Clinical trials: OSA - Obstructive Sleep Apnea
Myalgia, Apnea, Obstructive Sleep
Temporomandibular Disorder (TMD) Pain in Response to Jaw Advancement in People With TMD and Obstructive Sleep Apnea
The purpose of this study is to characterize the course of temporomandibular disorder (TMD) pain in adults with TMD and obstructive sleep apnea (OSA), all of whom are being treated with mandibular advancement splint (MAS)…
- Trial name
- NCT02685202
- Testing
- Mandibular advancement splint
- Volunteers
- 9 people
- Sponsor
- University of North Carolina, Chapel Hill
Obstructive Sleep Apnea, Pregnancy
Auto-PAP Therapy For Improved Fetal Growth
The purpose of this study is to see whether the presence of night-time breathing disturbances ("sleep-disordered breathing") in pregnant women is related to fetal growth patterns.
- Trial name
- NCT03318003
- Testing
- Auto-PAP
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Michigan
Sleep Apnea, Obstructive
Titration Pressures in Sleep Apnea Patients Using ThermoSmart® Versus Conventional Humidification
Patients who have Obstructive Sleep Apnea (OSA) may have different Continuous Positive Airway Pressure (CPAP)when titrated with different levels of humidification.
- Trial name
- NCT00681083
- Testing
- Heated breathing tube (CPAP with ThermoSmart), Non heated breathing tube (CPAP with conventional humidification)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Fisher and Paykel Healthcare
Sleep-disordered Breathing, Obstructive Sleep Apnea
Comparison of Sleep Study Results After Partial Intracapsular Tonsillectomy Versus Total Tonsillectomy
The purpose of this study is to demonstrate similar improvements in sleep-disordered breathing as determined by sleep study with microdebrider-assisted partial intracapsular tonsillectomy and adenoidectomy versus total Bovie…
- Trial name
- NCT00887471
- Testing
- PITA or T&A
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York - Downstate Medical Center
Obstructive Sleep Apnea
The Impact of Venlafaxine on Apnea Hypopnea Index in Obstructive Sleep Apnea
The investigators hypothesis is that obstructive sleep apnea (OSA) patients with a low arousal threshold may wake up too early during a respiratory event, before upper airway muscles can be activated to achieve stable…
- Trial name
- NCT02714400
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea
Chronic Care Management With Wearable Devices in Patients Prescribed Positive Airway Pressure Therapy (mPAP) Trial
The goal of this clinical trial in adults with obstructive sleep apnea prescribed positive airway pressure therapy is to test the effects of a new patient-facing consumer wearable-based program (that involves provision of a…
- Trial name
- mPAP (NCT06039865)
- Testing
- Immediate Intervention, Waitlist control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Chronic Cough, OSA
Sham CPAP vs. Straight CPAP for Chronic Cough
Chronic cough is an important clinical problem in primary care and sub-specialty practice. Besides the distress experienced by patients with chronic cough, significant healthcare resources are expended to understand the role of…
- Trial name
- NCT03172130
- Testing
- Straight CPAP
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Krishna M. Sundar
Obstructive Sleep Apnea
Lifestyle Modification Program to Treat Obstructive Sleep Apnea Patients
Obstructive sleep apnea syndrome (OSAS) is a common form of sleep-disordered breathing (SDB) characterized by repetitive episodes of cessation of breathing during sleep due to upper airway collapse.
- Trial name
- OSA (NCT01384760)
- Testing
- Lifestyle modification, Simple lifestyle advice
- Where
- China
- Volunteers
- 185 people
- Sponsor
- Chinese University of Hong Kong
Obstructive Sleep Apnea
Effect of Added Varnum Mouthpiece on Pharyngeal Collapsibility and Sleep Apnea Severity in Mouth Breathers.
Test the effect of added a single-use Varnum mouthpiece on pharyngeal collapsibility and obstructive sleep apnea (OSA) severity in patients who identify themselves as mouth breathers.
