Clinical trials: Nutrient Sensing
The Effect of LCFA on Nutrient Absorption
Nutrient Sensing in the Duodenum
Preliminary studies in humans suggest that the presence of lipids in the gut can modify glucose absorption. The overall hypothesis of this proposal is that long chain fatty acid sensing in the duodenum has a significant role in…
- Trial name
- NCT01694004
- Testing
- Benzocaine Infusion into Duodenum
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Healthy Nutrition
Bioavailability of N-acylethanolamines: an Ileostomy Study (NAE Study)
The endocannabinoids (ECs) and N-acylethanolamines (NAEs) are a group of endogenous lipid mediators which have a pleiotropic activity in the body modulating several biological pathways such as: appetite cues, food intake, blood…
- Trial name
- NAE (NCT05845229)
- Testing
- High-N-acylethanolamine meal, Low-N-acylethanolamine meal
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Nutrient Sensing During a Prolonged Fast
Time Course and Nature of Nutrient Sensing During Fasting in Humans
Several studies have begun to determine the time course of events sensing energy availability in rodents. In contrast, there is not a single study that has examined this in humans to date.
- Trial name
- NCT01387919
- Testing
- Prolonged fasting
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Obesity & Overweight, Appetite Regulation
Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adults
Here are both updated sections: Brief Summary: The goal of this clinical trial is to learn if two different doses of dietary supplements delivered to the lower gut can reduce appetite and food intake in obese adults (men and…
- Trial name
- NCT07491835
- Testing
- Arm 1 (Medium Dose): 250mg DIM and 1050mg Perilla oil in GuardCap™ colon-targeted capsules, activating GPR84 and FFA4 to stimulate PYY and GLP-1 release., Arm 2 (Low Dose): 125mg DIM and 525mg Perilla oil in GuardCap™ colon-targeted capsules, activating GPR84 and FFA4 to stimulate PYY and GLP-1 release.
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Queen Mary University of London
Taste Disorder, Secondary, Sweet
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides
The purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of gastrointestinal (GI) satiation peptides by using a specific sweet taste receptor antagonist to block sweet taste…
- Trial name
- NCT01302574
- Testing
- lactisole
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes Mellitus
Metabolic Effects of the Manipulation of Nutrient Sequence in the Main Meals in Type 2 Diabetic Patients
The investigators aimed at evaluating the metabolic effects of the inversion of the typical Italian sequence of food ingestion at the main meals in type 2 diabetic patients.
- Trial name
- NCT02442024
- Testing
- Modified Diet, Standard Diet
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Nutrient Sensing
Nutrient Sensing & Signaling in Aging Muscle
This research seeks to better understand how cellular and molecular bases of changes associated with aging contribute to decreased function and increased incidence of disease.
- Trial name
- NCT02999802
- Testing
- Exercise
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Taste Disorder, Primary, Sweet
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY
The purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of GI satiation peptides by using a specific sweet taste receptor antagonist to block sweet taste perception in the…
- Trial name
- NCT01304823
- Testing
- lactisole, mixed liquid meal
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Irritable Bowel Syndrome
Fecal Amino Acids，Gut Taste Receptors and Irritable Bowel Syndromes
Clinical data, fresh feces and intestinal mucosal tissues of patients with diarrheal IBS were collected. High performance liquid chromatography, immunohistochemistry and immunofluorescence were used to study the amino acid levels…
- Trial name
- NCT06489444
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Obesity & Overweight, Appetite Regulation
Colonic Delivery of DIM and Perilla Oil on Gut Hormones and Food Intake in Obesity
The goal of this clinical trial is to learn whether targeted food supplement capsules that release nutrients in the lower gut can increase appetite-regulating gut hormones and reduce food intake in adults with obesity.
- Trial name
- NCT07448519
- Testing
- Colonic-delivered DIM + Perilla oil
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Queen Mary University of London
Taste Receptors, Nutrient Sensing
The Effect of Artificial Sweeteners on Blood Glucose Response
The purpose of this study is to determine whether the presece of the artificial sweeteners aspartame, saccharin and asceulfame-k affect the blood glucose responses to an orally incested glucose solution.
- Conditions
- Taste Receptors, Nutrient Sensing, Intestinal Absorption, Blood Glucose
- Trial name
- NCT01246492
- Testing
- Artificial Sweeteners
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northumbria University