Clinical trials: Nutritional Deficiencies
ALS
Riluzole Oral Soluble Film Safety and Tolerability in Amyotrophic Lateral Sclerosis
The primary objective of this study is to assess the safety and tolerability, with emphasis on the oral cavity, of ROSF (containing riluzole 50mg) in subjects with amyotrophic lateral sclerosis (ALS) administered twice daily for…
- Trial name
- NCT03457753
- Testing
- Riluzole Oral Soluble Film
- Where
- United States
- Sponsor
- Aquestive Therapeutics
Iron Deficiency Anemia (IDA), Nutrition Disorders
Nutritional Educational Program On Therapy in Iron Deficiency Anemia
The goal of this clinical trial is to evaluate whether a Nutritional Educational Program for caregivers can improve their knowledge and performance in managing iron deficiency anemia (IDA) in children, compared to oral iron…
- Conditions
- Iron Deficiency Anemia (IDA), Nutrition Disorders, Growth Retardation
- Trial name
- NEPOT-IDA (NCT06642337)
- Testing
- Educational program
- Where
- Iraq
- Volunteers
- 180 people
- Sponsor
- Hawler Medical University
Multiple Myeloma and Plasma Cell Neoplasm
4'-Iodo-4'-Deoxydoxorubicin in Treating Patients With Primary Systemic Amyloidosis
RATIONALE: 4'-Iodo-4'-deoxydoxorubicin may improve organ dysfunction and ease symptoms caused by primary systemic amyloidosis. PURPOSE: Phase II trial to study the effectiveness of 4'-iodo-4'-deoxydoxorubicin in treating patients…
- Trial name
- NCT00003853
- Testing
- 4'-iodo-4'-deoxydoxorubicin
- Where
- 3 sites in United States, Italy
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Mitochondrial Respiratory Chain Deficiencies
Abdominal Adiposity and Muscle Mitochondrial Functions
Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance.
- Trial name
- Mithycal (NCT00446745)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Vitamin D Deficiency
Vitamin D Status and Its Influencing Factors in Zhejiang Province: A Multicenter Cross-Sectional Study
Vitamin D deficiency is a global public health problem, with an estimated 1 billion people affected worldwide, and large-scale systematic data for Zhejiang Province remain scarce.
- Trial name
- NCT07866391
- Where
- 2 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hepatitis C, Hemodialysis
Effect of HCV Infection on Insulin Resistance and Malnutrition-inflammation Complex Syndrome in Regular Hemodialysis Patients
The purpose of this study is to study whether hepatitis C virus (HCV)infected maintenance hemodialysis (MHD)patients have distinct metabolic, inflammatory and adipokine characteristics that can be linked to poor clinical outcome…
- Conditions
- Hepatitis C, Hemodialysis, Quality of Life, Mortality
- Trial name
- NCT00527774
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- St. Martin De Porress Hospital
Vitamin A Deficiency
Vitamin A, Stool Microbiota and Vaccine Response in Bangladeshi Infants
Vitamin A deficiency (VAD) increases the risk of death from infections in infants and young children. The World Health Organization (WHO) recommends high-dose vitamin A supplementation (VAS) from 6-59 months of age to reduce the…
- Trial name
- NCT02027610
- Where
- 3 sites in United States, Bangladesh
- Volunteers
- 258 people
- Sponsor
- USDA, Western Human Nutrition Research Center
Osteoporosis, Aging
Vitamin D Supplementation in Older Women
The purpose of this study is to examine the effects of several doses of vitamin D on hormones related to bone, calcium absorption, bone density and muscle strength.
- Trial name
- VIDOS (NCT00472823)
- Testing
- Vitamin D3, Calcium Citrate (Citracal)
- Where
- United States
- Volunteers
- 273 people
- Sponsor
- Creighton University
Amyloidosis
A PILOT Study on LSGB vs EMB in the Diagnosis of Cardiac Transthyretin Amyloidosis
Transthyretin (TTR) is a plasma protein mainly synthesized in the liver, recognized as a transporter of thyroxine and retinol-binding protein.
- Trial name
- NCT05375279
- Testing
- Lip Salivary Gland Biopsy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Iron-deficiency
Iron Bioavailability of High Surface Area Ferric Phosphate
The primary objective of this study is to compare iron absorption of high surface area ferric phosphate with that of ferrous sulfate and bulk ferric phosphate in a rice-based meal in non-pregnant women.
- Trial name
- HiFe (NCT03660462)
- Testing
- FeSO4 fortified rice test meal, FePO4 fortified rice test meal, HiFePO4 1 fortified rice test meal
- Where
- Thailand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Primary Progressive Nonfluent Aphasia
A 24-month Phase 1 Pilot Study of AADvac1 in Patients With Non Fluent Primary Progressive Aphasia
This study is a pilot trial evaluating the safety and immunogenicity of AADvac1 in patients with the non-fluent variant of Primary Progressive Aphasia.
- Trial name
- AIDA (NCT03174886)
- Testing
- AADvac1 40 µg, AADvac1 160 µg
- Where
- 3 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Axon Neuroscience SE
Frontotemporal Lobar Degeneration
Natural History Characterization in Symptomatic and Asymptomatic Progranuline Gene Mutation Carriers
The purpose of this study is to investigate whether cognitive deficits, structural and functional changes can be detected before symptom onset in presymptomatic progranuline mutation carriers.
- Trial name
- Predict-PGRN (NCT04014673)
- Testing
- Behavioral : Characterization
- Where
- 2 sites in France
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Iron-deficiency
Mechanism of Hypersensitivity Reactions to Iron Nanomedicines
Iron deficiency is common and when oral treatment is not sufficient intravenous application is indicated. Hypersensitivity to intravenous iron nanomedicines is rare but does occur and little is known about the underlying…
- Trial name
- NCT03508466
- Testing
- hypersensitivity reaction
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Basel, Switzerland
AL Amyloidosis, Smoldering Multiple Myeloma
Promoting Diagnosis and Management of AL in Italy (ProDigALIty)
The investigators plan to establish a dedicated network of Italian Hematologic Departments interconnected with the Amyloidosis Research and Treatment Center in Pavia to: 1.
- Conditions
- AL Amyloidosis, Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance
- Trial name
- ProDigALIty (NCT06383143)
- Testing
- no intervention
- Where
- 4 sites in Italy
- Volunteers
- 760 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Severe Acute Malnutrition in Childhood
Severe Acute Malnutrition and Child Development Clinical Trial in Mwanza
This is a randomized clinical trial to learn whether ready-to-use therapeutic foods enriched with choline and docosahexaenoic acid (DHA) together with psychosocial stimulating activities work well to improve child development in…
- Trial name
- BRIGHTSAM (NCT06781918)
- Testing
- Ready to Use Therapeutic Food (RUTF), Psychosocial stimulation
- Where
- Tanzania
- Volunteers
- 800 people
- Sponsor
- National Institute for Medical Research, Tanzania
Anemia, Iron Deficiency, Colorectal Surgery
Impact of Iron Infusion in Anemic Patients on Their Postoperative Outcome After Colorectal Surgery
In 2005, colorectal surgery in France represented nearly 40,000 procedures per year, of which 80% were scheduled and 70% were for carcinological purposes.
- Trial name
- IRON_PREHAB (NCT05522790)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Dementia, Dementia, Vascular
Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
The goal of this clinical trial is to improve communication among clinicians, patients with memory problems, and their family members.
- Conditions
- Dementia, Dementia, Vascular, Mixed Dementias, Alzheimer Disease
- Trial name
- PICSI-M (NCT05596760)
- Testing
- Jumpstart Guide
- Where
- 3 sites in United States
- Volunteers
- 1,802 people
- Sponsor
- University of Washington
Vitamin A Deficiency, Iron-deficiency
Impact of Food-to-Food Fortified Cereal Products on Diet Quality in Eldoret, Kenya
The overall hypotheses is that a product designed with optimized nutritional characteristics, based on consumer preferences and leveraging local nutrient dense ingredients, can successfully deliver nutrition through sustainable…
- Trial name
- KenyaMPS (NCT05882682)
- Where
- Kenya
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Purdue University
Iron Deficiency, Anemia; Deficiency, Nutritional, With Poor Iron Absorption
A Study to Investigate the Effect of Vitamin D3 Supplementation on Iron Status in Iron Deficient Women
Iron is one of the most vital elements in humans as it plays a role in physiological functions such as transferring and storing oxygen, transporting electrons and catalysing numerous reactions, from oxidative metabolism to…
- Conditions
- Iron Deficiency, Anemia; Deficiency, Nutritional, With Poor Iron Absorption, Vitamin D Deficiency
- Trial name
- NCT02714361
- Testing
- Vitamin D3 supplement
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chester
Hypertension, Pulmonary, Anemia, Iron Deficiency
ORal IrON Supplementation With Ferric Maltol in Patients With Pulmonary Hypertension (ORION-PH-1)
This is an explorative, open-label, uncontrolled, single center study to explore the preliminary safety, tolerability and efficacy of oral ferric maltol in treating iron deficiency in patients with pulmonary hypertension and iron…
- Trial name
- ORION-PH-1 (NCT03371173)
- Testing
- Ferric maltol 30 mg (Feraccru®)
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Hannover Medical School
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