Clinical trials: Normal-weight Obesity
Adipose Tissue
Effect of Obesity on Extracellular Matrix Composition
The experiment is a simple cross-sectional study with three groups (n=10) in each group, young and old healthy men and obese young men. The study will investigate the composition of the adipose tissue extra cellular matrix.
- Trial name
- EOBECM (NCT06304506)
- Testing
- Cross sectional study
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity & Overweight
A Pharmacokinetic Study of VCT220 With Moderate Renal Impairment Patients
This Phase 1 study is designed to evaluate the pharmacokinetics and safety of a single oral dose of VCT220 (other name: CX11) in subjects with moderate renal impairment compared with age-, sex-, and body mass index (BMI)-matched…
- Trial name
- NCT07347808
- Testing
- VCT220
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vincentage Pharma Co., Ltd
Breast Cancer, Obesity
Vitamin D, Diet and Activity Study
Experimental and human data suggests that vitamin D could protect against breast cancer. Overweight/obese individuals are at increased risk of low vitamin D levels.
- Conditions
- Breast Cancer, Obesity, Hypovitaminosis D
- Trial name
- ViDA (NCT01240213)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Cancer, Breast, Obesity, Abdominal
SCOPE-Chinese Women Study
This project examines the feasibility of a smartphone-based intervention to reduce obesity and breast cancer risk among Chinese women in China.
- Trial name
- SCOPE (NCT04326660)
- Testing
- SCOPE-Chinese Women
- Where
- 2 sites in United States, China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity
Fasting Mimicking Diet and Beige/Brown Adipose Tissue in Humans
Obesity today has become one of the main public health concerns. As a consequence, different strategies have arisen to fight weight gain.
- Trial name
- NCT04385615
- Testing
- Fasting Mimicking Diet
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Obesity, Abdominal
Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue
A fully functional brown fat helps maintain a healthy weight and decreases the risk of metabolic diseases such as type II diabetes (T2DM).
- Trial name
- BATNAD (NCT06627868)
- Testing
- NAD+ precursor
- Where
- Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Turku
Diabetes Risk
Using Salsalate to Target Adipocyte Macrophage Infiltration
Background: The prevalence of obesity has increased throughout the last three decades due to genetic, metabolic, behavioral, and environmental factors.
- Trial name
- TAMI (NCT02130804)
- Testing
- Salsalate (4 g/day)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Sleep Disorder, Body Fat Distribution
Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea
Comparison of the prevalence of obstructive sleep apnea (OSA), measured by polysomnography in normal weight patients with central obesity by body mass index (BMI) and waist hip ratio (WHR), with normal weight patients without…
- Trial name
- NCT04061226
- Testing
- Overnight polysomnography
- Where
- Czechia
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Obesity, Insulin Resistance
Glucose Uptake in Metabolic Tissues After Bariatric Surgery
The goal of this study is to provide a comprehensive evaluation of whole-body and tissue-specific glucose metabolism after consuming a mixed meal in lean people and people with obesity, before and after 20-35% weight loss induced…
- Trial name
- GU (NCT03563885)
- Testing
- bariatric surgery
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy, Obesity
Mitochondrial Function in Circulating Cells and Muscle Tissue
The main goal of this project is to determine whether mitochondrial function in circulating cells is related to that measured in the muscle fibers of the same subjects.
- Conditions
- Healthy, Obesity, Insulin Sensitivity, Women
- Trial name
- MitoWomen (NCT02700698)
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Breast Cancer
Using Technology to Improve Physical Activity Levels Among Postmenopausal Women (The Active & Aware Study)
Women who are overweight or do not exercise are at higher risk for breast cancer after menopause. This study will test a new electronic device that measures the body's movement and works alongside a website to help women increase…
- Trial name
- NCT01837147
- Testing
- Technology-Based Physical Activity Promotion, Pedometer Intervention
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cardiovascular Risk Factor, Cardiovascular Diseases
Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults
The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Diabetes, Physical Activity
- Trial name
- NCT03898206
- Testing
- Breaking up sitting with walking breaks (INT-SIT), Prolonged sitting (SIT)
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Bedfordshire
Insulin Resistance
Vitamin D Supplementation and Glycemic Outcomes
The investigators examined the effect of vitamin D supplementation on glucose homeostasis and metabolic markers in healthy normal weight and overweight young subjects and healthy normal-weight and overweight elderly subjects…
- Trial name
- NCT02942732
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Université d'Auvergne
Nutrition, Mastication
Mastication and Energy Expenditure in Normal Weight and Obese People
The objective of the study is to analyze the specific role of physical properties of food and mastication in the cephalic phase reflex of thermogenesis, and the involvement of the autonomic nervous system in the implementation of…
- Trial name
- MASTICAL (NCT04050930)
- Testing
- Mastication
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obesity, Exercise
Exercise Training and Insulin Sensitivity
Regular exercise participation is known to reduce cardiometabolic disease risk but the impact that exercise training has on adipose tissue (AT) metabolism is poorly understood, particularly in humans.
- Trial name
- NCT05930834
- Testing
- exercise
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Triple Negative Breast Cancer
Epigenetics of TNBC in Overweight and Obese Hispanic & Non-Hispanic White Women
A key tenet of this project is that of reaching translational human diagnosis and biomarker end points. To lay a foundation and make progress towards these translational goals, investigators will address the following specific…
- Trial name
- NCT04291950
- Testing
- Needle core biopsy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Pregnancy; Nutritional Diseases
Growth and Adiposity in Newborns: The Influence of Prenatal Docosahexaenoic Acid (DHA) Supplementation
The purpose of this study is to learn if participants in the ADORE study (NCT02626299), who took a DHA supplement during pregnancy, see favorable body fat in their infants from birth to 24 months, and if excessive or appropriate…
- Trial name
- ADORE-GAINS (NCT03310983)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Adiposity
Comparing the Effects of Exercise on the Structure and Function of Fat Tissue
Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.
- Trial name
- CAT (NCT05328570)
- Testing
- Oral Glucose Tolerance Test
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity
Mechanism of Growth Hormone Effects on Adipose Tissue
Growth hormone treatment in humans has been shown to decrease body fat. This study aims to determine what adipose tissue depots are affected by GH and what is the mechanism.
- Trial name
- GH (NCT00453557)
- Testing
- rhGH
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Healthy
Overnight Weight Loss and Sleep Structure
The objectives of the present study are: 1. to evaluate if overnight weight loss is dependent on sleep structure assessed by polysomnography; 2. to compare weight loss rate during sleep and awake rest; 3.
- Trial name
- weightsleep (NCT00915642)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia