Clinical trials: Nutrition Disorder
Coronary Artery Disease, Mild Cognitive Impairment
Genomic Outcomes of Metformin
Medical scientists have found that people with diabetes who take the drug Metformin have less age-related disease than those taking other treatments and researchers believe it may prevent numerous diseases and conditions that…
- Conditions
- Coronary Artery Disease, Mild Cognitive Impairment, Obesity, Abdominal, Hypertension
- Trial name
- GOMET (NCT02986659)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Healthy, Obese
A Study to Compare Tablets and Capsules of Orforglipron (LY3502970) in Healthy Participants Who Are Obese or Overweight
The main purpose of this study is to see how much of orforglipron (study drug) gets into the bloodstream and how long it takes the body to get rid of it when given as capsules compared to tablets in healthy overweight and obese…
- Conditions
- Healthy, Obese, Overweight, Obesity
- Trial name
- NCT06440980
- Testing
- Orforglipron
- Where
- 7 sites in United States
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Obesity, Overweight
Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity
This study will look at the change in the participant's body weight from the start to the end of the study. This is to compare the effect on body weight in people taking semaglutide (a new medicine) and people taking "dummy"…
- Trial name
- STEP 2 (NCT03552757)
- Testing
- Semaglutide 1.0 mg, Semaglutide 2.4 mg
- Where
- 147 sites in United States, Argentina and 11 more
- Volunteers
- 1,210 people
- Sponsor
- Novo Nordisk A/S
Obesity
Evaluation of EndoZip System in Obese Patients Who Failed to Reduce Weight With Non-surgical Weight-loss Methods
A multicenter, prospective, single-arm, open-label, controlled clinical trial aimed to evaluate the safety and effectiveness of the EndoZip system procedure, coupled with lifestyle modifications, for weight reduction in obese…
- Trial name
- NCT04773795
- Testing
- EndoZip System
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nitinotes Surgical Ltd.
Obesity, Metabolic Syndrome
Effects of Leptin Replacement in Children
To assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous family. The hypothesis is that leptin replacement will have significant effects on endocrine function.
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00659828
- Testing
- Recombinant methionyl human leptin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Obesity
A Preliminary Comparison of the Blood Levels of Medications in Obese Subjects Compared to Post-Gastric Bypass Subjects
The purpose of this study is to determine the difference, if any, in the area under the sertraline plasma level time curve (AUC) between patients who are nine to fifteen months post Roux-en-Y Bariatric Surgery and control…
- Trial name
- NCT01015976
- Testing
- bariatric surgery, control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Neuropsychiatric Research Institute, Fargo, North Dakota
Metabolic Syndrome, Insulin Resistance
Mechanisms Underlying Metabolic Syndrome in Obesity
The purpose of this study is to better understand the link between obesity and diabetes or pre-diabetes.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Prediabetes
- Trial name
- NCT00579813
- Testing
- Pioglitazone
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Parenteral Nutrition Associated Liver Disease PNALD, Cholestasis
Evaluation of Omegaven™ Parenteral Nutrition in Patients With Total Parenteral Nutrition (TPN)-Induced Cholestasis
The purpose of this study is to determine if established parenteral nutrition (PN) associated liver disease can be reversed or its progression halted by using a parenteral fat emulsion prepared from fish oil as measured by…
- Trial name
- NCT00826020
- Testing
- Omegaven™
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Nebraska
Obesity
Microvascular Flow Assessment Repeatability Study: The MARS Study
The purpose of this study is to test a method of imaging (taking a picture) of the abdomen (belly), neck, thigh and calf (lower leg) areas of the body, using ultrasound along with a drug which makes the pictures look clearer.
- Trial name
- MARS (NCT01242020)
- Testing
- Perflutren Lipid Microsphere Injectable Suspension
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Overweight and Obesity, Physical Activity
Healthy Mom Zone: A Gestational Weight Gain Management Intervention
The purpose is to establish feasibility of delivering an individually-tailored, behavioral intervention to manage gestational weight gain [GWG] that adapts to the unique needs and challenges of overweight/obese pregnant women…
- Conditions
- Overweight and Obesity, Physical Activity, Weight Change, Body, Eating Behavior
- Trial name
- HMZ (NCT03945266)
- Testing
- Intervention group, Control group
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hypophosphatasia (HPP)
Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)
This clinical trial studies the safety and efficacy of asfotase alfa in infants and young children with infantile onset HPP.
- Trial name
- NCT00744042
- Testing
- asfotase alfa
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 11 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Obesity, Nutrition Disorders
Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers
The purpose of this study is to assess the drug concentration of Micafungin amongst healthy volunteers having different weight groups.
- Conditions
- Obesity, Nutrition Disorders, Overweight
- Trial name
- Micafungin (NCT01090141)
- Testing
- Micafungin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Childhood Obesity
Obesity Prevention in Head Start
Family style dining is a widely-advocated approach by which to feed children in early education settings. While family-style dining is hypothesized to allow children to attend to their hunger and satiety and consume only the…
- Trial name
- NCT03672227
- Testing
- Mealtime Matters Training
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Overweight
Effect of Orlistat in Body Composition
The purpose of this study is to determine if a 24 week weight loss program with orlistat 60 mg will produce greater changes in body composition compared to placebo.
- Trial name
- NCT00752726
- Testing
- Orlistat
- Where
- 3 sites in United States, Sweden
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity, Childhood
Storytelling To Prevent Obesity and Encourage Responsive Feeding Practices in Young Children
The goal of this qualitative trial study is to assess the usefulness and acceptability of the intervention in diverse clinical and community settings.
- Trial name
- STORY (NCT05994924)
- Testing
- Educational Handout, Video Series, Group Discussion Sessions
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Overweight, Obesity
Study of a Healthy Lifestyle Intervention for Deaf Adults Who Are Overweight or Obese
The purpose of the Deaf Weight Wise study is to test a 16 week, evidence-based, comprehensive program to change obesity-related health behaviors in Deaf people who use American Sign Language (ASL) as their primary language.
- Trial name
- DWW (NCT01452269)
- Testing
- Deaf Weight Wise program
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Morbid Obesity
Laparoscopic Sleeve Gastrectomy With Endoscopic Visualization
The main objective of this trial is to evaluate endoscopic visualization during a laparoscopic sleeve gastrectomy (LSG) procedure using an endoscope inserted transvaginally through a new device called a Steerable Flex Trocar…
- Trial name
- NCT00911989
- Testing
- NOTES toolbox
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ethicon Endo-Surgery
Pediatric Obesity, Childhood Obesity
A Pharmacokinetic Study Comparing VI-0521 With Placebo in Obese Adolescents
The primary objective of this study is to describe the pharmacokinetic profiles of VI-0521 in obese adolescents.
- Trial name
- NCT02714062
- Testing
- VI-0521 Mid Dose, VI-0521 Top Dose
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- VIVUS LLC
Obesity, Morbid Obesity
Bariatric Surgery for Morbid Obesity
Despite progress in understanding the pathophysiology of obesity, current strategies for its medical management remain largely ineffective.
- Trial name
- NCT00675558
- Testing
- Initial Surgery, Second Bariatric Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Obesity, Apathy
Role of Apathy in the Effectiveness of Weight Loss Interventions
The purpose of this study is to determine whether treating apathy with methylphenidate or medical Crisis counselling will increase adherence to weight loss programs thereby increasing their effectiveness
- Trial name
- NCT00548652
- Testing
- MOVE, medical crisis councelling, methyphenidate
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- VA Nebraska Western Iowa Health Care System
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