Clinical trials: Normal-weight Obesity
Cardiovascular Risk Factor, Cardiovascular Diseases
Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults
The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Diabetes, Physical Activity
- Trial name
- NCT03898206
- Testing
- Breaking up sitting with walking breaks (INT-SIT), Prolonged sitting (SIT)
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Bedfordshire
Breast Cancer
Using Technology to Improve Physical Activity Levels Among Postmenopausal Women (The Active & Aware Study)
Women who are overweight or do not exercise are at higher risk for breast cancer after menopause. This study will test a new electronic device that measures the body's movement and works alongside a website to help women increase…
- Trial name
- NCT01837147
- Testing
- Technology-Based Physical Activity Promotion, Pedometer Intervention
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Normal Weight, Overweight and Obesity
Effect Cinnamon Spice on Postprandial Glucose and Insulin Responses
The objective of the proposed study is to investigate the effect of cinnamon on the postprandial glycemic response to a high glycemic index meal in normal and overweight/obese prediabetic subjects
- Trial name
- CINNI (NCT04686552)
- Testing
- cinnamon
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Fractures, Bone, Bone Marrow Disease
Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women
The purpose is to determine in a case-control study if an association exist between bone marrow adiposity and fragility fractures in post-menopausal women.
- Conditions
- Fractures, Bone, Bone Marrow Disease, Fat Disorder, Adiposity
- Trial name
- ADIMOS (NCT03219125)
- Testing
- Dixon Magnetic Resonance Imaging, dual-energy X-ray absorptiometry (DXA)
- Where
- France
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Weight Loss
Effects of Two Weeks of 5:2 Intermittent Energy Restriction on Basal and Postprandial Metabolism
Worldwide, a third of adults were overweight in 2016, and 13% were obese. Excess energy intake results in weight gain. Excess fat increases the risk of disease (eg.
- Trial name
- NCT04138160
- Testing
- 5:2 Intermittent energy restriction, Continuous energy restriction
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Aging, Obesity
Resistance Exercise Training in the Older Population With Obesity
Background: Aging leads to an alteration in the immune response, characterized by a chronic inflammatory state, and a progressive decrease in muscle quantity and quality, a situation that increases in women and in the presence of…
- Trial name
- RETOPO (NCT06367296)
- Testing
- Prolonged resistance exercise training
- Where
- 2 sites in Chile
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Insulin Resistance, Obesity
Adipose Tissue Response to Overfeeding in Insulin Resistance-Prone vs. Insulin Sensitive Humans
Obesity has become an epidemic worldwide. Data from our laboratory and others demonstrate that most of the excess morbidity from obesity is related to insulin resistance (IR).
- Trial name
- NCT02084641
- Testing
- Over feeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stanford University
Lipedema, Obesity & Overweight
Ultrasonographic Evaluation and Pedobarographic Correlation of Lower Extremity Muscles in Lipedema Patients
The primary aim of this study is to evaluate the lower extremity muscle structure, lower extremity alignment, and foot posture in lipedema; secondly, to reveal the chain relationship and biomechanical problems that may be…
- Trial name
- PODUSG (NCT07724483)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Marmara University
Obesity, Type 2 Diabetes Mellitus
The Influence of Fatty-Acids on Systemic and Subcutaneous Cytokines
This is a mono-center randomized controlled trial to be performed in the Center of Medical Research (ZMF) at Medical University Graz and is composed by one screening visit (V1) and two study visits (V2 and V3).
- Trial name
- TNF4 (NCT00708266)
- Testing
- Openflow microperfusion catheter, Intralipid 20%, 0.9% Saline Solution
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Appetitive Behavior, Pediatric Obesity
IL-6 in Exercise-Induced Anorexia
This study investigates the effect of high intensity exercise, with and without the inflammation inhibitor, ibuprofen, on plasma levels of IL-6 and other selective biomarkers of inflammation and appetite on food intake and…
- Trial name
- NCT03295968
- Testing
- High Intensity Exercise/Ibuprofen
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Exercise
Exercise Training and Insulin Sensitivity
Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans.
- Trial name
- NCT05930834
- Testing
- exercise
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Abdominal, Feeding Patterns
Circadian Rhythms in Human Adipose
The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.
- Trial name
- NCT06891534
- Testing
- Continuous Feeding, Intermittent feeding
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight, Obesity
Role of Dietary Protein on Satiety, Food Intake and Thermic Effect of Food
Objectives: To determine the effect of protein content of familiar breakfast meals on subjective appetite, food intake (FI), glycemic response and Thermic Effect of Food (TEF) in normal weight (NW) and overweight (OW)/obese (OB)…
- Trial name
- NCT02200796
- Testing
- Control Meal, Low Protein Meal, Moderate Protein Meal
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Obesity
The Significance of Vitamin D Storage in Adipose Tissue
The study will examine the role of adipose tissue in vitamin D physiology, particularly its role as a depot. the study is randomized double blind and placebo controlled.
- Trial name
- NCT01728987
- Testing
- cholecalciferol
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tromso
Obesity
The Role of Atrial Natriuretic Peptide in the Lipolytic Process: Effect of Obesity and Exercise
In the developing countries, obesity prevalence is on a dramatic rise. Obesity is related to co-morbidities and as a result, obesity significantly shortens life expectancy and lowers quality of life.
- Trial name
- BALO (NCT02418728)
- Testing
- subcutaneous adipose tissue microdialysis under local beta/alpha blockade
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Normal-weight Obesity, Obesity
Exercise-Induced Gut Permeability in Normal-weight Obesity
Exercise acutely increases gut permeability and inflammation, even in healthy populations. However, whether this response differs in groups at-risk for CVD that present with low-grade inflammation (e.g., normal-weight obesity)…
- Trial name
- NCT05889767
- Testing
- Exercise tests (VO2 max test and 45-minute exercise session at 65% VO2 max)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Mitochondrial Diseases, Obesity
Muscle OXPHOS and Nutrient Homeostasis
Investigators are recruiting adults (men and women, ages 18 to 65 years, inclusive) with a confirmed genetic diagnosis of mitochondrial disease.
- Trial name
- NCT02920671
- Testing
- Tracer-enhanced oral glucose tolerance test (OGTT*), Muscle MRI, Dual energy x-ray absorptiometry (DXA)
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity, Colon Cancer
Proteomic Analysis of Patients Undergoing Bariatric Surgery
The expression of proteins in the blood of obese individuals is different from the expression of proteins in healthy individuals, and is also different in individuals after bariatric surgery.
- Conditions
- Obesity, Colon Cancer, Thyroid Cancer, Esophageal Cancer
- Trial name
- NCT06787807
- Testing
- bariatric surgery
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Metabolism Disorder, Adiposity
Effect of Exercise and Omega-3 on Metabolic Health in Elderly
The aim of this project is to investigate in elderly women, the effect of combined aerobic and resistive training and concomitant supplementation with omega-3 fatty acids on adipogenesis, metabolic functions and pro-inflammatory…
- Conditions
- Metabolism Disorder, Adiposity, Inflammatory Response
- Trial name
- EXODYA (NCT03386461)
- Testing
- Exercise training, omega 3 supplementation
- Where
- Czechia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Healthy, Obesity
Sex Differences in Gene Expression in Human Adipose Tissue
This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand: 1.
- Trial name
- NCT00677651
- Testing
- Adipose Biopsy, Blood sample, CT Scan
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego