Clinical trials: Normal Drug Tolerance
Brain Tumor, Virtual Reality
Brain Awake Surgery Using Virtual Reality Headset
Feasibility and tolerance study of virtual reality headset for brain mapping during brain awake surgery.
- Trial name
- CERVO1 (NCT03010943)
- Testing
- Virtual reality headset
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Angers
Pediculosis
Pharmacokinetic (PK) and Tolerance Study of Natroba Topical Suspension in Pediatrics With an Active Head Lice Infestation
A pharmacokinetic and tolerance study of Natroba (spinosad) Topical Suspension, 0.9% in pediatric subjects 6 months to 4 years of age with an active head lice infestation.
- Trial name
- NCT01660321
- Testing
- spinosad
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- ParaPRO LLC
Rheumatoid Arthritis, Ankylosing Spondylitis
Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases
TRANSREG will assess the safety and biological efficacy of low-dose IL2 as a Treg inducer in a set of 14 autoimmune and auto-inflammatory diseases, with the aim to select diseases in which further therapeutic development will be…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus, Psoriasis
- Trial name
- TRANSREG (NCT01988506)
- Testing
- Interleukin 2
- Where
- 11 sites in France
- Volunteers
- 81 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Neoplasms, Skin Neoplasms
Safety Study of Amphinex Based Photochemical Internalisation (PCI) of Bleomycin in Patients With Cutaneous Cancer
This study is an open, non- randomized, phase I, dose-escalating study to evaluate the safety and tolerance of Amphinex based PCI of bleomycin in patients with local recurrent or advanced/metastatic, cutaneous or sub-cutaneous…
- Trial name
- NCT00993512
- Testing
- Amphinex (TPCS2a), Bleomycin, Illumination with CeramOptec laser
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- PCI Biotech AS
Osteoarthritis, Rheumatoid Arthritis
Scorpio Non Restricted Geometry (NRG) Study in Japan
The purpose of this study is to evaluate the range of motion (ROM), mid-flexion stability (gap balance), and implant position (size and angle) for the Scorpio NRG device.
- Trial name
- NCT02552082
- Testing
- Scorpio NRG posterior stabilized (PS)
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Stryker Japan K.K.
Dental Health
Oral Tissue Tolerance of a Mouthrinse
This study is 8 weeks long. People participating in this study will be asked to brush their teeth two times a day. Some people will get a mouthwash. People with a mouthwash will rinse two times a day after brushing their teeth.
- Trial name
- NCT01009554
- Testing
- Potassium Oxylate Mouthwash, Sodium Fluoride Dentifrice
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Obesity
Evaluation of the Effect of Moderate-intensity Physical Activity on Glycemic Variability
Obesity is a major public health problem on the world and Mexico too, in addition the obesity develops chronic non-communicable diseases (NCD) such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD).
- Trial name
- NCT02620670
- Testing
- Physical activity of moderate intensity for 3 days
- Where
- Mexico
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Venous Leg Ulcer, Chronic Venous Insufficiency
Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs)
The purpose of the study is to assess treatment tolerance and comfort in chronic VLUs after 4 weeks of treatment using a dual action pneumatic compression device.
- Conditions
- Venous Leg Ulcer, Chronic Venous Insufficiency, Venous Stasis Ulcer, Venous Ulcer
- Trial name
- NCT02395302
- Testing
- Dual Action Pneumatic Compression
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Tactile Medical
No Disease State or Condition
Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
The purpose of this study is to determine if the topical application to gingival tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT03233737
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Insulin Resistance, Obesity
Surgical Removal of Visceral Fat Tissue (Omentectomy) Associated to Bariatric Surgery: Effects on Insulin Sensitivity
The intraabdominal fat is associated with insulin resistance, a condition that is in the basis of diabetes, metabolic syndrome and some cardiovascular diseases.
- Conditions
- Insulin Resistance, Obesity, Metabolic Syndrome X
- Trial name
- NCT00545805
- Testing
- Roux-en-Y Gastric Bypass plus total omentectomy, Roux-en-Y Gastric Bypass
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil
Safety Issues, Tolerance
Safety and Tolerability of 2 Dietary Supplement Beverages Designed to Maintain Healthy Blood Pressure.
This study is designed to evaluate the safety and tolerability of two distinct dietary supplement beverage formulations designed to maintain normal blood pressure.
- Trial name
- NCT06442293
- Testing
- Treatment 1, Treatment 2
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- USANA Health Sciences
Keloid
Safety of Juvista When Administered Following Excision of Ear Lobe Keloids
This trial will assess the safety and efficacy of 500ng Juvista per linear cm of wound margin administered by intradermal injection following the excision of keloid scars on the ear lobe.
- Trial name
- RN1001-0093 (NCT00710333)
- Testing
- Avotermin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Renovo
Lentigo Solar
Tolerance and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots
CS5_1 study aim to evaluate the tolerance and to adjust the mode of administration of 4 different conditions of cryotherapy treatments applied on the brown spots of the face and hand with 3 prototypes.
- Trial name
- NCT05600049
- Testing
- Prototypes (815-v1 001) to (815-v1 050), Prototype (815-v1 051) to (815-v1 100), Prototypes (815-v1 101) to (815-v1 150)
- Where
- Georgia
- Volunteers
- 33 people
- Sponsor
- Cryonove Pharma
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
Effects of Colesevelam HCl On Bile Acid Kinetics
This project will compare the amount of bile acids and their kinetics in overweight and obese people with normal glucose metabolism, impaired glucose tolerance and frank type 2 diabetes.
- Trial name
- NCT00476710
- Testing
- Colesevelam HCl
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- KineMed
Diarrhea, Atopic Dermatitis
Cesarean Section Study
Effect, tolerance and safety of a supplementation with a probiotic on the risk of gastrointestinal infections, on growth, and on gut microbiota in healthy newborn term infants born by Cesarean section.
- Trial name
- NCT01992497
- Testing
- Probiotic
- Where
- Germany
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Alopecia Areata
Evaluating the Effectiveness and Tolerance of Baricitinib in the Treatment of Acute Alopecia Areata With Active Hair Shedding: A Prospective Open-Label Study
Alopecia areata (AA) in the acute phase with active hair shedding causes significant psychological distress, prompting the need for effective treatment.
- Trial name
- MQ7422 (NCT06797310)
- Testing
- Baricitinib
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Advanced Cancer, Brain Involvement
Study of 4-Demethylcholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in Patients With Advanced Cancer
DM-CHOC-PEN is a polychlorinated pyridine cholesteryl carbonate that has demonstrated antineoplastic activities in human xenograft intracerebrally implanted tumor mouse models, acceptable preclinical toxicities in mouse, rat and…
- Trial name
- DM-CHOC-PEN (NCT01048008)
- Testing
- DM-CHOC-PEN
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- DEKK-TEC, Inc.
Ulcers, Leg
Assessment of Efficacy & Tolerance of Urgo 310 3166 Dressing in Local Venous or Mixed Leg Ulcers
Assessment of efficacy \& tolerance of Urgo 310 3166 dressing in the treatment of local venous or mixed leg ulcers.
- Trial name
- CASSIOPEE (NCT03126396)
- Testing
- Urgo 310 3166 dressing
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Laboratoires URGO
Heart Failure
Effects of Aliskiren on Patient With Heart Failure and a Normal Ejection Fraction
The primary objective of this study is to determine whether treatment with aliskiren (300 mg) compared to placebo will improve treadmill exercise time in older (age ≥ 55 years) patients with heart failure and normal ejection…
- Trial name
- Aliskiren (NCT00982033)
- Testing
- aliskiren
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Wake Forest University Health Sciences
TAKAYASU ARTERITIS
Efficacy and Tolerance of Tocilizumab In Takayasu Arteritis
First-line tocilizumab treatment during 6 months could permit rapid steroid-tapering and induction of remission in Takayasu arteritis (TA).
- Trial name
- TOCITAKA (NCT02101333)
- Testing
- Tocilizumab
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris