DM-CHOC-PEN is a polychlorinated pyridine cholesteryl carbonate that has demonstrated antineoplastic activities in human xenograft intracerebrally implanted tumor mouse models, acceptable preclinical toxicities in mouse, rat and…
- Trial name
- DM-CHOC-PEN (NCT01048008)
- Testing
- DM-CHOC-PEN
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- DEKK-TEC, Inc.
Pruritus
Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study
Chronic pruritus affects 10-20% of the population and causes a major reduction in quality of life, comparable to pain, with significant psychological, social, and functional consequences.
- Trial name
- CANNA-ITCH (NCT06435299)
- Testing
- Cannabis oil
- Where
- 6 sites in France
- Volunteers
- 218 people
- Sponsor
- University Hospital, Brest
Rheumatoid Arthritis
Exposure Study Comparing 3 Routes of Methotrexate (MTX) Administration
Pharmacokinetics (PK) study
- Trial name
- NCT01737944
- Testing
- Methotrexate (MTX)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Antares Pharma Inc.
Obesity
Evaluation of the Effect of Moderate-intensity Physical Activity on Glycemic Variability
Obesity is a major public health problem on the world and Mexico too, in addition the obesity develops chronic non-communicable diseases (NCD) such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD).
- Trial name
- NCT02620670
- Testing
- Physical activity of moderate intensity for 3 days
- Where
- Mexico
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Healthy
A 24 Hour Occlusive Single Patch Test to Assess Acute Tolerance of Pre Lubricated Condom on a Panel of Healthy Adult Subjects
This is a 24 hour patch test to determine the acute tolerance of 3 variants of condom on a panel of healthy adult subjects. The patches will be affixed to the back and remain under occlusion for 24 hours.
- Trial name
- NCT02864966
- Testing
- Condom
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Food Allergy in Infants, Proctocolitis
Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive...
- Conditions
- Food Allergy in Infants, Proctocolitis, Atopic Dermatitis, Reflux, Gastroesophageal
- Trial name
- NCT04651829
- Testing
- oral food challenge 1, oral food challenge 2
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Armand Trousseau
Skin Diseases, Infectious, Skin Diseases, Bacterial
Phase 2 Study of TR-701 in Patients With Complicated Skin and Skin Structure Infections
The purpose of the study is to determine the oral dosage of TR-701 to be used in Phase III studies in patients with complicated skin and skin structure infections.
- Trial name
- NCT00761215
- Testing
- TR-701 200 mg, TR-701 300 mg, TR-701 400 mg
- Where
- 12 sites in United States
- Volunteers
- 192 people
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Fine Lines, Wrinkles
A Clinical Study Evaluating the Efficacy and Tolerability of a Topical Facial Treatment For Facial Rejuvenation
This single-center clinical trial was conducted to evaluate the efficacy and tolerability of a topical facial treatment when applied by a license esthetician in clinic in a series of 3 sessions with 1 month intervals, in…
- Conditions
- Fine Lines, Wrinkles, Laxity; Skin
- Trial name
- NCT06629792
- Testing
- Gentle Cleanser, Facial Moisturizer, sunscreen SPF 30
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Atopic Dermatitis
Tolerance and Efficacy Open-label Study With RV4421B, in Various Populations With Atopic Dermatitis for 12 Weeks
Pierre Fabre Laboratories have developed a cream with medical device status, RV4421B-EV0407 indicated for the treatment of eczemas, including atopic eczema, contact eczema and chronic hand eczema.
- Trial name
- NCT07014007
- Testing
- RV4421B- EV0407
- Where
- Mauritius
- Volunteers
- 105 people
- Sponsor
- Pierre Fabre Dermo Cosmetique