Clinical trials: OA
Knee Osteoarthritis
The Effect of Mobilization on Inflammatory Biomarkers in Patients With Knee Osteoarthritis.
This study is designed to investigate whether a hands-on therapy called Mobilization with Movement (MWM) can reduce pain and inflammation in individuals with knee osteoarthritis (OA).
- Trial name
- NCT07166068
- Testing
- Manual Therapy (Mobilization with Movement), Exercise
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- University of Jazan
Knee Osteoarthritis
To Investigate the Effect of PEMF for Knee OA Patients
Health care costs are increasing alarmingly, which will impose an overwhelming economic burden to an aging society like that of Hong Kong.
- Trial name
- NCT05442697
- Testing
- PEMF treatment
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis (OA) of the Knee, Osteoarthritis
Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis
The aim of this study is to compare functional and clinical outcomes of intraarticular injections of hyaluronic acid and steroids in patients with bilateral knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Osteoarthritis, Osteoarthritis in the Knee, Osteoarthritis of Knee
- Trial name
- NCT06717529
- Testing
- Sodium hyaluronate (hyaluronic acid), Methylprednisolone Acetate Injection
- Where
- Bosnia and Herzegovina
- Volunteers
- 65 people
- Sponsor
- Edin Mešanović
Esophageal Atresia With Tracheoesophageal Fistula
Swallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF)
How does oesophageal atresia/trache-oesophageal fistula affect feeding and swallowing in the first year of life? Approximately 150 babies a year are born with oesophageal atresia and/or trache-oesophageal atresia.
- Trial name
- SaFE (NCT04183621)
- Testing
- high resolution impedance manometry
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Osteoarthritis (OA) of the Hip
PENG Block & PENG PRF
The primary aim of this study is to prospectively compare the effects of the pericapsular nerve group (PENG) block alone and the combination of PENG block with pulsed radiofrequency (PRF) on pain intensity in patients with…
- Trial name
- PENG-PRF (NCT07360093)
- Testing
- PENG Block Pulsed radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara City Hospital Bilkent
Knee Osteoarthritis
Condrosulf vs Celebrex vs Placebo in the Treatment of Knee OA
The purpose of this study is to confirm the efficacy and safety of 800 mg Chondroitin 4\&6 sulfate (Condrosulf) vs placebo once a day for 6 months in the symptomatic treatment of knee osteoarthritis.
- Trial name
- NCT02079727
- Testing
- chondroitin sulfate, celecoxib
- Where
- 16 sites in Belgium, Czechia and 3 more
- Volunteers
- 604 people
- Sponsor
- IBSA Institut Biochimique SA
Knee Osteoarthritis (Knee OA)
Muscle Isometric Contraction for the Treatment of Knee Osteoarthritis
This study compares the effects of three different intensities of Muscle Isometric Contraction (MIC) on balance ability, proprioception, muscle strength, KOA symptoms, and inflammatory factors in synovial fluid among elderly…
- Trial name
- KOA (NCT06870656)
- Testing
- Low-intensity group, Medium-intensity group, High-intensity group
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chengdu Sport University
Knee Osteoarthritis (OA)
Altered Joint Mechanics and Biological Response in Osteoarthritic Knees.
Osteoarthritis (OA) stands out as the most prevalent joint disease. It manifests as a progressive degradation of articular cartilage, new bone growth and often synovial tissue proliferation, resulting in pain and compromised…
- Trial name
- AMB-OK (NCT07481461)
- Testing
- Photon counting CT scanning (PCCT scanning), Magnetic resonance imaging (MRI scanning), Gait analysis
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Thumb Osteoarthritis, Hand Osteoarthritis
Assessment and Comparison of Efficacy of Intra-Articular PRP and Corticosteroid in First CMC Joint OA Treatment
Aim: We aim to determine and compare the efficiency of single dose intra-articular (IA) platelet rich plasma (PRP) and corticosteroid (CS) injections for the treatment of first carpometacarpal joint osteoarthritis (1.
- Conditions
- Thumb Osteoarthritis, Hand Osteoarthritis, Platelet Rich Plasma, Corticosteroid
- Trial name
- NCT06657300
- Testing
- PRP, Corticosteroid
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Antalya Training and Research Hospital
Knee Osteoarthritis
Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients
This is a 2-year double-blind randomized controlled trial in 287 community-dwelling individuals age 60 years or older undergoing uni-lateral total knee replacement due to severe OA of the knee.We compare an oral dose of 2000 IU…
- Trial name
- NCT00599807
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Switzerland
- Volunteers
- 273 people
- Sponsor
- University of Zurich
Osteoarthritis, Knee
Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee
Safety \& Efficacy of FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to Osteoarthritis of the Knee.
- Trial name
- OA (NCT03441607)
- Testing
- mHACMb
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Applied Biologics, LLC
Knee Osteoarthritis (Knee OA), Chronic Pain
Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
The goal of this clinical trial is to examine the effects of duloxetine on walking ability and physical activity in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis (Knee OA), Chronic Pain, Chronic Knee Pain
- Trial name
- PACE-UP (NCT07759336)
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Benedict Alter
Knee Osteoarthritis
High-speed Power Training in Older Adults With Knee Osteoarthritis (OA)
We are exploring a unique weight-training program for men and women 55 years or older with knee osteoarthritis (OA) that emphasizes high-speed movements.
- Trial name
- NCT01328340
- Testing
- High-speed power training, Slow-speed strength training
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Knee Osteoarthritis
Allogeneic Bone Marrow MSC Therapy for Knee Osteoarthritis
The Clinical trial is a phase I/IIa clinical study for treatment of knee osteoarthritis by intra-articular injection of bone marrow derived allogeneic mesenchymal stem cells.
- Trial name
- NCT03589287
- Testing
- Chondrochymal®
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gonarthrosis, Knee Osteoarthritis
Evaluation of Intra-articular Injection of Autologous Protein Solution ("APS(TM)") for the Treatment of Osteoarthritis (OA)
This prospective single-center study will evaluate the safety and tolerability of a single dose of "APS(TM)" treated patients with OA of the knee who have failed conservative OA therapy.
- Conditions
- Gonarthrosis, Knee Osteoarthritis, Osteoarthritis
- Trial name
- NCT01773226
- Testing
- Autologous Protein Solution "APS(TM)"
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Zimmer Biomet
Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
Safety and Efficacy Study of GRT6005 in Patients With Osteoarthritis (OA) Knee Pain
The purpose of this study is to evaluate the safety and efficacy of GRT6005 compared to placebo in patients with moderate to severe chronic pain due to osteoarthritis (OA) of the knee.
- Trial name
- NCT01709214
- Testing
- Cebranopadol (GRT6005) Low-Dose Range, Cebranopadol (GRT6005) High-Dose Range, Oxycodone CR
- Where
- 83 sites in United States
- Volunteers
- 619 people
- Sponsor
- Tris Pharma, Inc.
Osteoarthritis
Etoricoxib vs. Diclofenac in OA (0663-805)(COMPLETED)
To compare the safety and tolerability of etoricoxib and diclofenac sodium in the treatment of osteoarthritis of the knee or hip during a six week period.
- Trial name
- NCT00542087
- Testing
- MK0663, etoricoxib / Duration of Treatment: 6 Weeks, Comparator: diclofenac sodium / Duration of Treatment: 6 Weeks
- Volunteers
- 516 people
- Sponsor
- Organon and Co
Osteoarthritis (OA) of the Knee
Comparison of Postoperative Functional Outcomes Between Subvastus and Medial Parapatellar Approach in Total Knee Arthroplasty
This study aims to compare the effects of the medial parapatellar approach (MP) and the subvastus approach (SV) on postoperative clinical function in total knee arthroplasty (TKA).
- Trial name
- NCT07742696
- Testing
- subvastus, medial parapatellar
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Peking University Third Hospital
Knee Osteoarthritis
Effects of ITB Myofascial Release on Symptoms Associated With Knee OA.
The aim of this randomized controlled trial is to determine the effects of ITB myofascial release with graston technique on symptoms associated with knee Osteoarthritis for reducing pain, enhancing knee range of motion and…
- Trial name
- NCT06109038
- Testing
- Conventional PT + ITB release with graston technique, Conventional PT
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Osteoarthritis of the Knee
Can Computer-based Telephone Counseling Improve Long-term Adherence to Strength Training in Elders With Knee OA?
The purpose of this research is to determine whether computer-based telephone counseling will improve adherence to strength training in a population of elders with knee osteoarthritis.
- Trial name
- BOOST (NCT01394874)
- Testing
- TLC
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston University Charles River Campus