- Trial name
- NCT02738255
- Testing
- Varnum mouthpiece
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- David Andrew Wellman
Obstructive Sleep Apnea, Coronary Heart Disease
Obstructive Sleep Apnea Treatment to Improve Cardiac Rehabilitation
This is a randomized clinical trial in U.S. Veterans to evaluate the impact of treatment for obstructive sleep apnea (OSA) on the effectiveness of cardiac rehabilitation, including impact on exercise capacity, disability, and…
- Trial name
- NCT02005445
- Testing
- CPAP, HLSE
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Lung Diseases, Sleep Apnea Syndromes
Continuous Positive Airway Pressure to Improve Milder Obstructive Sleep Apnea
The purpose of this study is to determine whether functional status improves in individuals with milder obstructive sleep apnea (OSA) following continuous positive airway pressure (CPAP) treatment.
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Hypertension
- Trial name
- CATNAP (NCT00089752)
- Testing
- Continuous Positive Airway Pressure (CPAP) Treatment
- Where
- 5 sites in United States, Canada
- Volunteers
- 281 people
- Sponsor
- University of Pennsylvania
Sleep Apnea
A Novel Pharmacological Therapy for Obstructive Sleep Apnea
A pharmacological, non-mechanical therapy for OSA that is efficacious and tolerable remains elusive. Here the investigators study the effect on sleep apnea severity of a combination of pharmacological agents (atomoxetine and…
- Trial name
- NCT03919955
- Testing
- Atomoxetine, Oxybutynin
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea, Tonsillitis
Pediatric Pain Optimization After Tonsillectomy
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.
- Conditions
- Obstructive Sleep Apnea, Tonsillitis, Pain, Procedural
- Trial name
- NCT05244226
- Testing
- Fentanyl/Hydromorphone, Methadone
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Obstructive Sleep Apnea, Overweight
Influence of Exercise, Weight Loss, and Exercise Plus Weight Loss on Sleep Apnea
Obstructive sleep apnea (OSA) is highly prevalent among Veterans, and is associated with significant mortality and multiple morbidities.
- Trial name
- NCT02721251
- Testing
- Exercise, Weight Loss, Exercise + Weight Loss
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Apnea, Sleep
Radiofrequency Ablation for Multi-level Obstructive Sleep Apnea: A Single-arm, Multicenter Study
The United States is currently experiencing an increase in the incidence and prevalence of obstructive sleep apnea (OSA). With prevalence in middle-aged adults of 2 to 4% of the population, untreated OSA has been implicated in…
- Trial name
- NCT02349893
- Testing
- RFA treatment
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- Olympus Surgical Technologies Europe
Sleep Apnea, Diabetes
Hyperglycemic Profiles in Obstructive Sleep Apnea: Effects of PAP Therapy
This is a randomized control trial in people with diabetes and obstructive sleep apnea who will be randomly assigned for 3 months to PAP therapy along with healthy lifestyle and sleep education or healthy lifestyle and sleep…
- Trial name
- HYPNOS (NCT02454153)
- Testing
- REMStar Positive Airway Pressure, LifeStyle Counseling
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Johns Hopkins University
Sleep Apnea - Obstructive, Cost Effectiveness
Remote Diagnosis and Management of Obstructive Sleep Apnea
Although obstructive sleep apnea, a breathing disorder during sleep, is prevalent and recognized as a major public health concern, most Veterans with this disorder are undiagnosed and therefore untreated.
- Conditions
- Sleep Apnea - Obstructive, Cost Effectiveness, Telemedicine
- Trial name
- NCT03007745
- Testing
- autoadjusting continuous positive airway pressure
- Where
- 3 sites in United States
- Volunteers
- 435 people
- Sponsor
- VA Office of Research and Development
Obstructive Sleep Apnea
Adherence Risk Indicator Validation Study
While continuous positive airway pressure (CPAP) is the gold standard treatment of obstructive sleep apnea (OSA), this therapy is often discontinued or not used optimally.
- Trial name
- ARI (NCT02230085)
- Testing
- Administration of the questionnaire and monitoring of CPAP adherence
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Comparison Study of the ICON™ CPAP Series With and Without SensAwake™
Conceptually, awareness of pressure occurs only during wakefulness. Thus reducing the pressure during wakefulness may improve therapy comfort and potentially adherence without compromizing therapy efficacy.
- Trial name
- NCT01831258
- Testing
- SensAwake On, SensAwake Off
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Study to Assess the Changes in Blood Clotting Factors and Blood Vessel Wall Function in Obstructive Sleep Apnea
Obstructive sleep apnea is a condition in which people have decreased breathing during their sleep. Untreated sleep apnea has been linked to increased risk for cardiovascular diseases.
- Trial name
- NCT00936481
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University