Clinical trials: Nulliparous, open to volunteers
Prolonged Labor, Labor Dystocia
Efficacy of Bicarbonate on the Risk of Assisted Delivery in Nulliparous Women With Prolonged Labour
The goal of this clinical trial is to learn if oral bicarbonate can treat prolonged labour in nulliparous women with prolonged labour.
- Trial name
- ProLabour (NCT07321379)
- Testing
- Sodium bicarbonate
- Where
- 3 sites in Denmark
- Volunteers
- 1,520 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Cardiometabolic Health, Pregnancy Related
Cardiometabolic Health in First Time Pregnancy
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth…
- Conditions
- Cardiometabolic Health, Pregnancy Related, Diabetes, Placental; Syndrome, Dysfunction
- Trial name
- POPPY (NCT05856318)
- Where
- 7 sites in United Kingdom
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Urinary Incontinence, Anal Incontinence
Pelvic Floor Muscle Training During Pregnancy
The project seeks to investigate effectiveness of PFMT during pregnancy.
- Conditions
- Urinary Incontinence, Anal Incontinence, Pelvic Organ Prolapse, Sexual Dysfunction
- Trial name
- NCT07104292
- Testing
- PFMT, Standard care
- Where
- Denmark
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Nulliparous Women Who Scheduled for Labor Induction, Pregnancy
Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
The purpose of this study is to compare the effectiveness of sequential versus combined multimodal cervical ripening strategies to achieve vaginal delivery within 24 hours among nulliparous patients with singleton, vertex…
- Trial name
- RAPID-DS (NCT07717502)
- Testing
- Sequential Cervical Ripening, Inpatient Combined Cervical Ripening
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Ochsner Health System
Pregnancy
The Effect of a Mindfulness-Based Stress Reduction Program Applied to Nulliparous Pregnant Women
Mindfulness-based stress reduction programs are among the effective methods that can contribute to managing anxiety during pregnancy, strengthening mother-fetus interaction, and supporting psychological well-being.
- Trial name
- NCT07510555
- Testing
- Intervention group (Mindfulness-Based Stress Reduction Program), Control group
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amasya University
Neurodevelopmental Disorders
5-Year Follow-up of Children and Mother After Expectant Management Versus Induction of Labor in Low-risk Nulliparous Women at 39 Weeks of Gestation
In France, the rate of labor induction has markedly increased in recent years, partly following the ARRIVE trial suggesting short-term benefits of elective induction at 39 weeks in low-risk nulliparous women.
- Trial name
- FAMILY-FA (NCT07330336)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 4,200 people
- Sponsor
- University Hospital, Bordeaux
Preeclampsia
Biological Changes Associated With High Risk of Preeclampsia in Nulliparous Women
Primary outcome 1. to identify biological changes in nulliparous women at high risk for preeclampsia defined by combined screening by Fetal Medicine Foundation (FMF) 2.
- Trial name
- PRERISK (NCT06200571)
- Where
- 2 sites in Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Nulliparous Patient With Unfavourable Cervix, Undergoing Labor Induction at Term ≥ 39SA
Prediction of Labor Induction Outcome in Nulliparous Women
Labor induction rates are increasing worldwide, yet nulliparous patients remain at high risk of failed induction and intrapartum cesarean delivery as well as prolonged labor which are associated with increased maternal morbidity…
- Trial name
- PREDISS (NCT07637318)
- Testing
- Vaginal sample
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ART, Pre-Eclampsia
Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology
This study seeks to validate the hypothesis that nulliparous pregnant women after Assisted Reproductive Technology (ART) are at high risk of preeclampsia and perinatal complications and represent a subgroup for which aspirin…
- Trial name
- APPART (NCT05625724)
- Testing
- Aspirin
- Where
- 21 sites in France
- Volunteers
- 1,164 people
- Sponsor
- University Hospital, Toulouse
Pregnancy
The Effect of Ultrasound Visual Feedback on Birth Outcomes in Nulliparous Women With Levator Ani Muscle Co-activation at Term Pregnancy
The study aims to evaluate the effect of ultrasound-based visual feedback training of the pelvic floor muscles in nulliparous women at term pregnancy who present co-activation of the levator ani muscle, on the duration of the…
- Trial name
- CoA_2025 (NCT07675642)
- Testing
- Ultrasound Visual Feedback Training
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Uterine Anteflexion
Changes in the Angle of Uterine Flexion as the Bladder Fills
The goal of this clinical trial is to evaluate how bladder filling affects the uterine flexion angle in adult nulliparous women with a uterine flexion angle <90° when the bladder is empty.
