Clinical trials: OA Knee
Osteoarthritis Knee, Corticosteroid
Intra-articular Platelet Rich Plasma vs Corticosteroid in Treatment of Knee Osteoarthritis Patients
Knee osteoarthritis is the most common type of osteoarthritis in the lower extremity and constitutes 23% of all arthritis cases, about 13% of females and 10% of males aged above 60 years have symptomatic knee OA.
- Conditions
- Osteoarthritis Knee, Corticosteroid, Platelet Rich Plasma
- Trial name
- NCT05742061
- Testing
- Corticosteroid, Platelet Rich Plasma
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Benha University
Osteoarthritis, Knee, Hypertension
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study
Diet interventions (e.g., low-energy diets) are recommended as a treatment for obesity, obese patients with osteoarthritis, hypertension (HTN), and type 2 diabetes (T2D).
- Conditions
- Osteoarthritis, Knee, Hypertension, Type 2 Diabetes, Obesity
- Trial name
- NCT05735873
- Testing
- Low-energy diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Musculoskeletal Diseases, Osteoarthritis, Knee
Epidemiology and Nutrition
The general purpose of this study is to evaluate the relation between the nutritional status of patients, the features of the orthobiologics products used for patients' treatment and the clinical outcomes after one-step…
- Conditions
- Musculoskeletal Diseases, Osteoarthritis, Knee, Nutrition, Healthy
- Trial name
- Nutririsk (NCT05546541)
- Where
- Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteoarthritis, Knee
The Osteoarthritis Prevention Study
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or…
- Trial name
- TOPS (NCT05946044)
- Testing
- Diet and Exercise
- Where
- 4 sites in United States, Australia
- Volunteers
- 1,230 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Knee Osteoarthritis
Anatomic Congruent Prosthetic Knee Design
This double-blinded randomized control study will use kinematic and kinetic measures to compare an anatomical congruent prosthetic knee design to a standard prosthetic knee design.
- Trial name
- NCT03633201
- Testing
- Cruciate Retaining, Medial Congruent
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Osteoarthritis, Knee
Study of Various Insoles in Patients With Knee Osteoarthritis
It is critical to improve our understanding of knee osteoarthritis and to design better therapeutic options for this disease. The function of the knee during walking is an important factor in the development and progression of…
- Trial name
- NCT02530684
- Testing
- insole
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Osteoarthritis, Knee
Mobilizing Hispanics With Knee Osteoarthritis
The objective is to conduct an early-stage clinical trial in order to provide data required to support a future clinical trial to demonstrate the effectiveness of a culturally acceptable treatment program to increase exercise and…
- Trial name
- NCT06522906
- Testing
- Muscle Strengthening, General Physical Activity, Education
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Knee Injuries, Knee Osteoarthritis
Blood-Flow Restriction Exercise Following a Knee Replacement
This study will determine the safety and efficacy of using blood-flow restriction exercise enhancement (B-FREE) to overcome persistent quadriceps muscle weakness that occurs following a total knee replacement (TKR).
- Conditions
- Knee Injuries, Knee Osteoarthritis, Knee Arthritis
- Trial name
- NCT04018638
- Testing
- B-FREE
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Michigan Technological University
Osteoarthritis, Knee
MR Imaging of Knee Osteoarthritis and Acute Knee Injuries
The purpose of this study is to use better magnetic resonance imaging (MRI) techniques to examine the knee and the bony and soft tissue changes so as to better predict the progression of osteoarthritis and acute knee injuries.
- Trial name
- NCT00504114
- Testing
- ACL Reconstruction Surgery, Cartilage Resurfacing Surgery, Total Knee Replacement
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Knee Osteoarthritis
Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty
The total knee arthroplasty (TKA) is a well established option for the treatment of osteoarthritis in this joint. Nevertheless, there are still some concerns related to the peri-operative management of elderly patients…
- Trial name
- NCT02152917
- Testing
- Tranexamic acid, Floseal®
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Greek population?
- Trial name
- NCT04463290
- Testing
- No intervention, Patients selection based on clinical symptoms and radiological imaging
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Knee Osteoarthritis
Effectiveness of Contemporary Knee Arthroplasty in Working-age Patients
The aim of our study was to assess the effectiveness of contemporary knee arthroplasty in working-age patients (< 65 years) by conducting a prospective cohort study with 2-year follow up.
- Trial name
- NCT03233620
- Testing
- Knee arthroplasty
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Coxa, Hospital for Joint Replacement