Clinical trials: Normal Drug Tolerance
Solid Tumor, Adult, Triple Negative Breast Cancer
AVID100 in Advanced Epithelial Carcinomas
Approximately 90 male and female patients with documented solid tumor malignancies of epithelial origin that are locally advanced or metastatic, and either refractory to standard therapy or for whom no standard therapy is…
- Conditions
- Solid Tumor, Adult, Triple Negative Breast Cancer, Head and Neck Squamous Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT03094169
- Testing
- AVID100 IV
- Where
- 10 sites in United States
- Volunteers
- 49 people
- Sponsor
- Formation Biologics
Seroma
Safety of the Use of Compressive Taping in Seroma
Seroma is the most common complication at the beginning of healing after surgery for breast cancer treatment. Its incidence varies in the literature from 2.5 to 90% and is defined as a collection of serous fluid that develops…
- Trial name
- NCT03590704
- Testing
- Vitaltape® bandage
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Breast Cancer
The Trial Comparing Dose-dense AC-T With PC as Adjuvant Therapy for TNBC
The purpose of this trial is to compare the 3 years DFS of dose-dense epirubicin and cyclophosphamide followed by paclitaxel with paclitaxel plus carboplatin as adjuvant therapy for triple-negative breast cancer.
- Trial name
- NCT01378533
- Testing
- epirubicin, cyclophosphamide, paclitaxel, carboplatin, G-CSF
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Medical Sciences
Glucose Intolerance, Hyperinsulinemia
Health Effects of Liposuction in Overweight Women With Elevated Insulin Levels, Impaired Glucose Tolerance and/or Type 2 Diabetes
This study is for women who have already decided to undergo liposuction at Georgetown University Medical Center in Washington, D.C.
- Conditions
- Glucose Intolerance, Hyperinsulinemia, Diabetes Mellitus, Non Insulin Dependent, Obesity
- Trial name
- NCT00005760
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Breast Cancer
Safety and Tolerability of Recombinant Humanized Anti-PD-1 Monoclonal Antibody for Patients With Advanced Breast Cancer
This is a mono-center, open-label, phase 1 study evaluating the humanized anti-PD-1 antibody JS001, as a monotherapy in patients with triple negative breast cancer who have failed in routine systemic treatment.
- Trial name
- NCT02838823
- Testing
- humanized anti-PD-1 monoclonal antibody toripalimab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Atopic Dermatitis
Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children
Atopic dermatitis (AD) is an immune disorder, characterized by chronic skin inflammation or relapsing, whose prevalence is increasing worldwide. Its exact etiology remains unknown.
- Trial name
- NCT02519556
- Testing
- Probiatop
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Casa Espirita Terra de Ismael
ER+, HER2- Advanced Breast Cancer, Metastatic Breast Cancer
Study of TFX06 in Women With Advanced Breast Cancer.
A Phase 1/2 Dose Escalation and Expansion Study of TFX06 tablet Alone in Women with ER Positive, HER2 Negative Advanced Breast Cancer
- Trial name
- NCT05927779
- Testing
- TFX06 tablet
- Where
- 2 sites in China
- Volunteers
- 74 people
- Sponsor
- Zhejiang Yangli Pharmaceutical Technology Co., Ltd.
Immune System Tolerance, Depression
ESAN II - Energy Sensing in Depression
The purpose of this study is to assess the effects of polyphenols from natural aronia juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Immune System Tolerance, Depression, Obesity, Microbial Colonization
- Trial name
- NCT05432362
- Testing
- Aronia Juice
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Endovascular Carotid Surgery, Preoperative Hypotension
Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery
The effects on brain perfusion of the two currently vasopressors used to treat accidental hypotension occurring during carotid surgery (i.e.
- Trial name
- VP-hTA-XCar (NCT01794273)
- Testing
- ephedrine and phenylephrine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Breast Cancer, Neoplasm Metastasis
Capecitabine Associated With Weekly Paclitaxel in Metastatic Breast Cancer.
Tolerance and efficacy of administration of capecitabine 5 out of 7 days associated with weekly paclitaxel compared to the recommended treatment plan of weekly paclitaxel - capecitabine, in patients with metastatic breast cancer.
- Trial name
- NCT00270491
- Testing
- Paclitaxel, Capecitabine
- Where
- France
- Volunteers
- 130 people
- Sponsor
- ARCAGY/ GINECO GROUP
Rheumatoid Arthritis
Oral Collagen for Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disease characterized by swelling and inflammation of the joints. In RA, the immune system attacks a person's own cells inside joints, eventually leading to joint damage and disability.