- Trial name
- FLEXIMIX3 (NCT07803627)
- Testing
- Ultrasonography, Pelvic
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Cesarean Section
Labor Induction in Low-risk Nulliparous Women at 39 Weeks of Gestation to Reduce Cesarean: A Randomized Trial of Induction Versus Expectant Management in France (FRENCH-ARRIVE)
The recent ARRIVE trial conducted in United States of America in 2014-2017 demonstrates that elective induction of labor at 39 weeks for nulliparous women did result in a significantly lower frequency of cesarean delivery with no…
- Trial name
- FRENCH-ARRIVE (NCT04799912)
- Testing
- Elective labor induction
- Where
- France
- Volunteers
- 4,200 people
- Sponsor
- University Hospital, Bordeaux
Induction of Labor Affected Fetus / Newborn
Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous
The goal of this randomized controlled trial is to examine the efficacy of combining castor oil ingestion with extra-amniotic single balloon catheter for cervical ripening on time from induction to delivery in nulliparous women.
- Trial name
- NCT06325007
- Testing
- Induction of labor
- Where
- 2 sites in Israel
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Intrauterine Device
MUSIC Prior to a T380A Intrauterine Device Insertion in Nulliparous Women.
The aim is to evaluate the role of music in reducing pain and anxiety during copper IUD insertion in nulliparous women
- Trial name
- NCT06783920
- Testing
- music, no music
- Volunteers
- 100 people
- Sponsor
- Cairo University
Perinatal Decision Making
Improving Safety, Patient Experience and Equity Through Shared Decision-making Huddles in Labor
To evaluate the effectiveness of an existing quality improvement (QI) training program known as TeamBirth, using a randomized stepped-wedge hybrid type II study design, to (a) decrease nulliparous term singleton vertex (NTSV)…
- Trial name
- I'M SPEAKING (NCT06828406)
- Testing
- TeamBirth
- Where
- 22 sites in United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Fear of Childbirth Pregnancy Childbirth Education Birth Preferences
Effect of Theory-Based Childbirth Preparation Education in Nulliparous Pregnant Women
This randomized controlled trial aims to evaluate the effect of a Health Belief Model- and Self-Efficacy Theory-based childbirth preparation education on fear of childbirth, childbirth self-efficacy, birth preferences, and…
- Trial name
- HBM-SE Birth (NCT07692724)
- Testing
- Health Belief Model and Self-Efficacy Theory-Based Childbirth Preparation Education, Routine Antenatal Care
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sibel Akgül Kartal
Breakthrough Pain
PIEB Compared With CEI on Breakthrough Pain in Nulliparous Women
The goal of this randomized controlled trial is to examine the impact of programmed intermittent bolus epidural analgesia technique on the incidence of breakthrough pain during labor in nulliparous women compared to continuous…
- Trial name
- NCT06494280
- Testing
- programmed intermittent Bolus epidural analgesia, continuous epidural infusion
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
High-risk Nulliparous Pregnancy, Patients Scheduled for Cesarean Section, Surgical Fear, Preoperative Anxiety, and Cortisol Level
The Effect of Mandala Art Therapy on Surgical Fear and the Stress Hormone (Cortisol) in High-risk Pregnant Women Before Cesarean Section.
This randomized controlled study aims to evaluate the effect of mandala art therapy applied before cesarean section on surgical fear and cortisol levels in high-risk pregnant women.
- Trial name
- NCT07691320
- Testing
- Mandala Art Therapy
- Volunteers
- 142 people
- Sponsor
- Inonu University
Delivery Complication, Labor Long
Effect of Oral Carbohydrate Intake > 44kCal Per Hour During Labour on the Rate of Instrumental Vaginal Delivery
Carbohydrate intake during physical exercise improves muscle performance and decreases fatigue. We hypothesized that carbohydrate intake during labor which is a period of significant physical activity can decrease the…
- Conditions
- Delivery Complication, Labor Long, Pregnancy Related
- Trial name
- soliso-2 (NCT05080309)
- Testing
- carbohydrate oral intake, free water only
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Urinary Incontinence
Effects of a Multimodal and Multidimensional Intervention on Urinary Incontinence in Young Nulliparous Female Athletes.
A prevalence of urinary incontinence ranging from 5.7% to 80% has been observed in young nulliparous athletes during their activity. The usual recommendations for managing adult women do not seem to be transferable.
- Trial name
- PELVICATHLE (NCT07644273)
- Testing
- Combined pelvic health education and lumbar-pelvic-abdominal stability strengthening programme., Usual activities
- Where
- France
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne