Clinical trials: Normal Healthy
Diabetes Mellitus Type 2, Sensory Neuropathy
Evaluation of Pressure Distribution of Kyboot Shoes in Comparison to Other Foot Wear
Comparison and evaluation of pressure distribution, gait pattern, changes in the movement of the center of pressure, shock absorbing capabilities and comfort of wear using KyBoot shoes versus normal foot wear in diabetic and…
- Conditions
- Diabetes Mellitus Type 2, Sensory Neuropathy, Foot Ulcer, Diabetic
- Trial name
- Kyboot (NCT02451722)
- Testing
- Kyboot shoes
- Where
- Israel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Rheumatoid Arthritis, Non-Alcoholic Steatohepatitis
A Study to Assess the Safety and Tolerability of LB-P6 and LB-P8 in Healthy Participants
The study is designed to assess the safety and tolerability of multiple ascending doses of LB-P6 or LB-P8 in healthy participants.
- Trial name
- NCT05053165
- Testing
- LB-P6, LB-P8
- Where
- Australia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- LISCure Biosciences
Normal Healthy Volunteers Will be Treated With Lofexidine to Understand the Absolute Bioavailability and Mass Balance Recovery of the Product
Lofexidine ADME & Mass Balance in Volunteers
The purpose of this study is to determine the mass balance and absolute bioavailability of a single oral dose of 14C-labeled lofexidine compared to a single intravenous dose of lofexidine.
- Trial name
- NCT01310296
- Testing
- Lofexidine hydrochloride
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- USWM, LLC (dba US WorldMeds)
Rheumatoid Arthritis, Healthy Subjects
Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy Subjects
The purpose of this study is to determine whether fostamatinib influences the plasma concentration of warfarin and changes its blood thinning effect, and to investigate how safe and tolerable it is when administered with warfarin.
- Trial name
- NCT01311622
- Testing
- warfarin, fostamatinib
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Study to Assess the Safety, Tolerability, and Pharmacokinetics of REGN5381 (an NPR1 Agonist) in Adult Humans
The primary objective of the study is to evaluate the safety and tolerability of single intravenous (IV) doses of REGN5381 in healthy normotensive and otherwise healthy hypertensive adults.
- Trial name
- NCT04506645
- Testing
- REGN5381
- Where
- 2 sites in Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Healthy Volunteers, Effect of CPAP on Chest Movement
Effect of CPAP on Breath Hold and Chest Movement in Normal Volunteers
CPAP will be applied to normal volunteers inorder to understand CPAP's effects on breathing and chest wall motion.
- Trial name
- CPAP_normal (NCT02545686)
- Testing
- Chest wall movement assessment without CPAP, Breath hold assessment without CPAP, Chest wall movement assessment with CPAP
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Aging
Effect of Fasting on Ghrelin and Growth Hormone in Healthy Young and Older Adults
The overall objective of this study is to determine the extent to which circulating ghrelin levels (total and bioactive ghrelin) are regulated by nutritional state and age.
- Trial name
- NCT01922973
- Testing
- Fasting
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy
Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue
The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.
- Trial name
- NCT01595373
- Testing
- Acyl ghrelin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Esben Thyssen Vestergaard
Atopic Dermatitis
Safety, Tolerance and Pharmacokinetics Clinical Study of VC005 in Healthy Subjects and Patients with Mild to Moderate Atopic Dermatitis
This study is a single center, randomized, double-blind, Vehicle controlled,, single and multiple dose clinical study.
- Trial name
- NCT06009094
- Testing
- VC005
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Psoriasis
Single Ascending Dose Study of PRX003 in Healthy Subjects
This single ascending dose study is to determine safety, tolerability, pharmacokinetics and immunogenicity of PRX003 in approximately 40 healthy subjects.
- Trial name
- NCT02458677
- Testing
- PRX003
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prothena Biosciences Limited
Atopic Dermatitis
A Food Effect Study of VC005 Tablets in Healthy Adult Subjects.
This study will adopt a randomized, open-label, two-period, 2-way crossover design to evaluate Food effect of VC005 Tablets in healthy subjects
- Trial name
- NCT07533851
- Testing
- VC005 Tablets
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Healthy Volunteers, Psoriasis
A Phase 1 Study to Assess Single and Multiple Ascending Doses of PBI-100 Topical Cream
This is a Phase 1, randomized, double-blind, vehicle-controlled, SAD / MAD study evaluating three dose levels of PBI-100 topical cream in healthy adult volunteers and/or subjects with psoriasis.
- Trial name
- NCT05514353
- Testing
- PBI-100 Topical Cream, Vehicle Cream
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pyramid Biosciences
Healthy Volunteer
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers
MRG-110 is intended to promote the growth of new blood vessels by inhibiting a molecule called miR-92a. MRG-110 is being studied to determine if it can accelerate healing of wounds by improving blood flow into the wound area.
- Trial name
- NCT03603431
- Testing
- MRG-110
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- miRagen Therapeutics, Inc.
Healthy Volunteer Study
An Open-label, Non Significant Risk, Adhesive Wear Validation Study for the On Body Drug Delivery Device Component of the SQIN-01 Furosemide Infusor (Infusor Device)
The purpose of the present study is to test the adequacy, performance and skin reactivity of the adhesive tape to be utilized in the to-be-marketed Device.
- Trial name
- NCT04836572
- Testing
- 3M 1529 Adhesive Tape
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- SQ Innovation, Inc.
Breast Cancer, Tumors
Study Evaluating Ascending Single-Dose Of Bosutinib Administered With Multiple Doses Of Ketoconazole To Healthy Subjects
The purpose of this study is to assess the safety and tolerability of ascending single oral doses of bosutinib administered with multiple doses of ketoconazole and to provide the pharmacokinetic profile of bosutinib when…
- Conditions
- Breast Cancer, Tumors, Leukemia
- Trial name
- NCT00777530
- Testing
- Bosutinib (SKI-606)
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Healthy, Chronic Rhinosinusitis With Nasal Polyps
Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis
The purpose of this study is to evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06817024 in healthy volunteers, in participants with chronic rhinosinusitis, with nasal polyps and in participants with…
- Conditions
- Healthy, Chronic Rhinosinusitis With Nasal Polyps, Atopic Dermatitis
- Trial name
- NCT02743871
- Testing
- PF-06817024
- Where
- 20 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus
NOX-E36 First-in-Human (FIH) Study
This is the first time NOX-E36 will be administered to man. The principal aim of this study is to obtain safety and tolerability data when NOX-E36 is administered by single intravenous (IV) and subcutaneous (SC) doses to healthy…
- Conditions
- Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus, Systemic Lupus Erythematosus
- Trial name
- NCT00976729
- Testing
- NOX-E36
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Diaper Rash
Infant Microbiome in Diaper Rash
The objective of this study is to evaluate the microbiome composition of infant's (9-12 month) skin experiencing diaper rash in order to determine if the onset and severity of erythema associated with diaper rash is influenced by…
- Trial name
- NCT02893501
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Kimberly-Clark Corporation
Psoriasis
Single Cell Genomics of Psoriatic Skin
The purpose of this study is to understand how genetics play a role in psoriasis. Specifically, a genetic allele HLA-Cw6 is known to be associated with psoriasis, and this study aims to find out how it affects genetic and protein…
- Trial name
- NCT02929745
- Testing
- Skin biopsy, Blood draw
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tourette Syndrome, Tic Disorders
Study of Tics in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder
This study will investigate which areas of the brain are primarily involved in and responsible for tics in patients with Tourette's syndrome and chronic motor disorder.
- Trial name
- NCT00033995
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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