Clinical trials: Normal Skin
Rheumatoid Arthritis
Fexofenadine in Patients With Active Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an inflammatory autoimmune polyarthritis affecting ∼1% of the world population, resulting in the loss of joint function and progressive structural damage in affected joints.
- Trial name
- NCT05264025
- Testing
- Fexofenadine
- Where
- 2 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- October 6 University
Autism Spectrum Disorder
The Effect of Hepatic Impairment on the Pharmacokinetics of Balovaptan
This is a multi-center, non-randomized, open-label, parallel group, multiple-dose study to assess the pharmacokinetic, safety, and tolerability of balovaptan in male and female subjects with moderate hepatic impairment compared…
- Trial name
- NCT03912350
- Testing
- Balovaptan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Staphylococcal Infections
Evaluation of Consistency of StaphVAX Manufacturing Lots
This study answers a U.S. Food and Drug Administration requirement for evaluation in people of the consistency of manufacturing of a vaccine. Subjects are randomized to one of three lots of vaccine.
- Trial name
- NCT00211991
- Testing
- S. aureus Type 5 & 8 Capsular Polysaccharide Conjugate
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Nabi Biopharmaceuticals
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy Adult Subjects
A Comparative Pharmacokinetic Study of ADL-018 Autoinjector Compared to A Pre-filled Syringe in Healthy Subjects.
The Goal of these study is to assess the comparative pharmacokinetics of Test Product (A): ADL-018 Injection 150 mg/mL solution in a single dose pre-filled autoinjector, manufactured by Kashiv Biosciences LLC, USA with Reference…
- Trial name
- NCT06929052
- Testing
- ADL-018 Autoinjector, ADL-018 Injection
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kashiv BioSciences, LLC
Cardiorespiratory Fitness, Eye Disorders
Ralation Between Cardiorespiratory Fitness and Mean Corrected Intraocular Pressure
Objective: To investigate the association between cardiorespiratory fitness and mean corrected intraocular pressure (IOP) in a normotensive health check-up population, and to evaluate potential differences across age and sex…
- Trial name
- NCT07676747
- Testing
- Mean corrected intraocular pressure (IOP) of both eyes
- Where
- China
- Volunteers
- 2,921 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences
Moderate Liver Impairment, Severe Liver Impairment
A Study to Evaluate the Drug Levels, Safety, and Tolerability of BMS-986036 in Participants With Normal Liver Function and Participants With Moderate and Severe Liver Impairment
The purpose of this study is to investigate the effect of impaired liver function on the drug levels, safety, and tolerability of BMS-986036 in participants with moderate and severe liver impairment.
- Trial name
- NCT04634149
- Testing
- BMS-986036
- Where
- 3 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Normal Drug Tolerance
Safety and Pharmacokinetic (PK) Study to Assess Bronchopulmonary Disposition of IV Eravacycline (TP-434) in Healthy Men and Women
This is a phase 1, open-label, randomized pharmacokinetic and safety study in healthy adult subjects, who will undergo bronchoscopy and bronchoalveolar lavage (BAL) after receiving seven (7) doses of 1.0 mg/kg IV TP-434.
- Trial name
- BAL (NCT01989949)
- Testing
- TP-434 (Eravacycline) reconstituted and administered via an IV infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tetraphase Pharmaceuticals, Inc
Breast Neoplasms Diagnosis
Breast Cancer Risk Assessment in Night Shift Workers - Implementation of a Personalized Consultation
This study evaluates adherence to a personalized prevention plan in female night shift workers at increased risk of breast cancer.
- Trial name
- NIGHT-SCAN (NCT07630935)
- Testing
- Personalized Prevention Plan
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Microcirculation; Biomarkers; Myocardial Ischemia
Endothelial and Microvascular Functions in Patients With Myocardial Ischemia
Cardiovascular diseases (CVD) are responsible, throughout the world, for high mortality rates and cardiovascular morbidity. Endothelial dysfunction is the earliest marker of clinical atherosclerosis development.
- Trial name
- NCT03243968
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Musculoskeletal Pain, Rheumatologic Disorder
Satisfaction, QoL,Health Status & Clinic Outcomes for Patients Attending MSK Triage Clinics in Rheumatology
The aim of this study is to measure the impact of musculoskeletal (MSK) complaints on the quality of life and general health of MSK Patients attending MSK triage clinics.
- Trial name
- NCT04244968
- Where
- Ireland
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Health Service Executive, Ireland
Renal Impairments
A Study to Evaluate EDG-7500 in People With Renal Impairment
The purpose of this Phase 1 study is to understand and compare the amount of EDG-7500 in the blood after a single dose in participants with different levels of kidney function impairment versus participants with normal kidney…
- Trial name
- NCT07034768
- Testing
- EDG-7500
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Edgewise Therapeutics, Inc.
Autism Spectrum Disorders, Normal Hearing
The Effects of ProFoveate on Reducing Self-Stimulating Behaviors
This study is designed to pilot an intervention technique to reduce the self-stimulating behaviors seen in individuals with autism spectrum disorders using intervention with ProFoveate pellets.
- Conditions
- Autism Spectrum Disorders, Normal Hearing, Normal Intelligence, Exhibit Self- Stimulating or Ritualistic Behaviors
- Trial name
- NCT02088047
- Testing
- ProFoveate
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
End-Stage Renal Disease (ESRD)
A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD)
The primary objective of the study is to evaluate the pharmacokinetics (PK) of avacopan and metabolite (M1) after a single dose of avacopan in participants with normal renal function and participants with ESRD requiring…
- Trial name
- NCT06468826
- Testing
- Avacopan
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Amgen
Temporomandibular Joint Disorders, Rheumatoid Arthritis
Temporomandibular Joint in Patients With Rheumatoid Arthritis
the investigators study aimed to evaluate temporomandibular joint involvement in rheumatoid arthritis patients and healthy individuals 142 participants were recruited in two groups: 72 patients with Rheumatoid Arthritis (RA), and…
- Trial name
- NCT06134726
- Testing
- seropositivity of rheumatoid factor
- Where
- Syria
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Syrian Private University
Breast Cancer
BREAST Choice Decision Tool R21 - AIM2
Breast reconstruction is a critical component of breast cancer treatment because it restores quality of life and body image after mastectomy.
- Trial name
- BREASTChoice (NCT06817226)
- Testing
- Pre-survey, BREASTChoice tool., Post-survey
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cartilage Diseases
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy.
- Trial name
- NCT01006278
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scuderi, Gaetano J., M.D.
HPV Infections
A Study to Identify Markers in Blood and Tissue of HPV Clearance
This is a research study looking at gene characteristics in blood and Pap smear samples in hopes of identifying markers that will predict if the HPV infection is present or not.
- Trial name
- NCT00711815
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
High-Risk Breast Duct Epithelium
Background: Breast cancer is the most common malignancy in women, occurring in over 230,000 women annually in the United States.
- Trial name
- NCT00028340
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Hunger
The Effect of Television Watching on Liking of Food
The purpose of the study is to investigate the effect of television viewing on liking of food.
- Trial name
- NCT02505490
- Testing
- Television, No Television
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
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