Clinical trials: OA Knee Pain
Osteoarthritis of the Knee
Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain
This study is being performed to assess the relative effectiveness of genicular nerve ablation with the COOLIEF* Cooled Radiofrequency probe to manage moderate to severe knee pain in patients with osteoarthritis (OA) of the knee…
- Trial name
- NCT04145011
- Testing
- Cooled Radiofrequency, Standard Radiofrequency
- Where
- 7 sites in United States
- Volunteers
- 153 people
- Sponsor
- Avanos Medical
Osteoarthritis of the Knee
Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee
The purpose of this trial is to investigate the efficacy and safety of OLT1177 Gel in subjects with moderate to severe pain associated with osteoarthritis of the knee following cessation of pain therapy.
- Trial name
- NCT01768975
- Testing
- OLT1177 Gel
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Olatec Therapeutics, Inc.
Osteoarthritis
Open-Label Study of Diclofenac Capsules to Treat Osteoarthritis Pain
The purpose of this study is to evaluate the safety of Diclofenac [Test] Capsules for the treatment of osteoarthritis pain of the knee or hip.
- Trial name
- NCT01510912
- Testing
- Diclofenac
- Where
- 40 sites in United States
- Volunteers
- 602 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Pain, Osteoarthritis, Knee
Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee
The purpose of the study is to evaluate the safety and effectiveness of the investigational ketoprofen patch with a controlled heating patch, compared to placebo (inactive substance) for the treatment of pain caused by…
- Trial name
- NCT00108810
- Testing
- Transdermal Ketoprofen Patch with CHADD
- Where
- 5 sites in United States
- Volunteers
- 118 people
- Sponsor
- ZARS Pharma Inc.
Pain, Osteoarthritis
A Study of the Efficacy and Safety of 2PX in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of the study is to demonstrate the superiority of topically administered 2PX versus placebo (vehicle) control in terms of reduction in pain intensity and physical function.
- Trial name
- NCT00954629
- Testing
- strontium chloride hexahydrate
- Where
- 15 sites in Finland, Poland and 2 more
- Volunteers
- 300 people
- Sponsor
- Smerud Medical Research International AS
Osteoarthritis of the Knee
HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain
Ketoprofen in a topical patch formulation has been demonstrated to be effective for treating mild to moderate pain caused by various musculoskeletal disorders.
- Trial name
- NCT00792727
- Testing
- ketoprofen Patch
- Where
- 36 sites in United States
- Volunteers
- 380 people
- Sponsor
- Hisamitsu Pharmaceutical Co., Inc.
Osteo Arthritis Knee
A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the analgesic efficacy of V120083 twice daily compared to placebo in subjects with moderate to severe chronic pain due to OA of the knee.
- Trial name
- NCT03028870
- Testing
- V120083, Naproxen
- Where
- 30 sites in United States
- Volunteers
- 291 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis, Knee
CBD for Knee Osteoarthritis
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population.
- Trial name
- SLACK-OA (NCT06414473)
- Testing
- Cannabidiol (CBD) Extract
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Knee Osteoarthritis, Knee Arthritis
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
This is a prospective, multi-center study, designed to assess mid-term performance of the MOTO Medial® Unicompartmental Knee Arthroplasty (UKA), with patient report outcomes, clinical findings and radiographic analysis.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
- Trial name
- NCT03211663
- Testing
- MOTO Medial® UKA
- Where
- 5 sites in United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Osteoarthritis, Osteo Arthritis Knee
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints
- Trial name
- GARM-MSK-ALD (NCT04238143)
- Testing
- Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Knee Osteoarthritis
Chatbot-based Pain Management for People With Knee Osteoarthritis
Knee osteoarthritis (OA) is a prevalent degenerative joint disease that causes chronic pain, stiffness, impaired physical function, and associated psychosocial issues such as depression, insomnia, and loneliness.
- Trial name
- C-MPPM (NCT07843784)
- Testing
- The C-MPPM intervention, Online education
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- The Hong Kong Polytechnic University
Low Back Pain, Knee Osteoarthritis
Central Sensitization in Patients Seeking Outpatient Physical Therapy Services
This is an observational study to examine presence of CS in patients with knee osteoarthritis (OA), chronic LBP (CLBP), and chronic neck pain (CNP) seeking outpatient physical therapy (PT) services.
- Conditions
- Low Back Pain, Knee Osteoarthritis, Neck Pain
- Trial name
- NCT05467592
- Testing
- Standard Physical Therapy care
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Kansas Medical Center
Pain, Postoperative, Osteoarthritis, Knee
Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin
Evaluation of the analgesic efficacy of a pre-operative dose of ketorolac and gabapentin in reducing post-operative pain scores in patients undergoing TKA
- Trial name
- NCT07047040
- Testing
- Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Assiut University
Knee Osteoarthritis, Knee Injuries
Para-sartorial Compartment Block in Knee Surgery
Selective blockade of the saphenous nerve branches is among the regional anesthesia techniques in knee surgery. In this block, analgesia is provided without motor block and is an essential advantage in terms of early mobilization…
- Conditions
- Knee Osteoarthritis, Knee Injuries, Knee Disease, Knee Arthritis
- Trial name
- NCT05566561
- Testing
- Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Osteoarthritis, Knee, Osteoarthritis of the Knee
Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee
This clinical trial is being done to better understand how daily treatment with Tetrahydrocannabinol (THC), Cannabidiol (CBD), or the combination of CBD plus THC affects knee osteoarthritis pain and other related symptoms.
- Trial name
- NCT04992624
- Testing
- Cannabidiol (CBD), Tetrahydrocannabinol (Marinol® or generic equivalent (e.g., dronabinol)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Steven E Harte, PhD
Knee Osteoarthritis
Low-Dose Radiotherapy for Painful Knee Osteoarthritis
Knee osteoarthritis is a common cause of chronic pain and difficulty with everyday activities, particularly in older adults. Some patients continue to experience clinically relevant knee pain despite medication, therapeutic…
- Trial name
- LDRT-KOA (NCT07886697)
- Testing
- Low-Dose Radiotherapy (LDRT)
- Where
- 4 sites in Spain
- Volunteers
- 283 people
- Sponsor
- Universidad Rey Juan Carlos
Osteoarthritis, Knee
Effect of Transcutaneous Electrostimulation (TENS) on Pain and Physical Function in Patients With Knee Osteoarthritis
The proposed study is a multi-center, randomized, double blind (patient and assessor), sham controlled clinical trial using a parallel 2 group design recruiting 220 patients of at least 18 years of age.
- Trial name
- ETRELKA (NCT01875042)
- Testing
- TENS
- Where
- Switzerland
- Volunteers
- 220 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Severe Osteoarthritis of the Knee
Study of Ampion for the Treatment of Pain and Function in Patients With Severe Osteoarthritis of the Knee.
The purpose of this study is to confirm the safety and efficacy of Ampion for the treatment of pain and function in patients with severe osteoarthritis of the knee.
- Trial name
- NCT03988023
- Testing
- Ampion, Saline
- Where
- United States
- Volunteers
- 1,043 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Knee Osteoarthritis
To Assess the Lanconone® (E-OA-07) Efficacy in Physical Activity-related Pain- LEAP Study
The current study is designed to assess the pain relieving effect of 4-weeks ingestion of this commercialized dietary supplement (Lanconone®, Enovate Biolife, LLC, 1000 mg twice per day) in mild to moderate OA subjects.
- Trial name
- LEAP (NCT03262805)
- Testing
- Lanconone
- Where
- 3 sites in India
- Volunteers
- 73 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis of the Knee
Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial
To compare the effects of perioperative intravenous Dexamethasone with a placebo on the severity of persistent postsurgical pain after total knee arthroplasty.
- Trial name
- NCT02760459
- Testing
- Dexamethasone, Normal saline solution
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Chiang Mai University