Clinical trials: Nutrition Sciences
Type 2 Diabetes, Overweight or Obesity
Effect of Low-calorie Diets With Different Macronutrient Composition and Macronutrient Distribution in Shift Workers With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
Background and Aims: Shift work, particularly involving night shifts, is associated with increased risk of metabolic disturbances such as type 2 diabetes mellitus (T2DM).
- Conditions
- Type 2 Diabetes, Overweight or Obesity, PreDiabetes
- Trial name
- NCT06912555
- Testing
- Diet
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Obesity
To Investigate the Safety, Tolerability and Pharmacodynamics of GSK2890457 in Healthy Volunteers and Subjects With Type 2 Diabetes
This study is the first administration of GSK2890457 in humans. The study will be conducted in 3 parts: - Part A (conducted at a single investigative site) will determine the safety and tolerability of GSK2890457 alone in healthy…
- Trial name
- NCT01725126
- Testing
- GSK2890457, Metformin, Liraglutide
- Where
- 3 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hypercholesterolemia, Vitamin D Deficiency
Effects of Vitamin D on Lipids
The purpose of this study is to examine whether oral vitamin D supplementation in people with inadequate vitamin D concentrations will lower LDL-cholesterol and total cholesterol concentrations.
- Trial name
- NCT00723385
- Testing
- Vitamin D (1000 or 2000 IU/day)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Marasmus
Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan)
This study builds evidence on the importance of using safe drinking water during the nutritional treatment of children affected by Severe Acute Malnutrition (SAM).
- Trial name
- NCT02751476
- Testing
- Point of Use (PoU) water treatment flocculent disinfectant., Point of Use (PoU) water treatment chlorine disinfectant, Point of Use (PoU) ceramic water filter
- Volunteers
- 820 people
- Sponsor
- Action Contre la Faim
Obesity
Influence of Carboxypeptidase D (CPD) Gene on Body Weight and Fat Mass Reduction by Perindopril in Obese Subjects
The primary objective of this study is to evaluate the Carboxipeptidase D (CPD) genotyping as a predictive biomarker of body weight and/or fat mass reduction in obese patients treated with perindopril.
- Trial name
- GPD-01-01 (NCT02777489)
- Testing
- Perindopril
- Where
- 13 sites in Portugal
- Volunteers
- 140 people
- Sponsor
- Gene PreDiT
Mastodynia
Evaluation of Sleep Quality, Nutrition, Anxiety and Depression in Mastalgia
The aim of this study is to investigate the sleep quality, anxiety and depression levels in women with mastalgia using internationally validated scales.
- Trial name
- NCT04690218
- Testing
- Hospital anxiety and depression scale, Pittsburgh Sleep Quality Index, Nutritional Status Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Obesity, Pharmacokinetics
Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations
This study will find how weight affects the dosing of a drug called sulfamethoxazole and trimethoprim. Currently, the amount of sulfamethoxazole and trimethoprim a patient receives is the same regardless of the patient's weight.
- Conditions
- Obesity, Pharmacokinetics, MRSA, Tuberculosis
- Trial name
- NCT01167452
- Testing
- Sulfamethoxazole/trimethoprim
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Crohn's Disease
Efficacy Study of Tripterygium Glycoside Combined With Enteral Nutrition in the Treatment of Crohn's Disease for Induction Remission
The purpose of this study is to assess the effect of Tripterygium Glycosides Combined with enteral nutrition in the treatment of Crohn's disease for induction remission and compare the therapeutic effect with patients who only…
- Trial name
- NCT01820247
- Testing
- enteral nutrition, Tripterygium glycosides
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhu Weiming
Gestational Diabetes, Hyperglycemia
Gestational Metabolic Abnormalities and Maternal and Infant Nutrition and Health
Childhood obesity is on the rise and is a major risk factor for type 2 diabetes later in life. Recent evidence indicates that abnormalities that increase risk for diabetes may be initiated early in infancy.
- Conditions
- Gestational Diabetes, Hyperglycemia, Insulin Resistance, Obesity
- Trial name
- NCT01405547
- Where
- Canada
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Anthony Hanley
Vitamin D Deficiency, Respiratory Tract Infections
Vitamin D Supplementation for the Prevention of Acute Respiratory Infections: a RCT in Young Finnish Men
Vitamin D intervention effects on the prevention of acute respiratory tract infections among Young Finnish Men
- Trial name
- NCT05014048
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Tampere University
Malnutrition, Child
Integrated Livestock Management for Nutrition in Children Under Five Years of Age in Chad
The main objective of this study is to determine the effectiveness of a livestock management intervention, with considerations for animal food security, water contamination from animals, and nutrition counseling, in reducing the…
- Trial name
- NCT05890378
- Testing
- Testing water
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Tufts University
Obstructive Sleep Apnea, Obesity
Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese
This study evaluates the effectiveness of intraoral appliance in the treatment of obstructive sleep Apnea Syndrome in class III obese in comparison to an adjustable silicone appliance.
- Trial name
- NCT03517150
- Testing
- mandibular advancement device
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Pre-diabetes, Obesity
Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls
Aims: 1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic dysfunction in human pre-diabetic obesity? 2.
- Trial name
- NCT00837590
- Testing
- Chronic salsalate, Acute Salsalate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cardiovascular Diseases, Vitamin D Deficiency
The Effect of Vitamin D Statues on Endothelial Function
In the United States, cardiovascular disease causes over one-third of all deaths and vitamin D deficiency is an epidemic. An increasing body of data suggests that low vitamin D status adversely impacts the cardiovascular system.
- Trial name
- CVD Cookie (NCT01049048)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Obesity & Overweight
Retrospective Evaluation of Sibutramine-Topiramate Therapy for Obesity in Real-World Outpatient Practice
This retrospective real-world cohort study aims to evaluate the effectiveness, safety, and tolerability of the combination of sibutramine and topiramate in the treatment of obesity and overweight associated with metabolic…
- Trial name
- SIBUTAMATE (NCT07588750)
- Testing
- Sibutramine + Topiramate
- Where
- Brazil
- Volunteers
- 278 people
- Sponsor
- Falquetomed
OSA - Obstructive Sleep Apnea, Obesity
A Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy
The aim of the study is to assess the efficacy and safety of XW003 injections in obese participants with OSA receiving PAP
- Trial name
- NCT07434050
- Testing
- XW003 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hangzhou Sciwind Biosciences Co., Ltd.
Liver Diseases
Total Parenteral Nutrition-Associated Liver Disease
This is a study to determine whether choline, when added to total parenteral nutrition (TPN), can help prevent the development of hepatic steatosis, a liver disease, in patients on TPN.
- Trial name
- NCT00031135
- Testing
- Choline Chloride
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Northwestern University
Obesity
Effects of Short-term Energy Deficit on Muscle Protein Turnover
Weight loss through energy restriction results in the loss of both fat and muscle mass. Muscle mass is important for mobility, strength, glucose control and energy expenditure, and therefore the retention of muscle mass during…
- Trial name
- NCT02406040
- Testing
- Energy Restriction
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity, Overweight
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis
Obesity, with its associated co-morbidities, is a major public health challenge. It is estimated that by 2050, 60% of men and 50% of women will be clinically obese.
- Trial name
- PRO-ESTER (NCT02451189)
- Testing
- Inulin acetate ester, Inulin propionate ester, Inulin butyrate ester
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Scottish Universities Environmental Research Centre
Obesity
Does Bariatric Surgery Changes Eating Habits and Addiction in Morbid Obesity?
1. Obesity is a big health problem worldwide. 2. Mostly obese people have food addiction and bad eating habits. 3. Bariatric surgery is a good alternative for patients who failed to loose weight with other measures like…
- Trial name
- NCT01412268
- Volunteers
- 35 people
- Sponsor
- Bezmialem Vakif University
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