Clinical trials: Normal Drug Tolerance
Advanced Solid Tumor, Melanoma
Assessment of Safety ,Tolerance and Pharmacokinetics Clinical Efficacy With BAT4706 in Advanced Solid Tumors
A Phase I Clinical Study to Evaluate the Safety, Tolerance and Pharmacokinetics of BAT4706 Injection in Patients With Advanced Solid Tumors.
- Trial name
- NCT05148325
- Testing
- BAT4706
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Bio-Thera Solutions
Lentigo, Solar Lentigo
Evaluation of the Tolerance (Main Objective) and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) on the Face
The goal of this clinical trial is to compare the 3 different prototype of cyto-selective cryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities.
- Conditions
- Lentigo, Solar Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- CS5_10B (NCT06305897)
- Testing
- CRYONOVE (EC14_4osc), CRYONOVE (EC+05_1osc), CRYONOVE (EC+05_2osc)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Normal, Impaired Fasting Glucose
A Crossover Trial of Chitosan Oligosaccharide on Post Prandial Glucose Control in Subjects With Normal, IFG and IGT
It is well known that Chitosan oligosaccharide is low molecular weight and water soluble and chitosan oligosaccharide has been shown to reduce blood cholesterol and blood pressure, increase immunity, and enhance antitumor…
- Conditions
- Normal, Impaired Fasting Glucose, Impaired Glucose Tolerance
- Trial name
- NCT03650023
- Testing
- Chitosan Oligosaccharide (GO2KA1), White egg
- Where
- South Korea
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Glomerulonephritis, Lupus Nephritis
Cyclophosphamide and Fludarabine to Treat Lupus Nephritis
This study will test the safety and effectiveness of combination therapy with cyclophosphamide (Cytoxan) and fludarabine in treating lupus nephritis (kidney inflammation).
- Conditions
- Glomerulonephritis, Lupus Nephritis, Systemic Lupus Erythematosus
- Trial name
- NCT00001676
- Testing
- SQ Fludarabine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Old World Cutaneous Leishmaniasis
A Study to Evaluate the Efficacy and Tolerance of WR279,396 for Old World Cutaneous Leishmaniasis
This Phase 2 study is to determine whether WR279396 with occlusion (a polyurethane dressing) is more effective than WR279396 without occlusion for once daily treatment.
- Trial name
- NCT01536795
- Testing
- WR279,396 with Tegaderm Dressing, WR 279,396 with Gauze and Tape Dressing
- Where
- Tunisia
- Volunteers
- 48 people
- Sponsor
- U.S. Army Medical Research and Development Command
Severe Coronary Artery Disease, Obesity
Chronic Inflammatory Activation in Fat Tissue: An Atherogenic Factor in Severe Coronary Artery Disease
Chronic inflammatory activation in fat tissue can be the link between adiposity and an increased risk for atherosclerosis. The aim of this study is to investigate how molecular alterations in fat tissue can be influenced by…
- Conditions
- Severe Coronary Artery Disease, Obesity, Impaired Glucose Tolerance
- Trial name
- KFO (NCT00510705)
- Testing
- exercise training, exercise training + metformin, exercise training + glitazone
- Where
- Germany
- Volunteers
- 29 people
- Sponsor
- University of Leipzig
Mucopolysaccharidosis I
Immune Tolerance Study With Aldurazyme® (Laronidase)
The purpose of this study is to see if treatment with an antigen-specific immunosuppressive can decrease or stop an antibody response to laronidase (Aldurazyme®) during enzyme replacement therapy with laronidase in severe…
- Trial name
- NCT00741338
- Testing
- Laronidase, Cyclosporine A (CsA), Azathioprine (Aza)
- Where
- 2 sites in Brazil, Russia
- Volunteers
- 7 people
- Sponsor
- Genzyme, a Sanofi Company
Melanoma
A Study of HX008 Plus LP002 for the Treatment of Patients With Advanced Melanoma
The subsequent treatment choices for the patients with advanced melanoma, who have failed the immune checkpoint inhibitor therapy of single agent. Evidences showed that PD-1 and PD-L1 signalling pathways are not redundant.
- Trial name
- NCT04756934
- Testing
- HX008, LP002
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Taizhou HoudeAoke Biomedical Co., Ltd.
Eczema, Dermatitis
Black Tea Compresses for Facial Eczema and Perioral Dermatitis
Facial eczema and perioral dermatitis are clinical entities that develop exclusively in the face and present a special therapeutic challenge.
- Trial name
- NCT02941432
- Testing
- Black tea compress treatment
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- University of Luebeck
Hypertension
Observation of the Efficacy and Tolerance of Motens® (Lacidipine) in Patients With Essential Hypertension
Study of the efficacy and tolerance of Motens® (lacidipine) in patients with essential hypertension. To obtain information on the dosage used in practice and the tolerance at the start of treatment (12 weeks)
- Trial name
- NCT02235415
- Testing
- Motens® (lacidipine)
- Volunteers
- 24,526 people
- Sponsor
- Boehringer Ingelheim
Early-stage Breast Cancer, Hypoactive Sexual Desire Disorder
BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder
This study is open to women who have early-stage breast cancer and are on aromatase inhibitor (AI) therapy, and who have hypoactive sexual desire disorder (HSDD).
- Conditions
- Early-stage Breast Cancer, Hypoactive Sexual Desire Disorder, Hormone Receptor Positive Breast Carcinoma, Breast Cancer
- Trial name
- NCT07596212
- Testing
- Aromatase Inhibitors, Bupropion, GnRH agonist
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Illinois Chicago
Rheumatoid Arthritis
JAK-i on RA B-lymphocytes Tolerance and Disease Resolution Through JAK Signaling In Rheumatoid Arthritis
The study will reveal the transcriptomic signature linked to the aberrant activation of B lymphocytes in RA identifying novel molecular potential targets for inflammation resolution and immune tolerance promotion.
- Trial name
- NCT05754112
- Testing
- B lymphocyte profiling
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Insulin Sensitivity, Glucose Tolerance
Effect of Camel Milk on Insulin and Incretin Response
To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance
- Trial name
- NCT03725969
- Testing
- Camel milk, Cow milk
- Where
- United Arab Emirates
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Rheumatoid Arthritis (RA), Rheumatology
An Artificial Intelligence-powered Approach to Precision Immunotherapy of Human Arthritis
This clinical study is a multi-center, randomized, double-blind, placebo-controlled, outpatient study comparing the efficacy of combination of dnaJP1 peptide and hydroxychloroquine versus combination of placebo and…
- Trial name
- dnaJP1 (NCT07013110)
- Testing
- dnaJP1
- Where
- Singapore
- Volunteers
- 124 people
- Sponsor
- Prof Salvatore Albani
Skin Diseases, Infectious, Skin Diseases, Bacterial
Phase 2 Study of TR-701 in Patients With Complicated Skin and Skin Structure Infections
The purpose of the study is to determine the oral dosage of TR-701 to be used in Phase III studies in patients with complicated skin and skin structure infections.
- Trial name
- NCT00761215
- Testing
- TR-701 200 mg, TR-701 300 mg, TR-701 400 mg
- Where
- 12 sites in United States
- Volunteers
- 192 people
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Atopic Dermatitis
Safety and Efficacy of ADSTEM Inj. in Patients With Moderately Subacute and Chronic Atopic Dermatitis
This study aims to evaluate safety, tolerance, and efficacy in subjects with over moderately subacute and chronic atopic dermatitis after an intravenous injection of autologous mesenchymal stem cells.
- Trial name
- NCT02888704
- Testing
- ADSTEM Inj. (Adult human mesenchymal stem cells)
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- EHL Bio Co., Ltd.
Atopic Dermatitis
Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children
Atopic dermatitis (AD) is an immune disorder, characterized by chronic skin inflammation or relapsing, whose prevalence is increasing worldwide. Its exact etiology remains unknown.
- Trial name
- NCT02519556
- Testing
- Probiatop
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Casa Espirita Terra de Ismael
Metabolic Syndrome, Obesity
Dietary Modulation of Gene Expression and Metabolic Pathways in Glucose Metabolism
Professor Matti Uusitupa, University of Kuopio, Department of Clinical Nutrition (www.uku.fi) Docent Matej Oresic, VTT (www.vtt.fi) Ursula Schwab, PhD, Docent, Marjukka Kolehmainen, PhD, Docent, Leena Pulkkinen, PhD, Docent…
- Conditions
- Metabolic Syndrome, Obesity, Impaired Glucose Tolerance, Impaired Fasting Glucose
- Trial name
- Sysdimet (NCT00573781)
- Testing
- Diet with increased intake of rye bread, berries and fish, Increased intake of whole grain and rye bread, Control diet with decreased intake of rye bread, berries and fish
- Where
- Finland
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Rheumatoid Arthritis
Exposure Study Comparing 3 Routes of Methotrexate (MTX) Administration
Pharmacokinetics (PK) study
- Trial name
- NCT01737944
- Testing
- Methotrexate (MTX)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Antares Pharma Inc.
Asthma, Allergic Sensitization
Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children (GPAC) Study
The purpose of this study is to determine whether early childhood exposure to common allergens (substances that can trigger allergies and asthma) can prevent the development of asthma in children at high risk for developing the…
- Trial name
- GPAC (NCT00346398)
- Testing
- Oral mucosal immunoprophylaxis (OMIP)
- Where
- 3 sites in United States, Australia
- Volunteers
- 51 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)