Clinical trials: Normal-weight Obesity
Heart Failure With Preserved Ejection Fraction, Obesity
PErirenal Adipose Tissue and RenaL Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction
Rationale: Perirenal adipose tissue (PRAT) thickness has been associated to worsening renal function and hypertension. The role of PRAT in heart failure with a preserved ejection fraction (HFpEF) has never been established.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Obesity, Renal Insufficiency
- Trial name
- PEARL-HFPEF (NCT05219188)
- Testing
- 3.7 mS, CT radiation
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Lipodystrophy, Obesity
Hemoglobin Level, Coagulopathy Profile and Electrolyte Balance
What is Impact of Amount Versus Surface Area of Liposuction on Haematological Parameters, Coagulopathy Profile and Electrolyte Balance? Liposuction involves the creation of extensive subsurface trauma, comparable in many respects…
- Trial name
- NCT04656054
- Testing
- liposuction
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alaa Hassan M. Elhawary
Obesity, Vascular Dysfunction
DNA Methylation and Vascular Function
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for…
- Trial name
- NCT03527420
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Overweight and Obesity, Exercise
Establishment of the 2H-labeling Protocol at Pennington Biomedical Research Center
A method has been developed to measure in vivo adipose kinetics and turnover rates, which is a substantive departure from previous indirect and in vitro approaches.
- Trial name
- NCT03530111
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Polycystic Ovary Syndrome, Metabolic Diseases
Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)
The purpose of this study is to collect data to help understand why some women develop Polycystic Ovary Syndrome (PCOS) associated with decreased lower-body fat.
- Conditions
- Polycystic Ovary Syndrome, Metabolic Diseases, Overweight
- Trial name
- EIFFEL (NCT01745471)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity
STAGES Trial: Study of Adiposity, Growth and Endocrine Stages
The investigators propose to conduct a cross-sectional study of 60 participants who are 18-30 years of age to undergo research PET/CT.
- Trial name
- STAGES (NCT01460784)
- Where
- United States
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- University of Utah
Contraception, Body Weight
Emergency Contraception and Body Weight: Pilot Study
The purpose of this research study is to determine how body weight changes the drug level of an emergency contraceptive pill containing a hormone called levonorgestrel (LNG).
- Trial name
- NCT02408692
- Testing
- ECx1, ECx2
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Energy Expenditure, Obesity
BRown Fat Activity Measurement With Infrared imaginG tHermography andThermogenesis - the BRIGHT Study
The whole body calorimeter is sensitive enough to reliably measure cold-induced thermogenesis as a surrogate marker of brown adipose tissue (BAT) activation.
- Conditions
- Energy Expenditure, Obesity, Adipose Tissue, Brown
- Trial name
- BRIGHT (NCT02790255)
- Testing
- Cold air, Cold water
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity & Overweight
A Pharmacokinetic Study of VCT220 With Moderate Renal Impairment Patients
This Phase 1 study is designed to evaluate the pharmacokinetics and safety of a single oral dose of VCT220 (other name: CX11) in subjects with moderate renal impairment compared with age-, sex-, and body mass index (BMI)-matched…
- Trial name
- NCT07347808
- Testing
- VCT220
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vincentage Pharma Co., Ltd
PreDiabetes, Obesity
Effect of Mango Consumption on Individuals with Pre-diabetes
This study is designed to explore the effect of mango consumption on glycemic indices, cardiovascular health, and body composition in overweight and obese individuals with prediabetes.
- Trial name
- NCT05571800
- Testing
- Mango
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Florida State University
Adiposity, Metabolic Complication
Insight Into New Brown Adipose Tissue Activators.
The general purpose of the study was to provide new information about the role of macronutrients intake, metabolomics, proteomics and microRNA on BAT activation.
- Conditions
- Adiposity, Metabolic Complication, Metabolic Disturbance, Healthy
- Trial name
- NCT04787952
- Testing
- cold expossure
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Overweight , Obesity
A Study of Zovaglutide (ZT002 Injection) in Participants With Impaired Kidney Function and Healthy Participants
This study is a single-dose, open-label, parallel design phase I clinical study to evaluate the PK characteristics and safety of single subcutaneous injection of ZT002 Injection in participants with different degrees of renal…
- Trial name
- NCT07443059
- Testing
- Zovaglutide
- Where
- 3 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
Insulin Resistance, Obesity
Impact of Trans Fatty Acids From Natural and Industrial Origin in the Induction of Insulin Resistance Development
The investigators' project has as for principal objective to understand the impact of trans fatty acids from dairy products and industrial origin on the development of insulin resistance in obese woman.
- Trial name
- Trans-Insulin (NCT00617435)
- Testing
- vaccenic acid enriched diet, Elaidic acid enriched diet, control diet
- Where
- 2 sites in France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Obesity, Staphylococcal Skin Infections
A Study Evaluating the Pharmacokinetics of Ceftobiprole When Taken by Obese Patients
The primary objective of this study is to compare the pharmacokinetics (how drugs are absorbed in the body, how they are distributed within the body and how they are removed from the body over time) of ceftobiprole in morbidly…
- Conditions
- Obesity, Staphylococcal Skin Infections, Streptococcal Infections
- Trial name
- NCT01026558
- Testing
- Ceftobiprole
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Pain, Obesity, Childhood
Sumamos Excelencia Project: Implementation of Best Practices in Clinical Practice (Thrid Edition)
There is a gap between research and clinical practice, leading to variability in decision-making. Multifaceted implementation strategies are for improving implementation of best practices.
- Conditions
- Pain, Obesity, Childhood, Breast Feeding, Incontinence, Urinary
- Trial name
- SE24 (NCT06522529)
- Testing
- Multifaceted implementation strategy
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Instituto de Salud Carlos III
Obesity, Mycoses
Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations
This study will find how weight affects the dosing of a drug called anidulafungin. Currently, the amount of anidulafungin a patient receives is the same regardless of the patient's weight.
- Trial name
- NCT01307930
- Testing
- Anidulafungin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Obesity
Study Examining The Effect Of Renal Impairment On Safety, Toleration And How The Body Processes An Experimental Drug
CP-945,598 is eliminated following extensive metabolism. For some drugs, decreased renal (kidney) function can affect their elimination from the body via metabolism.
- Trial name
- NCT00472836
- Testing
- CP-945,598
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lipedema, Inflamation
Investigation of Systemic Inflammation Markers in Lipedema
The aim of this study is to evaluate systemic inflammation in individuals with lipedema using hematological and biochemical inflammation indices and to examine the relationship between these indices and clinical findings.
- Conditions
- Lipedema, Inflamation, Inflammation Biomarkers, Obesity & Overweight
- Trial name
- NCT07787234
- Testing
- Clinical parameters, Laboratory parameters
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Insulin Resistance, Obesity
Integrating the Genetic and Metabolic Faces of Obesity
The goal of this study is to determine why some obese individuals develop insulin resistance and others do not. We hypothesize that an impairment in differentiation of fat cells (adipocytes) is responsible for the development of…
- Conditions
- Insulin Resistance, Obesity, Metabolic Syndrome
- Trial name
- NCT00285844
- Testing
- weight loss, thiazolidinedione
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Stanford University