Clinical trials: Normal Pressure Hydrocephalus
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
The iNPH Patients Scheduled for VP or LP Shunt Procedures
Factors Associated With Post-induction Hypotension in iNPH Patient Undergoing VP and LP Shunt
This study is a retrospective work involving the review of patients who were scheduled for VP or LP shunt in Siriraj Hospital, Mahidol University, Thailand.
- Trial name
- NCT05183061
- Testing
- Ehedrine Norepineprine
- Where
- Thailand
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic
Unsteady Gait in Older People May be a Common and Treatable Neurological Disease Associated With Increased Mortality
We live in an aging population and a third of the older population has a gait disorder that may cause institutionalization, and increased mortality.
- Conditions
- Idiopathic Normal Pressure Hydrocephalus (INPH), Gait Disorders, Neurologic, Gait Disorders in Old Age
- Trial name
- VESPR2 (NCT07137403)
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Umeå University
Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus
Clinical Outcome in Patients With INPH
The aim of this study is to determine the clinical spectrum and natural progression of idiopathic normal pressure hydrocephalus （iNPH ) and related disorders in a prospective single center study, identify digital, imaging and…
- Conditions
- Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus, CSF, Glympathic System
- Trial name
- NCT06428734
- Testing
- hydrocephalus group, normal group
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Hydrocephalus, Normal Pressure, Ventriculomegaly, Cerebral
Volumetrics and Proteomics in Shunted Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (=iNPH) is a condition with disturbed circulation of cerebrospinal fluid (=CSF) causing symptoms such as balance and gait disorders, urinary incontinence and cognitive impairment in…
- Conditions
- Hydrocephalus, Normal Pressure, Ventriculomegaly, Cerebral, Shunt; Complications, Hydrocephalus Acquired
- Trial name
- LiNPH (NCT04785560)
- Testing
- Initial shunt setting post-operatively of the Certas Plus shunt valve.
- Where
- Sweden
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Normal Pressure Hydrocephalus
The Brain Structure and Neural Network Changing the Before and After Ventriculo-peritoneal Shunting in the Normal Pressure Hydrocephalus Patients
With the advent of the aging society, dementia becomes the focus of common people. As for the neurodegeneration dementia, no disease modifying treatments have been discovered.
- Trial name
- NCT03092804
- Testing
- ventriculo-peritoneal shunting
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hydrocephalus, Parkinson Disease
Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease
This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant…
- Conditions
- Hydrocephalus, Parkinson Disease, Walking, Difficulty, Movement Disorders
- Trial name
- HPGAIT (NCT05998473)
- Testing
- Dynamic stability measurement
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henri Mondor University Hospital
Normal Pressure Hydrocephalus
White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)
Idiopathic Normal Pressure Hydrocephalus (iNPH) is a progressive condition of the elderly that results in severe disability. iNPH can dramatically respond to Cerebral spinal fluid(CSF)-shunting where excess ventricular fluid is…
- Trial name
- OWN-NPH (NCT07103681)
- Testing
- Ventriculoperitoneal Shunt (VP), Brain and Skin Biopsy, MRI Brain
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Idiopathic Normal Pressure Hydrocephalus
Gait Pattern and Experienced Global Change After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus
Part 1 Patients with idiopathic Normal Pressure Hydrocephalus (iNPH) have variable disabilities regarding gait, balance, cognition and continence.
- Trial name
- NCT04795089
- Testing
- Shunt surgery
- Where
- Sweden
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Idiopathic Normal Pressure Hydrocephalus (INPH)
Walking Pattern Characteristics in Normal Pressure Hydrocephalus
20 patients who are diagnosed with NPH receive a set of 5 wearable gyroscopes (IMUs, ZurichMove sensors) for a period of 3 days for measurement and characterization of their walking in an ambulatory setting.
- Trial name
- NPH wearables (NCT04702035)
- Testing
- Characterization of walking pattern characteristics in an ambulatory setting using wearable IMUs (ZurichMOVE sensors)
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Parkinson Disease, Multiple System Atrophy
A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies
This will be an observational study looking at clinical and biomarker characteristics in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Rapid Eye Movement Sleep Behavior Disorder (RBD), Normal Pressure…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Rapid Eye Movement Sleep Behavior Disorder, Normal Pressure Hydrocephalus
- Trial name
- NCT04020198
- Testing
- Biomarker assay
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Intracranial Pressure
New Reference Values for Intracranial Pressure
Intracranial pressure is a cornerstone in neurosurgical care used in a variety of diseases. However currently, doubts regarding normal intracranial pressure exist.
- Trial name
- NCT03594136
- Testing
- Raumedic Neurovent-P-tel
- Where
- 3 sites in Czechia, Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Normal Pressure Hydrocephalus, Hydrocephalus
European Study of Prodromal iNPH
To investigate if progression from prodromal into symptomatic NPH can be predicted from advanced neuroimaging, biomarkers in cerebrospinal fluid (CSF) and plasma and investigate the unknown mechanisms causing deterioration by…
- Trial name
- STOP iNPH (NCT05910944)
- Testing
- Shunt surgery
- Where
- 7 sites in Finland, Italy and 1 more
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Johan Virhammar
Normal Pressure Hydrocephalus
Cerebrospinal Fluid Proteome in Hydrocephalus
PROLIPHYC is a collaborative prospective study that aims at discovering deep cerebrospinal fluid (CSF) proteome with a new clinically-compatible proteomics strategy, in a cohort of 100 patients suspected of neurodegenerative…
- Trial name
- PROLIPHYC (NCT02016352)
- Testing
- patient CSF extraction with hydrocephalus, witness CSF extraction
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Hydrocephalus, Normal Pressure Hydrocephalus
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
The goal of this observational study is to evaluate the role of DTI-ALPS in the diagnostic and therapeutic management of NPH The main questions it aims to answer are: Whether the glymphatic system (GS) is actually impaired in NPH…
- Trial name
- GLINFANPH_2021 (NCT06857136)
- Where
- Italy
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Alzheimer Disease, Frontotemporal Dementia
Proteinopathies Expression in Skin of Neurodegenerative Disorders
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 [TDP43]) in skin biopsies of…
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease, Atypical Parkinsonism
- Trial name
- NCT06528964
- Testing
- Immunohistochemistry and immunofluorescence
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Normal Pressure Hydrocephalus
Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)
A computerised neuropsychological test battery to be used as a standardised tool assessing the cognitive domains affected by idiopathic normal pressure hydrocephalus INPH was developed.
- Trial name
- NCT01265251
- Testing
- Computerized neuropsychological test, Conventional neuropsychological test
- Where
- Sweden
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Umeå University
Fecal Incontinence with Fecal Urgency, Urine Incontinence
Idiopathic Normal Pressure Hydrocephalus: Focus on Imaging and Clinical Symptoms.
LiNPH is a prospective single center clinical and radiological study.
- Conditions
- Fecal Incontinence with Fecal Urgency, Urine Incontinence, Diffusion Tensor Imaging, Leukoencephalopathies
- Trial name
- LiNPH (NCT04808076)
- Testing
- Shunt surgery
- Where
- Sweden
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Normal Pressure Hydrocephalus, Hakim Syndrome
Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland
The study aims to estimate Normal Pressure Hydrocephalus (NPH) prevalence and evaluate health equity gaps in Baltimore and Maryland based on zip codes and race, with a focus on the Black community.
- Trial name
- NPH (NCT06426004)
- Testing
- patients will receive NPH education, primary care physicians (PCPs) will receive professional NPH education, A community health worker will assist PCP
- Where
- 2 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health