Clinical trials: Normoxia
High Altitude Pulmonary Edema
Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction
It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia.
- Trial name
- NCT00559442
- Testing
- Altitude Exposure:
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Compare Preoxygenation Methods in Bariatric Patients
Preoxygenation With High Flow Nasal Cannula Prolongs Normoxia Time During Induction of Anaesthesia of Bariatric Patients and is Superior to Conventional Preoxygenation With Face Mask.
To compare preoxygenation for induction of general anaesthesia with High Flow Nasal Cannula vs preoxygenation with face mask in patients undergoing bariatric surgery.
- Trial name
- NCT04965610
- Testing
- Preoxygenation with High Flow Nasal Cannula, Preoxygenation via face mask
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Staedtisches Klinikum Karlsruhe
Cardiovascular Diseases, Vasodilation
The Nitrite and Coronary Flow Study
This study is a pharmacodynamic proof of concept study investigating the physiological effects of systemic infusion of nitrite on coronary blood flow using MRI.
- Conditions
- Cardiovascular Diseases, Vasodilation, Hypoxia
- Trial name
- NCT04354051
- Testing
- Sodium Nitrite
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Hypoxia, Altitude, Blood Flow Restriction
Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions.
- Conditions
- Hypoxia, Altitude, Blood Flow Restriction, Resistance Training
- Trial name
- NCT06171841
- Testing
- low-intensity resistance training, high-intensity resistance training, low-intensity resistance training combined with blood flow restriction
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Normoxia, Intermittent Moderate Hypoxia
Brain Connectivity and Corticospinal Excitability in Response to Moderate Hypoxia
Hypoxia, defined as a reduction in the availability of oxygen, induces significant physiological adaptations. While the deleterious effects of severe and chronic hypoxia are well documented, several studies indicate that moderate…
- Conditions
- Normoxia, Intermittent Moderate Hypoxia, Continuous Moderate Hypoxia
- Trial name
- NEUROXIE (NCT07516028)
- Testing
- Moderate hypoxia, Normoxia, Transcranial Magnetic Stimulation
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universite du Littoral Cote d'Opale
Hypobaric Hypoxia, Hypobaric Normoxia
Cognition at Altitude in HEMS - Part II
The aim of the current study is to evaluate under blinded conditions, both in a simulated environment and during helicopter flight, the effect of a rapid (within 20 minutes) exposure to altitude (4000 m asl) on physiological…
- Conditions
- Hypobaric Hypoxia, Hypobaric Normoxia, Cognitive Performance, Emergency Medicine
- Trial name
- HEMS II (NCT05073406)
- Testing
- Altitude exposure in hypobaric normoxic condition, Altitude exposure in hypobaric hypoxic condition
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Healthy Men and Women
Metabolic Dynamics During Physical Activity
The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on…
- Trial name
- NCT03485716
- Testing
- running on a treadmill under normoxia or hypoxia
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Intermittent Hypoxia, Normoxia
Intermittent Hypoxia and Balance Control
This study aims to determine the effect of acute mild intermittent hypoxia on ankle plantarflexor muscle output during balance regulation and walking in younger and older adults.
- Trial name
- NCT05463042
- Testing
- Intermittent Hypoxia
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Hypoxia, Normoxia
Effects of Oxygen Status on Endotoxemia Induced Inflammation and Hypoxia Inducible Factor-1α
Oxygen is a widely available gas that is cheap, easy to get and extensively used in medicine. From animal studies it has become apparent that increasing or lowering the degree of oxygen in the blood, the inflammatory response can…
- Conditions
- Hypoxia, Normoxia, Hyperoxia
- Trial name
- NCT01978158
- Testing
- Lipopolysaccharide
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Normoxia, Hypoxia
Intrinsic Periodic Pattern of Breathing
We made a fortuitous observation of periodic breathing in a healthy subject coming to our outpatient mountain medicine consultation at Avicenne hospital in Bobigny (France).
- Conditions
- Normoxia, Hypoxia, Hyperoxia, Hypercapnia
- Trial name
- PERHYP1 (NCT02201875)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Association pour la Recherche en Physiologie de l'Environnement
Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation
The Role of S-nitrosohemoglobin in Regulating Systemic Blood Flow During Hypoxia and Normoxia
Nitric oxide is believed to contribute to regulation of blood flow by its selective binding to circulating hemoglobin (forming S-nitrosohemoglobin, SNO-Hb) and release in a PO2-dependent manner.
- Trial name
- NCT01905696
- Testing
- Oral N-acetylcysteine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Low Level Laser Therapy, Photobiomodulation
Influence of PBM on Anaerobic Capacity Under Normoxia and Hypoxia
The photobiomodulation (PBM) shows positive results in muscle performance, fatigue reduction, management of blood lactate production, analgesia and in the increase of VO2 maximal, favoring the increase of ATP production and thus…
- Conditions
- Low Level Laser Therapy, Photobiomodulation, Performance, Sport
- Trial name
- NCT05595564
- Testing
- Photobiomodulation therapy
- Where
- Brazil
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
High-intensity Strenght Training in Normoxia (H-N), Low-intensity Strenght Training in Normoxia (L-N)
Normobaric Hypoxia as a Strength Training Intensity Amplifier in Ice Hockey Players: Effects on Anaerobic Performance and Muscle Contraction Properties
The goal of this research study is to investigate the effects of resistance training performed under normobaric hypoxia (simulated altitude conditions) on anaerobic performance, lactate clearance, and muscle contractility in…
- Conditions
- High-intensity Strenght Training in Normoxia (H-N), Low-intensity Strenght Training in Normoxia (L-N), High-intensity Strenght Training in Normobaric Hypoxia (H-H), Low-intensity Strenght Training in Normobaric Hypoxia (L-H)
- Trial name
- NCT06930027
- Testing
- Resistance Training (High-Intensity), Resistance Training (Low-Intensity), Normobaric Hypoxia
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Amyotrophic Lateral Sclerosis (ALS), Neuromuscular Diseases
Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
This project seeks to investigate the effects of a single acute intermittent hypoxia (AIH) session on respiratory and non-respiratory motor function and EMG (electromyography) activity on patients with ALS (amyotrophic lateral…
- Trial name
- AIH-ALS (NCT03645031)
- Testing
- Acute Intermittent Hypoxia
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hypoxia, Brain
Supplementation of 500mg Trans-resveratrol Within Hypoxic and Normoxic Conditions, in Healthy Humans.
Objectives: Resveratrol, a non-flavonoid polyphenol, has been found to consistently modulate cerebral blood flow (CBF) following oral supplementation.
- Trial name
- NCT03100019
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healthy, Normoxia
Measurement of Retinal Blood Flow, Retinal Oxygenation and Retinal Oxygen Extraction in Healthy Subjects During Normoxia and Systemic Hyperoxia
The inner retina is crucially dependent on an adequate retinal blood supply. When the retina becomes ischemic and hypoxic this results in severe vision loss due to retinal neovascularization.
- Conditions
- Healthy, Normoxia, Systemic Hypoxia
- Trial name
- NCT00914407
- Testing
- Oxygen
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy Volunteers
The Haem and Nitrite Study - The Effects of Haemoglobin NO-blockade on Nitrite-induced Forearm Vessel Dilatation
The study is a pharmacodynamic random order cross-over trial investigating the physiological effects of intra-arterial infusion of nitrite following a haemolysed autologous blood transfusion.
- Trial name
- NCT03077763
- Testing
- Sodium Nitrite
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Hypoxia, Repeated Sprints
Effects of Hypoxic Repeated Sprint Training on Performance in Normoxia in Male and Female Athletes
With the increased participation of women in sports, it is essential to develop gender-tailored training strategies for improving exercise performance.
- Trial name
- RSHwomen (NCT05439239)
- Testing
- Repeated sprint training
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Normobaric Hypoxia, Hypoventilation
Influence of Hypoxic, Normobaric and Hypobaric Training on the Immunometabolism of Post-covid-19 Athletes
COVID-19 has significantly impacted sports globally, with event postponements, training disruptions, and wide-ranging concerns. SARS-CoV-2 infection can result in hyperinflammation and cardiopulmonary changes, with hypoxia as an…
- Conditions
- Normobaric Hypoxia, Hypoventilation, Normoxia
- Trial name
- NCT06128941
- Testing
- Repeated sprint
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana