Clinical trials: Nut Hypersensitivities
Peanut Allergy
Phase I Trial to Evaluate VLP Peanut in Healthy and Peanut Allergic Subjects
This phase I clinical trial is designed to evaluate the safety and tolerability of VLP Peanut in healthy subjects and in subjects with peanut allergy (PA).
- Trial name
- PROTECT (NCT05476497)
- Testing
- VLP Peanut
- Where
- 10 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Allergy Therapeutics
Allergy;Food
Biomarkers in Food Allergy Diagnosis
Food allergy is a global burden, affecting patients, society as a whole and the economy. For most common food allergies, patients synthesize specific IgE-antibodies against harmless food proteins.
- Trial name
- APSIS (NCT04604912)
- Where
- 2 sites in Luxembourg
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Peanut Allergies
Flow CAST® Peanut Trial
This will be a multi-center, prospective evaluation, conducted at a minimum of four (4) U.S. sites. Sites will enroll peanut allergic subjects, subjects with allergies other than peanut and apparently healthy non-atopic control…
- Trial name
- NCT07775430
- Testing
- Basophil activation test
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Bühlmann Laboratories AG
Peanut Allergies, Tree Nut Allergies
Blood Samples for the Study of Peanut, Tree Nut and Other Food Allergies
Food allergies are now a major problem. These experiments involve getting blood from people with food allergies and from people without food allergies.
- Conditions
- Peanut Allergies, Tree Nut Allergies, Other Food Allergies
- Trial name
- NCT02192866
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Tree Nut Allergy, Food Allergy
TRADE Trial - Tree Nut Immunotherapy Route Development and Evaluation
Tree nut immunotherapy Route Assessment and DEvelopment (TRADE) is a randomized controlled trial that evaluates the efficacy and safety of sublingual immunotherapy and lower, more tolerable, doses of oral immunotherapy than…
- Trial name
- TRADE (NCT05521711)
- Testing
- Food
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Food Hypersensitivity, Hypersensitivity
Peanut Allergy Vaccine Study in Healthy and Peanut-allergic Adults
The purpose of this study is to evaluate the safety and side effects of a study product that contains recombinant modified peanut proteins (EMP-123) in healthy and peanut-allergic participants. This is a first in human study.
- Conditions
- Food Hypersensitivity, Hypersensitivity, Immediate Hypersensitivity, Peanut Hypersensitivity
- Trial name
- NCT00850668
- Testing
- E. Coli-Encapsulated, Recombinant Modified Peanut Proteins Ara h 1, Ara h 2, and Ara h 3
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Allertein Therapeutics, LLC
Allergic Rhinitis, Peanut Allergies
The Role of Filaggrin Mutations and Sensitization Pathways in Allergic Rhinitis and Peanut Allergy
Caucasian male and female participants age 18 years of age and older will be enrolled in this study if they have known birch or peanut allergies or known to be non-atopic.
- Trial name
- NCT02745418
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr. Anne Ellis
Child Allergy, Food Allergy
Impact of an Educational Tool on Quality of Life and Anxiety in Parents of Children With Nut Allergy
The number of young children with food allergy, in particular with nut allergy, is increasing worldwide. A diagnosis of nut allergy can cause much anxiety in parents.
- Trial name
- NCT05458882
- Testing
- "living with food allergy" educational booklet
- Where
- Ireland
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Children's Health Ireland
Peanut Allergy
Early Peanut Introduction: Translation to Clinical Practice
The recent finding that early introduction of peanut can prevent ~70-90% of peanut allergy is a major step towards prevention of food allergy.
- Trial name
- EPI (NCT03019328)
- Testing
- Peanut in diet
- Where
- 2 sites in United States
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Food Allergy, Anaphylaxis
PK/PD Study of IN-001 Sublingual Spray in Healthy Adults
This is an open-label, three-part study to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of epinephrine administered as a single dose of L-dipivefrin (IN-001) sublingual spray or drop in healthy adults.
- Conditions
- Food Allergy, Anaphylaxis, Food Hypersensitivity, Food Allergy Peanut
- Trial name
- NCT07210320
- Testing
- Epinephrine Auto-Injector 0.3 mg/0.3 mL, Epinephrine 0.3 mg intramuscular manual injection via a syringe and needle, IN-001 9.06 mg Sublingual Spray
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Insignis Therapeutics, Inc.
Immune Tolerance
Immunologic Profile of Children With Severe Allergies to Peanuts and Nuts After Induction of Tolerance
Many authors propose the strict avoidance of allergenic food as the only treatment for children known to be allergic to certain food.
- Trial name
- TOY (NCT01996774)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Peanut Allergy
Canadian Peanut Thresholds Study
An important gap in the management of peanut allergy is that we do not know the threshold dose, below which most peanut allergic individuals will not react.
- Trial name
- NCT01812798
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Eosinophilic Gastroenteritis, Eosinophilic Esophagitis
Immunopathogenesis of Food Allergy and Eosinophilic Gastrointestinal Disorders
Background: Food allergies are characterized by abnormal immune system responses to certain foods, such as peanuts, strawberries, and shellfish.
- Trial name
- NCT01212016
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Peanut Allergy
Evaluation of Allergenicity of Hypoallergenic Peanut Product in Peanut Allergic Subjects
This is a proof of concept study to determine the safety and allergenicity of hypoallergenic peanut product extract as compared to standard peanut extract in an adult population with known peanut allergy.
- Trial name
- peanut (NCT01489514)
- Testing
- Epicutaneous skin prick testing
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Allergy, Food Allergy
Efficacy and Saffety of Oral Immunotherapy to Pistachio
The objectives of this study are (i) to evaluate the efficacy of oral immunotherapy to pistachio by evaluating the daily oral tolerance of 2g pistachio, by evaluating the long-term tolerance of 15g pistachio (sustained…
- Trial name
- NCT05698030
- Testing
- Food allergy
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Allergy;Food, Allergy, Nut
Efficacy and Safety of Oral Cashew Nut Immunotherapy in Children (CAJESITO)
The objectives of the CAJESITO study are (i) to assess the tolerance of oral cashew nut immunotherapy, by describing the frequency and severity of allergic reactions during oral cashew nut immunotherapy and (ii )to assess the…
- Trial name
- CAJESITO (NCT05826405)
- Testing
- No intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Food Allergy Peanut, Food Allergy in Infants
Intervention to Reduce Early (Peanut) Allergy in Children
iREACH is a five-year NIH funded study aimed at assessing and improving pediatric clinician adherence to the 2017 NIAID Prevention of Peanut Allergy (PPA) Guidelines.
- Trial name
- iREACH (NCT04604431)
- Testing
- iREACH CDS Tool
- Where
- 30 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Food Hypersensitivity
Impact of Vaccination on Th2 Immunity in Infancy
The purpose of this study is to assess the responses in the immune system of infants after they receive the vaccine against diphtheria, tetanus, and pertussis (DTaP).
- Trial name
- NCT02213341
- Testing
- Skin prick allergen test, Blood draw
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Peanut Allergy, Nut Allergy
Immune-supportive Diet and Gut Permeability in Allergic Children
Peanut and nut allergy can be life threatening. Some patients have very low threshold levels (i.e. the amounts of peanut and nuts to which the patients react), others react to higher doses.
- Trial name
- DIAMETER (NCT05667610)
- Testing
- Immune-supportive diet, Standard care
- Where
- Netherlands
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Peanut Allergy
Peanut Allergy Oral Immunotherapy Desensitization
The purpose of the study is to determine how a type of treatment for peanut allergy known as oral desensitization works in the immune system. Objectives 1.
- Trial name
- NCT01601522
- Testing
- Peanut protein, Oat flour, Antihistamine
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation