Clinical trials: OCD
OCD, Obsessive-Compulsive Disorder
Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE)
The investigators propose to synchronize automated measurements of behavior - head, body, and face dynamics, gaze, and vocal prosody - with simultaneous recordings of brain activity in clinically relevant contexts.
- Trial name
- ABOVE (NCT03459456)
- Testing
- Provocation OC task (Provoc), Trier Social Stress Test (TSST), Exposure provocation task
- Where
- 3 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Generalized Anxiety Disorder
Pilot Study of Virtual Reality for Providing Exposure Therapy to Children
Drs. from the Mayo Clinic Rochester will plan and execute a feasibility study of the phase I prototype version of the Virtual Reality exposure therapy system. Dr.
- Trial name
- NCT03208348
- Testing
- Pilot Virtual Reality
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minnesota HealthSolutions
Obsessive-Compulsive Disorder
Control and Reward Circuits in Obsessive Compulsive Disorder
The purpose of this study is to examine the brain functioning of OCD patients and healthy controls before and after treatment with Exposure and Response Prevention (EXRP) therapy.
- Trial name
- NCT02221518
- Testing
- Exposure & Response Prevention (EX/RP)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Generalized Anxiety Disorder, Major Depressive Disorder
Development of Online EMDR Therapy System and Its Comparative Testing With Face-to-Face EMDR Therapy for Treatment of Anxiety and Depressive Disorders in Pakistan
This study aims at developing an online system for the remote delivery of EMDR therapy in Pakistan. Moreover, this study will compare the efficacy of online EMDR therapy with face-to-face EMDR therapy.
- Conditions
- Generalized Anxiety Disorder, Major Depressive Disorder, Social Anxiety Disorder, Somatic Symptom
- Trial name
- NCT05785312
- Testing
- Online EMDR Therapy System, Face to Face Eye Movement Desensitization & Reprocessing Therapy
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khushal Khan Khattak Univeristy, Karak, Pakistan
Anxiety Disorders, Post Traumatic Stress Disorder
Increasing Treatment Efficacy Using SMART Methods for Personalizing Care
The proposed study will determine the feasibility, tolerability, and acceptability of a study that tests: 1) personalized treatment delivery (i.e., module sequencing and treatment discontinuation timing) aimed at increasing the…
- Conditions
- Anxiety Disorders, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder
- Trial name
- NCT04642898
- Testing
- Standard UP Treatment, Capitalization UP Treatment, Compensation UP Treatment
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shannon E. Sauer-Zavala
Obsessive-Compulsive Disorder
Psychiatric Neurosurgery (PNS) for Obsessive Compulsive Disorder (OCD): A Qualitative Analysis of Patient and Family Member Experiences
In this study the investigators will use semi-structured interviews to qualitatively analyse patient and family member experiences with either deep brain stimulation or other forms of psychiatric neurosurgery.
- Trial name
- NCT02537795
- Testing
- deep brain stimulation, anterior capsulotomy
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obsessive-Compulsive Disorder/High Compulsive Individuals, Healthy Individuals
The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms
The aim of this project is to investigate: The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive behaviour and how it is affected by sub-chronic escitalopram administration The mechanisms underlying…
- Trial name
- NCT04336228
- Testing
- Escitalopram
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obsessive Thoughts
Study of the Efficacy of GGRO: a Novel Cognitive Training App
The aim of the present study was to evaluate the efficacy of GGRO reducing OCD related maladaptive beliefs and OCD symptoms. Specifically, a randomized controlled trial with crossover design was carried out in non-clinical…
- Trial name
- GGRO (NCT03571464)
- Testing
- GGRO Mobile App
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Valencia
OCD
The Imaging Genetic Study of the Core Family of Obsessive-compulsive Disorder (OCD) Patient
To investigate the structural/functional abnormalities and the possible genetic endophenotypes of Obsessive-compulsive disorder (OCD) patients and their core families.
- Trial name
- NCT01298622
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kunming Medical University
Neurotic Disorders, Obsessive-Compulsive Disorder
An Open-Label Study Of Lamictal In Neurotic Excoriation
The goal of the proposed study is to evaluate the efficacy and safety of Lamictal in neurotic excoriation. Twenty subjects with neurotic excoriation will receive 12 weeks of open-label treatment with Lamictal.
- Trial name
- NCT00269594
- Testing
- Lamictal (lamotrigine)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obsessive-Compulsive Disorder
Development of Adaptive Deep Brain Stimulation for OCD (Phase 1a)
This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts…
- Trial name
- NCT03457675
- Testing
- Activa PC+S DBS implant for OCD, One Month Blinded Discontinuation Period
- Where
- 3 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Obsessive-Compulsive Disorder, Microbiota
Microbiome in Obsessive-compulsive Disorder
Background: Humans live in symbiosis with microbes and their implication for health and disease is evident. The importance of microbiome-gut-brain axis in psychiatric disorders is an area of increasing research interest.
- Trial name
- MIO (NCT03638791)
- Testing
- Exposure and response inhibition
- Where
- Sweden
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obsessive-Compulsive Disorder
Cognitive Bias Modification for Thought-Action Fusion
An important cognitive bias in many emotional disorders, particularly obsessive-compulsive disorder (OCD), is thought-action fusion (TAF).
- Trial name
- TAF (NCT03921255)
- Testing
- Cognitive Bias Modification
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Milwaukee
Parkinson's Disease, Obsessive-Compulsive Disorder
Mechanisms of Fronto-Subcortical Dysfunction: Comparing PD and OCD
The purpose of this study is to characterize and compare irregularities in dopaminergic function in fronto-subcortical circuits, between Parkinson's Disease patients (ON and OFF medication) and patients with obsessive-compulsive…
- Trial name
- NCT00790634
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hoarding Disorder, Virtual Reality Based Therapy
Non-Immersive Virtual Environments for the Treatment of Hoarding Disorder
This experimental trial investigates whether Virtual Reality Exposure (VRe) helps individuals reduce the difficulty of discarding personal possessions. It will also evaluate the psychological state impacts of the intervention.
- Conditions
- Hoarding Disorder, Virtual Reality Based Therapy, General Population (no Specific Condition or Disease)
- Trial name
- HD&VR (NCT07160543)
- Testing
- Imagination Exposure, Non-immersive Virtual Reality Exposure
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Padova
Obsessive-Compulsive Disorder, Social Anxiety Disorder
Neurobiological Markers of Treatment Response for Anxiety and OCD
Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided.
- Conditions
- Obsessive-Compulsive Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT05663489
- Testing
- Bergen 4-Day Treatment (B4DT)
- Where
- Norway
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Obsessive-Compulsive Disorder
The Neurocircuitry of Relief During Avoidance Learning in Patients With Obsessive-compulsive Disorder
To investigate the neuro-mechanisms underpinning persistent avoidance in OCD patients
- Trial name
- AvoidOCD (NCT04685018)
- Testing
- fMRI acquisition
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Obsessive Compulsive Disorder
Modification of Cerebral Activity of Obsessive Compulsive Disorder (OCD) Patients During Cognitive and Behavioral Therapy
Obsessive compulsive Disorder (OCD) is a frequent psychiatric disorder. Obsessions and compulsions are the two manifestations of this disease.
- Trial name
- TOC TOC (NCT01331876)
- Testing
- Cognitive and behavioral Therapy
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Depression Disorders, Bipolar Affective Disorder
Epidemiological Study on the Prevalence of Mental Disorders in Slovakia
This study maps the current epidemiological situation of mental disorders in Slovakia. The aim of the study is to determine the prevalence of selected mental disorders in the adult population of the Slovak Republic, assess the…
- Conditions
- Depression Disorders, Bipolar Affective Disorder, Generalized Anxiety Disorder (GAD), Panic Disorder
- Trial name
- EpiMentDisSK (NCT07129408)
- Where
- Slovakia
- Volunteers
- 3,100 people, healthy volunteers welcome
- Sponsor
- Comenius University
Obsessive-Compulsive Disorder
Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD
This study aims to explore the efficacy and influencing of accelerated dTMS (deep Transcranial Magnetic Stimulation) treatment in patients with obsessive-compulsive disorder (OCD), and explores the potential neural mechanisms of…
- Trial name
- NCT06692114
- Testing
- Deep Transcranial Magnetic Stimulation, DTMS active
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zhen Wang