Clinical trials: OA
Knee Osteoarthritis
Efficacy Study on Symptomatic Control of Patient With Knee Osteoarthritis Between 14% of Plai (Plaivana®) to Placebo Gels
To determine whether plai cream is effective in treating mild to moderate degrees of osteoarthritis of the knee in the elderly patient compared with placebo cream.
- Trial name
- OA knee Plai (NCT01836393)
- Testing
- Plavina cream
- Where
- 2 sites in Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Osteoarthritis, Knee, Self Stimulation
Exercise and Muscle Stimulation in Patients With Knee Osteoarthritis
Objective: To evaluate the effectiveness of neuromuscular electrical stimulation (NMES) combined with closed kinetic chain (CKC) exercises in patients with knee OA.
- Conditions
- Osteoarthritis, Knee, Self Stimulation, Exercise Addiction
- Trial name
- NCT01320904
- Testing
- NMES, Closed Kinetic Chain
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidade Luterana do Brasil
Osteoarthritis (OA)
Research on the Pathogenesis and Therapeutic Targets of Articular Cartilage Degeneration in Osteoarthritis
Before you are included in this study, you will undergo the following examinations to determine if you are eligible to participate: Before you are included in this study, your doctor will ask and record your medical history…
- Trial name
- NCT07796607
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yunnan University of Chinese Medicine
Acute Injury of Anterior Cruciate Ligament
Feasibility Trial Using Imaging and Biochemical Technologies to Measure Knee Cartilage Composition in Acute ACL Injury
This study will evaluate the bio-mechanical and biochemical abnormalities in acute ACL-injured knees over time. Data will be collected through advanced quantitative MR imaging, functional testing, and bio-specimen collection.
- Trial name
- NCT02010125
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Knee Osteoarthritis
TENS Effectiveness and Knee Osteoarthritis in Humans
TENS is a non pharmacological intervention to control pain. Both high (>50 Hz) and low (<10 Hz) frequency TENS are used in the clinic and it is thought that each type works through different mechanisms (see for review Sluka and…
- Trial name
- TOPS (NCT01354054)
- Testing
- High Frequency TENS, Low frequency TENS
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Knee Osteoarthritis
GLUCOSAMINE/CHONDROITIN and PHYSICAL THERAPY EFFECTS ON OLDER POPULATION WITH KNEE OSTEOARTHRITIS
to see the effect of glucosamine chondratin sulfate with and without physiotherapy in knee osteoarthritis
- Trial name
- NCT05321836
- Testing
- Glucosamine Chondroitin, glucosamine chondritin & Physiotherapy
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Muhammad salman, PT
Chronic Neck Pain, Chronic Low Back Pain
Group Acupuncture Therapy With Modified Yoga
Chronic pain is prevalent in the U.S., with impact on physical and psychological functioning as well as lost work productivity. Minority and lower socioeconomic populations have increased prevalence of chronic pain with less…
- Conditions
- Chronic Neck Pain, Chronic Low Back Pain, Osteoarthritis Pain
- Trial name
- GAPYOGA (NCT04296344)
- Testing
- Acupuncture Therapy Treatments, Yoga Therapy Sessions
- Where
- 3 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Osteoarthritis of the Knee
Evaluating the Safety and Efficacy Civamide in Osteoarthritis (OA) of the Knee(s)
To evaluate the safety and efficacy of Civamide Cream 0.075% as a treatment of the signs and symptoms associated with osteoarthritis of the knee.
- Trial name
- NCT00995306
- Testing
- Civamide (Zucapsaicin)
- Volunteers
- 695 people, healthy volunteers welcome
- Sponsor
- Winston Laboratories
Hyperalgesia, Pain Perception
Session-Order Sensitivity of TS and OA in a Capsaicin Crossover Model
Temporal summation (TS) and offset analgesia (OA) are widely used psychophysical endpoints in pain research that index different components of central nociceptive processing.
- Conditions
- Hyperalgesia, Pain Perception, Central Nervous System Sensitization, Pain Threshold
- Trial name
- TS-OA-Cap (NCT07625475)
- Testing
- Topical 0.075% capsaicin cream (Zostrix), Topical vehicle lotion (Lubriderm)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Osteoarthritis, Knee
Core Activation and Stabilization for Knee OA
This will be the second investigation by the PI and sub-investigator on this topic, following the promising results of a pilot study on a small sample size (N=5) completed last year.
- Trial name
- NCT03776981
- Testing
- Core Activation, Core Stabilization
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Healthy, Osteoarthritis
Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation
This is a first in human, randomized, double-blind, placebo-controlled SAD (with food effect) followed by a MAD study of Trichomylin® conducted in healthy adult participants.
- Trial name
- HOPE (NCT04867057)
- Testing
- Trichomylin for SAD, Trichomylin for MAD
- Where
- Australia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- ZYUS Life Sciences Inc.
Respiratory Syncytial Virus Infections
An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 Study
The purpose of this study is: To investigate the optimal timing for revaccination after the initial RSVPreF3 OA vaccine dose, To evaluate the long-term immune persistence and safety up to 5 consecutive RSV seasons (approximately…
- Trial name
- RSV OA=ADJ=012 (NCT06534892)
- Testing
- RSVPreF3 OA vaccine
- Where
- 251 sites in United States, Australia and 15 more
- Volunteers
- 10,212 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lower-limb Orthoses, Osteoarthritic Knee Pain
Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal
The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations.
- Conditions
- Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
- Trial name
- NCT07673328
- Testing
- Modular powered orthosis
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoarthritis, Osteoarthritis (OA) of the Knee
A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches
The goal of this clinical trial is to evaluate the skin safety of a soluble denosumab microneedle patch in participants with osteoporosis and osteoarthritis.
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoporosis, Osteoporosis (Senile)
- Trial name
- CSEDSSDMP (NCT07085520)
- Testing
- Microneedle with 0.24mg Denosumab, Saline Microneedle Patch, Microneedle with 1.2mg Denosumab
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Diabetes Mellitus, Type 2
Correlation Between the Pulmonary Function Parameters and the Circulatory Parameters (PSV, EDV, RI) of Retrobulbar Blood Vessels (CRA, PCA, and OA) in 48 T2DM Patients Did Not Combinate With DR
Objective: The main target of this study was to research the correlation between the pulmonary function and the circulatory parameters of retrobulbar blood vessels in patients with type 2 diabetes (T2DM) without diabetic…
- Trial name
- CPCT2DM (NCT02774733)
- Testing
- spirometer;Intraocular pressure;Color doppler imaging
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fourth People's Hospital of Shenyang
Osteoarthritis, Knee
Reducing Knee Compression When Sleeping in Those With Knee OA
To determine whether a change in sleeping position so as to prevent the knee being 'pushed' into full extension when lying supine provides pain relief and/or symptom improvement in individuals with knee osteoarthritis (OA).
- Trial name
- NCT04188054
- Testing
- Change in sleeping position, No change in sleeping position
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Bradford
Knee Osteoarthritis (Knee OA)
Cross-linked Hyaluronic Acid in Knee Osteoarthritis
Knee Osteoarthritis (Knee OA) leads to pain and loss of function, especially in recreational athletes. While hyaluronic acid (HA) injections are a common part of conservative treatment, comparative data on the efficacy of…
- Trial name
- NCT07241442
- Testing
- Straight-bonded hyaluronic acid, cross-linked hyaluronic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Knee Osteoarthritis
Derris Scandens Benth Extract VS Naproxen in Knee OA
Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia.
- Trial name
- NCT00503828
- Testing
- Derris scandens Benth extracts, naproxen
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University