Clinical trials: Normal Healthy Subjects
Diabetes Mellitus, Hyperkeratosis
Instrumental Assessment of Plantar Hyperkeratosis in Healthy Subjects and Patients With Diabetes
This randomized clinical trial aims to compare the diagnostic performance, reproducibility, and agreement of several non-invasive instrumental methods for assessing plantar hyperkeratosis hardness in healthy subjects and patients…
- Trial name
- NCT07412561
- Testing
- Instrumental Assessment of Plantar Hyperkeratosis
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Seville
Brain Injury, Dementia
Neuropsychiatric Evaluation of Healthy Volunteers and Adults With Schizophrenia
The purpose of this study is to evaluate the cognitive processes of participants with schizophrenia, participants with nervous system and mental disorders, and healthy volunteers.
- Conditions
- Brain Injury, Dementia, Healthy, Mental Disorder
- Trial name
- NCT00001323
- Where
- United States
- Volunteers
- 810 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Psoriasis
A Clinical Trial of TQH3906 Capsules in Healthy Volunteers
This study was divided into three parts: single and multiple dosing and food effect study, which were designed to evaluate the safety and tolerability of TQH3906 capsules administered in single or multiple dose escalation in…
- Trial name
- NCT06230588
- Testing
- TQH3906 capsule
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Psoriasis
Trial of HSK44459 Cream for the Management Plaque Psoriasis
Phase I Study Objectives: Primary: Assess the safety and tolerability of HSK44459 cream in 10 healthy adult participants and 10 patients with plaque psoriasis.
- Trial name
- NCT07623486
- Testing
- HSK44459 Cream, Vehicle
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Herpes Simplex Virus Infection
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of UB-621 in Healthy Volunteers
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of a single subcutaneous dose of UB-621 in healthy volunteers.
- Trial name
- NCT02346760
- Testing
- UB-621
- Where
- Taiwan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United BioPharma
Healthy
Multi-Dose Safety and Pharmacokinetic Study of S-Equol in Healthy Volunteers
The purpose of this study is to evaluate the safety and tolerability of escalating multiple doses of S-equol administered twice daily (BID) for 14 days to healthy male and female subjects and to describe the pharmacokinetic…
- Trial name
- NCT00998920
- Testing
- S-equol
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Ausio Pharmaceuticals, LLC
Oxygen Deficiency
Validation of the O3 Regional Somatic Tissue Oxygenation Monitor
Testing the absolute accuracy of the Masimo O3 regional oximeter in reading somatic tissue oxygenation in healthy volunteers under controlled hypoxia.
- Trial name
- NCT04584788
- Testing
- Masimo O3 Regional Oximeter
- Where
- Netherlands
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Friedreich Ataxia
A Single Ascending Dose Study of DT-216P2 in Normal Healthy Participants
This purpose of the study is to evaluate the safety, tolerability and pharmacokinetics of single ascending doses of DT-216P2 administered either subcutaneously (SC) and intravenously (IV) in normal healthy participants.
- Trial name
- NCT06772870
- Testing
- DT-216P2, Saline
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Design Therapeutics, Inc.
Chronic Spontaneous Urticaria
Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Immunogenicity of UB-221 in Healthy Volunteers
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of a single dose of UB-221 in healthy volunteers.
- Trial name
- NCT04404023
- Testing
- UB-221
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- UBP Greater China (Shanghai) Co., Ltd
Healthy, Adrenal Insufficiency
Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test
Objectives: To establish valid serum total cortisol and salivary cut-offs for use with the short Synacthen test in patients with normal CBG concentrations.
- Conditions
- Healthy, Adrenal Insufficiency, Hypopituitarism
- Trial name
- NCT00851942
- Testing
- Synacthen (Tetracosactrin)
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Diabetes Mellitus Type 2, Sensory Neuropathy
Evaluation of Pressure Distribution of Kyboot Shoes in Comparison to Other Foot Wear
Comparison and evaluation of pressure distribution, gait pattern, changes in the movement of the center of pressure, shock absorbing capabilities and comfort of wear using KyBoot shoes versus normal foot wear in diabetic and…
- Conditions
- Diabetes Mellitus Type 2, Sensory Neuropathy, Foot Ulcer, Diabetic
- Trial name
- Kyboot (NCT02451722)
- Testing
- Kyboot shoes
- Where
- Israel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Rheumatoid Arthritis
A Study of KD6005 in Healthy Participants and Participants With Rheumatoid Arthritis (RA)
This phase 1 study will consist of two parts: Phase 1a is a single-dose study, and will evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary pharmacodynamics (PD) in healthy participants.
- Trial name
- NCT06213259
- Testing
- KD6005
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Shanghai Kanda Biotechnology Co., Ltd.
Asthma, COPD
An Evaluation of 9MW1911 Injection in Healthy Subjects
This study is a randomized, double-blind, dose-escalating phase I clinical study to evaluate the safety, tolerability and pharmacokinetics of 9MW1911 injection in healthy subjects.
- Conditions
- Asthma, COPD, Atopic Dermatitis
- Trial name
- NCT05803902
- Testing
- Experimental drug 9MW1911
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Safety Issues
Safety and Pharmacokinetics of NP10679 in Normal Healthy Volunteers
This study assesses the safety, tolerability and pharmacokinetics of NP10679 when delivered intravenously in escalating dose levels in comparison to placebo.
- Trial name
- NCT03565861
- Testing
- NP10679
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Neurop Inc.
Normal Physiology, fMRI
The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans
Background: Two areas on the surface of the brain, the dorsolateral prefrontal cortex (DLPFC) and motor cortex (MC), play a key role during learning.
- Trial name
- NCT01260740
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy, Coronary Artery Disease
Dose Finding Study of PB127 Ultrasound Contrast Agent in Healthy Volunteers and Patients With Coronary Artery Disease
The purpose of this study is to determine the dose of PB127 for detection and/or exclusion of coronary artery disease when used with cardiac ultrasound. This study also evaluates the safety of PB127.
- Trial name
- NCT00584818
- Testing
- PB127 for Injectable Suspension
- Where
- 16 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Point Biomedical
Systemic Lupus Erythematosus
A Study to Estimate the Relative Bioavailability, Tolerability and Safety of a Single Dose of Belimumab Self-Administered Subcutaneously (SC) by Healthy Subjects
This will be a randomized, parallel-group, open-label, single-dose study of belimumab in healthy subjects to estimate the relative bioavailability, tolerability and safety of a single dose of belimumab 200 milligram (mg) when…
- Trial name
- NCT01894360
- Testing
- Belimumab 200 mg/mL
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Fasting
Bioequivalence Study of Bisoprolol Fumarate Tablet 10 mg Under Fasting Condition
This is a randomized, open Label, balanced, two-treatment, two-period, two-sequence, single dose, crossover pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding…
- Trial name
- NCT01741623
- Testing
- Bisoprolol Fumarate Tablet 10 mg, Bisoprolol
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- IPCA Laboratories Ltd.
Healthy Subjects
Pharmacokinetics and Bioavailability of Single Subcutaneous Doses of Methylnaltrexone Versus Intravenous Dose
This is an open-label, Phase I study. Study treatments will entail a four-way crossover among three single, ascending, subcutaneous doses and one intravenous dose of MNTX in six healthy normal male volunteers.
- Trial name
- NCT01367496
- Testing
- SC Methylnaltrexone (MNTX), IV Methylnaltrexone (MNTX)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Fed
Bioequivalence Study of Risperidone Tablet 1 mg Under Fed Condition
This is a randomized, open Label, balanced, two-treatment, two-period, two-sequence, single dose, crossover pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding…
- Trial name
- NCT01618760
- Testing
- Risperidone Tablet 1 mg, Risperidone
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- IPCA Laboratories Ltd.
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