- Trial name
- NCT00000401
- Testing
- Oral bovine type II collagen
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Tennessee
Breast Cancer, Advanced HR+/HER2- Breast Cancer
Study of Sacituzumab Govitecan With Atropine to Improve Tolerability in Advanced TNBC and HR+/HER2- Breast Cancer
The SATROPIN study is an international, multicenter, open-label, single-arm, phase II clinical trial to assess whether the use of prophylactic administration of atropine may prevent diarrhea in participants with unresectable…
- Conditions
- Breast Cancer, Advanced HR+/HER2- Breast Cancer, Advanced Triple-Negative Breast Cancer
- Trial name
- SATROPIN (NCT07367178)
- Testing
- Sacituzumab Govitecan (SG), Atropine, G-CSF (Granulocyte colony-stimulating factor)
- Volunteers
- 30 people
- Sponsor
- MedSIR
Breast Cancer
Water-based Versus Land-based Exercise for Breast Cancer Survivors
Physical activity and exercise have demonstrated to be an integral part of the cancer-continuum care. Despite strong evidence suggesting that both endurance and strength training should be encourage in cancer patients, there is…
- Trial name
- NCT03730818
- Testing
- Water-based Exercise Group, Land-based Exercise Group
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universitat Pompeu Fabra
Alopecia Areata
Evaluating the Effectiveness and Tolerance of Baricitinib in the Treatment of Acute Alopecia Areata With Active Hair Shedding: A Prospective Open-Label Study
Alopecia areata (AA) in the acute phase with active hair shedding causes significant psychological distress, prompting the need for effective treatment.
- Trial name
- MQ7422 (NCT06797310)
- Testing
- Baricitinib
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Rheumatoid Arthritis (RA), Rheumatology
An Artificial Intelligence-powered Approach to Precision Immunotherapy of Human Arthritis
This clinical study is a multi-center, randomized, double-blind, placebo-controlled, outpatient study comparing the efficacy of combination of dnaJP1 peptide and hydroxychloroquine versus combination of placebo and…
- Trial name
- dnaJP1 (NCT07013110)
- Testing
- dnaJP1
- Where
- Singapore
- Volunteers
- 124 people
- Sponsor
- Prof Salvatore Albani
Breast Cancer
BENEFIT OF MECHANICAL ISCHEMIC PRECONDITIONING ON TOLERANCE OF ADIPOSE TISSUE TO ISCHEMIA REPERFUSION OF TYPE DIEP (DEEP INFERIOR EPIGASTRIC PERFORATOR) FREE FLAPS.
Breast cancer is the most common cancer amongst women in terms of frequency, with more than 50 000 newly diagnosed cases per year in France. The average 5-year survival rate for women with breast cancer is around 85%.
- Trial name
- PRIMIDIEP (NCT05373069)
- Testing
- Mechanical ischemic preconditioning of diep-type flap
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitiligo
Determining the Tolerance of Depigmented Skin to Targeted Phototherapy Using UVB in Patients With Vitiligo
The purpose of this study is to determine if vitiligo patients develop tolerance to ultraviolet light therapy, a type of treatment available for vitiligo.
- Trial name
- NCT00367224
- Testing
- 6 to 9 ultraviolet B treatments, Skin biopsies
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Atopic Dermatitis (AD)
EFFICACY AND TOLERANCE OF AN EMOLLIENT CREAM IN SKIN OF COLOR
The aim of this study is to evaluate the efficacy and tolerance of a face and body emollient cream in individuals (infants, children, adults) with phototypes IV-VI presenting mild to moderate atopic dermatitis (study under…
- Trial name
- NCT07839897
- Testing
- Emollient cream RV4660B
- Where
- Brazil
- Volunteers
- 59 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Solar Lentigo, Senile Lentigo
Performance and Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in th Treatment of Brown Spots (Solar and Senile Lentigines, Post-Inflammatory Hyperpigmentation) on the Face and Hands of Asian Ethnicity Skins
CS5_4 study aim to evaluate the performance and the tolerance of 3 prototypes of cyto-selective cryotherapy treatments applied on the brown spots on the face and hands of asian ethnicity skins (chinese).
- Trial name
- NCT05886010
- Testing
- prototypes 1 everyday, prototypes 1 every week, prototypes 1 every two weeks
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Cryonove Pharma
Early Stage Breast Carcinoma
Tolerance of PICC Line Versus Implanted Port for Adjuvant Chemotherapy in Early Breast Cancer
Adjuvant chemotherapy is frequently proposed to patients presenting early breast cancer, in case of high risk of recurrence (large tumors, node involvement, high grade…).
- Trial name
- EPIC (NCT02095743)
- Testing
- implanted port for chemo administration (X-port isp), Use of a PICC line for chemo administration (PowerPICC SOLO²)
- Where
- France
- Volunteers
- 256 people
- Sponsor
- Centre Henri Becquerel