Clinical trials: Normal-weight Obesity
Obesity/Overweight
Study of Pharmacokinetics and Safety of GZR18 Injection in Subjects With Liver Insufficiency and Normal Liver Function
This study adopts a multicenter, single-dose, open-label, and parallel design, which is aimed at assessing the PK and safety profiles of GZR18 Injection in subjects with normal liver function and those with mild, moderate or…
- Trial name
- NCT07144098
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Gan & Lee Pharmaceuticals.
Rheumatoid Arthritis
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567.
A study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of multiple ascending doses of AZD9567.
- Trial name
- NCT02760316
- Testing
- AZD9567 10 mg, AZD9567 20 mg, AZD9567 40 mg
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity & Overweight, Normal Weight Adults
Long-term Iron Absorption and Loss in Women
Obese people typically have chronic low-grade inflammation. Based on short-term studies, this inflammation could affect the absorption, utilization, storage, and mobilization of iron, and individuals with inflammation might…
- Trial name
- NCT07855939
- Where
- Thailand
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Breast Cancer, Obesity
A Pilot Study of Docosahexaenoic Acid (DHA) in Obese Menopausal Women
This study aims to determine if a supplement of an omega-3-fatty acid (docosahexaenoic - DHA) lowers inflammation in human fat tissue thereby lowering estrogen production and the potential risk for breast cancer.
- Trial name
- NCT01127867
- Testing
- dietary intervention
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH)
How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver
Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
- Trial name
- AGL14 (NCT07133854)
- Testing
- Imaging PET/MRI, Stable isotope infusions, meal test
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Physiological Responses, Pilates Exercise
Effect of Muscle Strengthening Training with Pilates Reformer on Overweight/obese and Normal Body Weight Women (PRET)
This study investigates the physiological responses and the metabolic burden of a Pilates Reformer strength training session in physically inactive premenopausal women with a body mass index of 18-24.9 and 25.01-39.9.
- Conditions
- Physiological Responses, Pilates Exercise, Overweight and Obese Women, Energy Expenditure
- Trial name
- PRET (NCT06675162)
- Testing
- Pilates Reformer Training
- Where
- 2 sites in Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Drug Safety
Pharmacokinetics of Ceftaroline in Normal and Obese Subjects
The purpose of this study is to characterize plasma and urinary concentrations of ceftaroline following intravenous administration of a single dose of ceftaroline 600 mg in healthy subjects who are normal weight, overweight, and…
- Trial name
- NCT01648127
- Testing
- Ceftaroline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Keith A. Rodvold
Aging, Obesity
Expandability of Aging Adipose Tissue
The purpose of this pilot study is to determine whether adipose tissue loses some of its ability to expand in response to overfeeding in older compared to younger men.
- Trial name
- EAT (NCT02456870)
- Testing
- Overfeeding
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Stress
Brain-Gut Interactions in Overweight and Normal Weight Patients With Chronic Abdominal Pain
About 15 to 20 percent of individuals living in the United States have chronic abdominal pain, often of unknown origin, which is often difficult to diagnose and treat.
- Conditions
- Obesity, Stress, Irritable Bowel Syndrome, Women
- Trial name
- NCT00824941
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Infection Prevention
PROPHYLACTIC ANTIBIOTICS PRIOR TO CESAREAN SECTION IN OBESE WOMEN
Surgical site infections are common and a cause of major morbidity. They are also more common in obese women. Cesarean sections are the most common surgery performed in the United States, therefore pregnant women are being faced…
- Trial name
- NCT01810354
- Testing
- Cefazolin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Psoriasis, Obesity
Pilot Study Characterizing Adipose Tissue Leukocytes by Flow Cytometry/Microscopy in Lean, Obese and Psoriatic Subjects
Obesity is an insulin resistance-associated metabolic disorder which is a hallmark of and risk factor for type 2 diabetes and the metabolic syndrome, often linked to cardiovascular disease, certain cancers and inflammatory…
- Trial name
- NCT01856647
- Testing
- Adipose tissue biopsy (fat biopsy)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Overweight and Obesity
A Trial to Assess the Effect of Kidney Impairment on How AMG 133 is Absorbed, Broken Down, and Eliminated by the Body
The primary objective of this trial is to evaluate the pharmacokinetics of a single subcutaneous (SC) dose of AMG 133 in participants with various degrees of renal impairment compared to participants with normal renal function.
- Trial name
- NCT07429045
- Testing
- AMG 133
- Where
- 5 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Amgen
Heart Failure, Obesity
Fatty Acid Radiotracer Comparison Study in Heart Failure Patients
A single center, open-label baseline controlled imaging study to designed to assess whether Positron Emission Tomography (PET) measurements of myocardial Fatty Acid (FA) metabolism performed with [18F]FluorbetaOx correlates with…
- Conditions
- Heart Failure, Obesity, Type 2 Diabetes Mellitus, Health Normal Volunteer Subjects
- Trial name
- NCT01648296
- Testing
- [18F]FluorbetaOx
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Sedentary Behavior, Adipose Tissue
Participatory Intervention to Improve Nutrition and Physical Activity in Schoolchildren From Acatlán de Juárez, Jalisco
This is a community project carried out jointly by the Technological Institute of Higher Studies of the West (ITESO), the University Center of Tonalá of the University of Guadalajara (CUTonalá) and the University Center of Health…
- Conditions
- Sedentary Behavior, Adipose Tissue, Child Obesity
- Trial name
- Acatlan (NCT04679246)
- Testing
- Participatory intervention
- Where
- Mexico
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Iberoamerican Institute of Sports Science and Human Movement
Diabetes, Obesity
Multi-Tracer PET Quantitation of Insulin Action in Muscle (Phase 1, Phase 2, Phase 3, Phase 4)
The purpose of this research is to develop a new method to study insulin action using positron emission tomography (PET). Insulin is the hormone made by your body to control the blood sugar level.
- Trial name
- NCT00222885
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Rheumatoid Arthritis, Psoriatic Arthritis
GOTHA - The Early Arthritis and Psoriasis Study of Region Västra Götaland, Sweden
GÖTHA- The early arthritis and psoriasis study of Region Västra Götaland, Sweden - is a longitudinal observational study, which will prospectively and in parallel follow patients with newly diagnosed rheumatoid arthritis (RA…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Arthritis, Psoriasis
- Trial name
- GOTHA (NCT04190758)
- Testing
- Care as usual
- Where
- Sweden
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Atopic Dermatitis, Food Allergy in Children
Preventing Atopic Dermatitis and ALLergies in Children
The primary objective is of the PreventADALL study is to test if primary prevention of allergic diseases is possible by simple and low cost strategies, and secondary to asses the impact of xenobiotic exposure and microbiota in…
- Conditions
- Atopic Dermatitis, Food Allergy in Children, Asthma, Rhinitis, Allergic
- Trial name
- PreventADALL (NCT02449850)
- Testing
- Food intervention, Skin care
- Where
- Norway
- Volunteers
- 2,701 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Obesity
Mirabegron and Brown Adipose Tissue
Obesity and type 2 diabetes (T2D) are emerging problems worldwide. In particular South Asian individuals (representing 20% of the world population) have an increased risk of obesity and related disorders.
- Trial name
- Mirab (NCT03012113)
- Testing
- Mirabegron, Short term mild cooling
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Adiposity
Ectopic Adipose Tissue, Exercise Training and IL-6
Aim: Exercise training improves the risk of cardiometabolic diseases; yet the underlying mechanisms are unclear. Exercise induces release of IL-6 from skeletal muscle.
- Trial name
- NCT02901496
- Testing
- Endurance Exercise Training, Resistance Exercise Training, No Exercise
- Where
- Denmark
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet