Clinical trials: Normal Physiology
Normal Physiology
Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli
Background: An electroencephalogram (EEG) measures the brain s electrical activity. EEG shows that the louder the sound needed to wake a person, the deeper the person s sleep.
- Trial name
- NCT02629107
- Where
- United States
- Volunteers
- 2,378 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Obesity, Normal Physiology
The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure
Background: Diet-induced thermogenesis (DIT) is the amount of energy one's body uses to eat food, absorb the nutrients from the food, and process those nutrients.
- Conditions
- Obesity, Normal Physiology, Healthy Volunteers
- Trial name
- NCT05545306
- Testing
- +200% of dietary requirements, 50% of calories from carbohydrates, 20% from protein, and 30% from fat, fasting, -50% of energy balance requirements. 50% of calories from carbohydrates, 20% from protein, and 30% from fat
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Normal Physiology
Energy Expenditure Responses to Different Temperatures
Background: The way that the body burns calories is known as energy expenditure. Some studies show that when we are cold, we burn more calories to keep our bodies warm.
- Trial name
- NCT01568671
- Testing
- Room temperatures
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Normal Physiology
Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms
The goal of this clinical trial is to learn how the pupil responds to different light stimuli and how that relates to sleep and daily rhythms in healthy people of different ages.
- Trial name
- NCT05829044
- Testing
- Pupillometry, Light box exposure
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Normal Physiology
NIEHS Repository of Stored Biological Samples for Future Use
Background: Laboratory tests that use blood and urine can provide a great deal of information about human health and disease. To develop even better tests and to improve the ways samples are handled for testing researchers need…
- Trial name
- NCT05666739
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Normal Pediatric Swallowing Physiology, Swallowing Muscle Activation Patterns in Children
Surface Electromyographic Analysis of Normal Swallowing in Children: An Exploratory Study
This exploratory clinical trial aims to investigate the mechanism of sequential muscle contractions during normal swallowing processes, including spoon, straw, and cup feeding, in children aged 2 to under 10 years without…
- Conditions
- Normal Pediatric Swallowing Physiology, Swallowing Muscle Activation Patterns in Children, Swallowing Function
- Trial name
- NCT07455279
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Cancer Diagnosis, Liver Cancer, Adult
Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis
The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening.
- Conditions
- Cancer Diagnosis, Liver Cancer, Adult, Cancer Screening, Colorectal Cancer (CRC)
- Trial name
- NCT06822413
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Normal Physiology, Stroke
Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation
Background: After a stroke, the balance between the two halves of the brain can be lost. This may cause people to lose the ability to perceive a side of space. This is called neglect.
- Trial name
- NCT02911129
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Physiology, Amnestic Mild Cognitive Impairment
MRI Guided Closed-loop TMS-EEG
The goal of this interventional study is to develop an individualized approach using transcranial magnetic stimulation (TMS) in a high-precision manner.
- Trial name
- NCT06050603
- Testing
- TMS
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Normal Physiology
Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI
Background: Dopamine (DA) is a chemical signal in the brain linked to learning, memory, and habits. Stimulant drugs like methylphenidate can increase DA in the brain. Researchers want to measure DA with and without this drug.
- Trial name
- NCT03326245
- Testing
- Methylphenidate Pill, Intravenous methylphenidate
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Normal Physiology
Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis
Background: 'Free will' can be defined as the belief that people have control over their thoughts and movements. The topic of free will is controversial and is still being debated.
- Trial name
- NCT04344470
- Testing
- EMG, EEG
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Endometrial Physiology
Endometrial Basis for Infertility in Women With Recurrent Implantation Failure and Pregnancy Loss
Background: Pregnancy loss is the most common complication of pregnancy. It occurs in roughly one-half of natural conceptions. It most frequently occurs in the first 2 to 3 weeks of pregnancy.
- Trial name
- NCT04939064
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Normal Physiology
Neurophysiology of Surround Inhibition in the Human Motor Cortex
Background: Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement.
- Trial name
- NCT03018262
- Testing
- TMS - sub-study 1, TMS - sub-study 2, TMS - sub-study 3
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder
Characterization and Brain Mechanisms of Frustration in Youth With Severe Irritability or Attention Deficit Hyperactivity Disorder (ADHD)
Background: Irritability is an elevated proneness to anger. Children with irritability have difficulty tolerating frustration. They get angry and have temper outbursts more easily than their others their age.
- Conditions
- Disruptive Mood Dysregulation Disorder, Attention Deficit Hyperactivity Disorder, Normal Physiology
- Trial name
- NCT05357495
- Testing
- Affective Posner fMRI frustration induction task
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Normal Physiology
Exploring the Relationship Between Brain Asymmetry and Attention
Background: People tend to pay more attention to one side of space than the other and this may be due to differences in the structure and function of the two sides of the brain.
- Trial name
- NCT03789201
- Testing
- TMS EEG, TMS fMRI
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Physiology
Collection of Peripheral Blood Stem Cells Using G-CSF and Plerixafor in Normal Volunteers
Background: Many treatments for immune system disorders involve the use of stem cells that have been collected from blood marrow.
- Trial name
- NCT01123499
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteers, Normal Physiology
Reference Values for Plasma Catechols
Objectives: Plasma levels of catechols have distinct meanings in terms of indicating functions of endogenous catecholamine systems.
- Trial name
- NCT00267904
- Testing
- Coffee, Banana, Olives
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Physiology
Sensory Afferents for Deep Pressure Sensation
Background: Much is known about how people perceive light touch, temperature, and pain. But less is known about how deep pressure is perceived. Deep pressure is an important part of many touch therapies, like massage therapy.
- Trial name
- NCT03937778
- Testing
- Deep pressure block
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Normal Physiology
Volunteer Screening for Vaccine and Antivirals Clinical Trials
Background: Vaccines and antiviral therapies are critical for preventing and treating viral diseases. Testing these vaccines and drugs often requires healthy volunteers.
- Trial name
- NCT01593709
- Where
- United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Normal Physiology
Pharmacokinetics of Granulocyte Colony Stimulating Factor in the Breast Milk of Volunteer Peripheral Blood Stem Cell Donor
Background: The drug filgrastim (rGCSF) increases the number of blood-forming cells in the bloodstream. These cells can be collected from donors bloodstreams and used for transplant.
- Trial name
- NCT02322151
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)