Clinical trials: Normotensive
Blood Pressure
The Dose Response Effect of Isometric Handgrip Training Frequency on Blood Pressure in Normotensive Individuals
It is estimated by WHO (2021) that 1.4 billion individuals across the globe have high blood pressure with only 14% of people managing these elevated levels.
- Trial name
- NCT06329804
- Testing
- Isometric Handgrip Exercise Training (IHGT)
- Where
- 2 sites in Taiwan, United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Swansea University
Healthy Normotensive Volunteers
Chronopharmacology of Valsartan in Normotensive Subjects
The choice of drug administration time may affect the pharmacokinetics and/or drug response, and knowledge of any such circadian rhythm-dependent effects may help to reduce side effects or to enhance efficacy.
- Trial name
- NCT02631031
- Testing
- Valsartan
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Biopsy-confirmed IgA Nephropathy, Proteinuria Less Than 0.5 g Per Day
Treatment of Early Immunoglobulin A Nephropathy by Angiotensin Converting Enzyme Inhibitor - A Randomized Controlled Trial
Immunoglobulin A (IgA) nephropathy is the most common type of primary glomerulonephritis in the world. The treatment of IgA nephropathy with normal renal function and minimal proteinuria is unknown.
- Conditions
- Biopsy-confirmed IgA Nephropathy, Proteinuria Less Than 0.5 g Per Day, Normal Blood Pressure, Serum Creatinine Below 120 Umol/l
- Trial name
- NCT01225445
- Testing
- Ramipril
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Salt-sensitive Hypertension
Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet
The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention.
- Trial name
- Salt (NCT01324245)
- Testing
- Fenoldopam
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Low Blood Pressure, Normal Blood Pressure
Clinical Trial of H2-BP Electronic Sphygmomanometer
The study compares H2-BP, a wristband blood pressure monitor, with an auscultatory sphygmomanometer. Both devices are used on the same arm.
- Conditions
- Low Blood Pressure, Normal Blood Pressure, Prehypertension, Hypertension
- Trial name
- NCT06491433
- Testing
- H2-BP
- Where
- South Korea
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Normotensive, Sleep Apnea, Obstructive
Normotensive OSA Patients With Dipper Circadian Blood Pressure Pattern
The principal objective is to evaluate the effect of CPAP treatment on blood pressure (BP) in normotensive patients with dipper circadian pattern with sleep apnea-hypopnea syndrome (SAHS).
- Trial name
- NCT03948373
- Testing
- CPAP treatment
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Sepsis, Vasoplegia
Occult Vasoplegia in Normotensive Sepsis: Early Prediction With Diastolic Index and Lactate
The goal of this observational study is to learn if the Diastolic Shock Index (DSI) and initial lactate can predict occult vasoplegia in adults with normotensive sepsis.
- Conditions
- Sepsis, Vasoplegia, Septic Shock
- Trial name
- DIAL-SEPSIS (NCT07658014)
- Where
- Mexico
- Volunteers
- 526 people
- Sponsor
- Hospital H+ Queretaro
Healthy
Effects of Sodium Intake on (PK/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker
The impact of sodium intake on plasma drug concentrations has previously been reported in the literature for verapamil and quinidine but, to the investigators' knowledge, never with renin-angiotensin system blockers such as AT1R…
- Trial name
- NCT00310778
- Testing
- high sodium diet, low sodium diet, ramipril 10 mg
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy, Pregnancy - Prenatal Testing
Effect of Isometric Handgrip Exercise on Blood Pressure in Pregnant Women
Hypertension during pregnancy is a major public health concern, increasing the risk of cardiovascular complications for both the mother and the fetus.
- Conditions
- Pregnancy, Pregnancy - Prenatal Testing, Hypertension (HTN)
- Trial name
- GRIP4HEALTH (NCT07607795)
- Testing
- Isometric Handgrip Exercise, Control Rest
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Poitiers
Hypertension
Transcutaneous Electrical Acupoint Stimulation on Blood Pressure
This study will be conducted in patients with high-normal blood pressure and grade 1 hypertension and will be divided into two phases.
- Trial name
- NCT06537167
- Testing
- Transcutaneous electrical acupoint stimulation
- Volunteers
- 120 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Healthy Normotensive Participants
Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide (Double Doses)
This study was conducted to compare the rate and extent of absorption of valsartan and hydrochlorothiazide. To maximize the possibility of finding drug-drug interactions, the dose of valsartan and hydrochlorothiazide was doubled…
- Trial name
- PKVH PART II (NCT01767298)
- Testing
- Valsartan/Hydrochlorothiazide, Valsartan, Hydrochlorothiazide
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Diabetes Mellitus, Type 2
Ambulatory Blood Pressure Reduction After Rosiglitazone Treatment In Normotensive Type 2 Diabetic Patients
The purpose of this study was to determine the effects of rosiglitazone in normotensive type 2 diabetic patients with regard to its blood-pressure-reducing effects.
- Trial name
- NCT00290394
- Testing
- rosiglitazone(drug), blood pressure lowering effect
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Baskent University
Healthy
Drug Interaction Between Irbesartan and Hydrochlorothiazide
This study was conducted to investigate any potential reaction between irbesartan and hydrochlorothiazide.
- Trial name
- NCT01858610
- Testing
- Irbeasartan/hydrochlorothiazide, Irbesartan, Hydrochlorothiazide
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Damanhour University
Tocolysis With Nifedipine
Changes in Central Arterial Pressure of Normotensive Women Taking Nifedipine for Tocolysis
To determine the central blood pressure changes in normotensive women who are receiving nifedipine for uterine contraction suppression
- Trial name
- NCT02902354
- Testing
- Nifedipine for tocolysis
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Louis University
Postmenopausal, Hypertension
Cardiovascular Adaptations to Resistance Exercise: Effect of Set Configuration on Postmenopausal Women
The main purpose of this project is to analyze the effect of set configuration of resistance exercise on cardiovascular responses and adaptations of postmenopausal women.
- Trial name
- CARE (NCT05544357)
- Testing
- Short set configuration resistance training, Long set configuration resistance training
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Safety Issues, Tolerance
Safety and Tolerability of 2 Dietary Supplement Beverages Designed to Maintain Healthy Blood Pressure.
This study is designed to evaluate the safety and tolerability of two distinct dietary supplement beverage formulations designed to maintain normal blood pressure.
- Trial name
- NCT06442293
- Testing
- Treatment 1, Treatment 2
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- USANA Health Sciences
Pre-hypertension
Different Dosages of Bioactive Wheat Peptides and Blood Pressure Level and CVD Risk Biomarkers in Healthy Subjects
In this study we will assess the effects of bioactive peptide rich wheat products on blood pressure and estimated cardiovascular disease risk.
- Trial name
- NCT02197910
- Testing
- Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence Low->High), Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence High->Low)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bologna
High-normal Blood Pressure
Study of Antihypertensive Treatment and Cardiovascular Risk in Chinese Prehypertensive Population
I. Research Objectives Primary Objectives: To evaluate the effect of low-dose antihypertensive therapy on the incidence of new-onset hypertension and new-onset diabetes in individuals with high-normal blood pressure and…
- Trial name
- NCT07652567
- Testing
- Telmisartan, Indapamide
- Where
- China
- Volunteers
- 690 people
- Sponsor
- Qilu Hospital of Shandong University
Autosomal Dominant Polycystic Kidney Disease
Assessment of Longitudinal Changes in Endothelial Function and Oxidative Stress in Normotensive Patients With ADPKD
The purpose of this study is to determine whether patients with autosomal dominant polycystic kidney disease (ADPKD) present with abnormal endothelial function, increased levels of NOX4 activity and mitochondrial abnormalities…
- Trial name
- NCT03493802
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obstructive Sleep Apnea
Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients
Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension.
- Trial name
- OSA-NORMO (NCT00741520)
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo