Clinical trials: Nutritional Deterioration
Nursing Homes Residents, Deterioration, Clinical
Clinical Assessment and Treatment in the Nursing Home as an Alternative to Hospital Admission
This multicenter, cluster-randomized, unblinded quality-improvement study evaluates whether home-based clinical assessment by municipal acute care teams can safely reduce hospital admissions among nursing home residents…
- Conditions
- Nursing Homes Residents, Deterioration, Clinical, Infection, Dehydration
- Trial name
- NCT07756554
- Testing
- Home-based Clinical Assessment and Treatment
- Where
- 4 sites in Denmark
- Volunteers
- 9,000 people
- Sponsor
- Copenhagen University Hospital at Herlev
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research
Cardiomyopathies, Insulin Resistance
Early MRI Detection of Myocardial Deterioration as a Preventive, Disease Staging, and Prognostic Biomarker in Insulin Resistance
The purpose of this study is to evaluate the relationship between insulin resistance (IR) and myocardial tissue abnormalities. The study will focus on a patient population, South Asians, with a high prevalence of IR.
- Conditions
- Cardiomyopathies, Insulin Resistance, Non-ischemic Cardiomyopathy, Cardiac Fibrosis
- Trial name
- NCT03509441
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes Mellitus (DM)
Metatarsal Phalangeal Joint Deformity Progression - R01
The purpose of this research study is to determine the relationships between foot muscle, foot motion, and toe deformity. Results from this investigation will help the investigators to understand what contributes to foot…
- Trial name
- NCT02616263
- Testing
- Foot exercise, Shoulder exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Myocardial Infarction, Acute
Effect of INtravenous FERRic Carboxymaltose Onmortality and Cardiovascular Morbidity, and Quality of Life in Iron Deficient Patients With Recent Myocardial infarCTion
Non-commercial, multicentre, randomised, double-blind, parallel group, placebo-controlled clinical trial. Eligible patients were randomly assigned (1:1) using a secure, central, interactive, web-based response system, to…
- Trial name
- INFERRCT (NCT05759078)
- Testing
- Ferinject, Sodium Chloride 0.9% Inj
- Where
- 43 sites in Poland
- Volunteers
- 1,000 people
- Sponsor
- Wroclaw Medical University
Anorexia Nervosa Restricting Type, Anorexia Nervosa (DSM-IV Revised Criteria)
Biomarkers in EV Associated With Marrow Adiposity in Anorexia
The aim of this observational study is to identify biomarkers in extracellular vesicles associated with medullary adiposity occurring in patients with anorexia nervosa.
- Trial name
- VE_BMAT_AN (NCT06712485)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Gestational Diabetes
Is Fat in the Liver a Marker of Post-Pregnancy Glycaemic Deterioration in Women With Gestational Diabetes?
The aim of this study is to utilise ultrasound, using an established method for detecting NAFLD, to determine whether the presence of NAFLD in women with GDM, detected during routine scanning, is a marker of deterioration in…
- Trial name
- FLiP-GD2 (NCT04362540)
- Testing
- MRI scan
- Where
- United Kingdom
- Volunteers
- 189 people
- Sponsor
- University Hospitals of North Midlands NHS Trust
Gestational Diabetes
Prevention of Gestational Diabetes
Gestational diabetes mellitus (GDM)is a major health problem growing prevalence of obesity the older age of pregnant women A randomized controlled trial in 54 pregnant voluntary women at high risk for GDM.
- Trial name
- NCT01130012
- Testing
- Lifestyle: diet and exercise, Close follow-up: reporting diaries of food and exercise
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Vitamin D Deficiency, Hyperparathyroidism
Abnormally High Parathyroid Hormone Levels Worsens Outcomes in Vitamin D Depleted Critical Care Patients
This study aims to investigate the impacts of abnormally elevated PTH levels on clinical outcomes among critically ill patients with vitamin D depletion.
- Conditions
- Vitamin D Deficiency, Hyperparathyroidism, Critically Ill Patients Admitted in ICU
- Trial name
- NCT06711874
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Taiwan University Hospital
Osteoporosis, Atypical Femoral Fractures
Pathogenesis of Atypical Femur Fractures on Long Term Bisphosphonate Therapy
The purpose of this protocol is to determine the risk of atypical femoral shaft (thigh bone) fractures after long term fracture prevention therapy with a class of drugs called "bisphosphonates", colloquially referred to as…
- Conditions
- Osteoporosis, Atypical Femoral Fractures, Prodromal Bone Deterioration
- Trial name
- NIH fracture (NCT02155595)
- Testing
- 500 without BP treatment, 500 with BP treatment
- Where
- United States
- Volunteers
- 738 people
- Sponsor
- Henry Ford Health System
Osteopenia, Osteoporosis
Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Women
The purpose of this study is to evaluate the changes in bone structure as determined by magnetic resonance imaging measurements among early postmenopausal women after 24 months of treatment with alendronate, 70 mg once a week as…
- Trial name
- NCT00504166
- Testing
- alendronate sodium
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of California, San Francisco
Nutritional Deterioration, Malignant Solid Tumor
Benefits of Nutritional Supplement in Cancer Care
This is an exploratory, open-label, 2:1 randomized controlled trial conducted across collaborating oncology clinics and extended research networks in Hong Kong.
- Conditions
- Nutritional Deterioration, Malignant Solid Tumor, Cancer Cachexia, Cancer Malnutrition
- Trial name
- NCT07869290
- Testing
- Nutrition supplement, Digital Health App Monitoring, Individualized Dietitian Consultation
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Amyotrophic Lateral Sclerosis
Sport Therapy and Osteopathy Manipulative Treatment in ALS
This project assessed muscle oxidative metabolism and fatigue in patients affected by amyotrophic lateral sclerosis (ALS) undergoing to three months of individualized cardiovascular and strength training.
- Trial name
- ME_E_SLA (NCT02548663)
- Testing
- Sport therapy, Osteopathic treatment
- Volunteers
- 30 people
- Sponsor
- University of Milano Bicocca
Exercise, Metabolic Syndrome
Exercise Effects on Health Status in Patients With Severe Mental Illness
People with severe mental disorders have a mortality rate 2 to 3 times higher than that of the general population, largely due to the presence of comorbidities, with a predominance of cardiovascular disease.
- Conditions
- Exercise, Metabolic Syndrome, Mental Disorders, Severe, Severe Mental Disorder
- Trial name
- SMI01 (NCT05834309)
- Testing
- Physical exercise
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Pública de Navarra
Heart Transplantation
METABolic Deterioration in HTX Determines Outcomes
METAB-HTX is a prospective, longitudinal cohort study evaluating cardiac and systemic metabolism in heart transplant recipients.
- Trial name
- METAB-HTX (NCT07372820)
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Metabolic Disturbance, Schizophrenia
Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication?
Background and objective: Clozapine and olanzapine are some of the most effective antipsychotic drugs, but unfortunately, both drugs induce weight gain and conveys a high degree of metabolic disturbances.
- Conditions
- Metabolic Disturbance, Schizophrenia, Type 2 Diabetes, Clozapine
- Trial name
- NCT04892199
- Testing
- Semaglutide, 1.34 mg/mL
- Where
- 3 sites in Denmark
- Volunteers
- 104 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Type 1 Diabetes
Prevention of Self-care Deterioration in Early Adolescents With Diabetes
Establish the efficacy of a brief, clinic-based prevention program of teamwork coping skills for youth and their parents during in a high risk period of early adolescence (11-14 yrs) when parental involvement and self-care…
- Trial name
- NCT00890331
- Testing
- TeamWork CS Sessions, Diabetes Education
- Where
- 2 sites in United States
- Volunteers
- 285 people
- Sponsor
- Virginia Commonwealth University