Clinical trials: OSCC
Oral Squamous Cell Carcinoma
Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma
The research and development of novel anti-tumor agents in oral cancer is slow, the investigation of repositioning use of currently available drugs in clinical, such as a selective cyclooxygenase-2 (COX-2) inhibitor…
- Trial name
- NCT02739204
- Testing
- Celecoxib
- Where
- Taiwan
- Volunteers
- 270 people
- Sponsor
- China Medical University Hospital
Oral Cavity Squamous Cell Carcinoma
Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC)
This is a study of oral nisin administration in patients with OSCC who are undergoing complete surgical resection surgery with or without adjuvant radiation/chemoradiation as part of their routine care at the University of…
- Trial name
- NCT06097468
- Testing
- NisinZ® P, Surgery (non-interventional, standard of care)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder
NBI for Early Diagnosis of OPMD/OSCC
Early detection - possibly at its pre-malignant stages (Oral Potentially Malignant Disorders, OPMD) - with periodic surveillance is thus fundamental for limiting disease burden, hopefully reducing the incidence of advanced stages…
- Trial name
- NBI_Oral (NCT06438939)
- Testing
- Biopsy for diagnostical purposes
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- Cardarelli Hospital
Oral Cancer
The Oral Microbiome in OSCC
Previous work by a number of scientific teams has revealed that the types of bacteria that colonize the mouth differ between health and pre-cancerous or cancerous oral lesions.
- Trial name
- NCT04925700
- Testing
- ProDentis Lozenge
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Oral Squamous Cell Carcinoma (OSCC)
A Dye for the Detection of Cancer of the Tongue and Mouth
The purpose of this study is to test if an investigational dye, called PARPi-FL, can be used to detect this type of cancer. This will be the first time that PARPi-FL is being tried in people.
- Trial name
- NCT03085147
- Testing
- Olaparib
- Where
- 7 sites in United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Oral Cavity Squamous Cell Carcinoma
Feasibility of CTCs Isolation for Transcriptomes and Genome Wide Associated Analysis in Post-OP High Risk OSCC Patients.
Anti-cancer treatments have been thought to be closely related to their unique genetic alterations. In the past few years, the investigator have used cDNA microarray to delineate the transcriptome profiles of…
- Trial name
- CTC (NCT03917524)
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Oral Squamous Cell Carcinoma (OSCC), Premalignant Lesion
Comparison of TLC (Total Leucocyte Count), Neutrophils and Monocytes in Oral Squamous Cell Carcinoma and Pre-malignant Disorders
Oral squamous cell carcinoma is one of the significant public health concerns and the most prevalent malignancies affecting the head and neck region globally.
- Trial name
- NCT07899255
- Testing
- CBC will be required to assess the level of TLC (Total Leucocyte Count), Neutrophils and Monocytes in patient of oral squamous cell carcinoma and oral pre malignant conditions, using different stains
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Dow University of Health Sciences
Oral Squamous Cell Carcinoma (OSCC), Oropharyngeal Squamous Cell Carcinoma
Neoadjuvant and Adjuvant Sintilimab Plus Cetuximab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma
The purpose of this study is to evaluate the effectiveness and safety of the combination therapy of immunotherapy (Sintilimab) with targeted therapy (Cetuximab) as a possible treatment before and after surgery for locally…
- Conditions
- Oral Squamous Cell Carcinoma (OSCC), Oropharyngeal Squamous Cell Carcinoma, Resectable Oral and Oropharyngeal Squamous Cell Carcinoma
- Trial name
- OSCC (NCT07079410)
- Testing
- Sintilimab+Cetuximab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Oral Squamous Cell Carcinoma
Association of Salivary Amino Acid Level With OSCC Identified By Liquid Chromatography Mass Spectroscopy
Oral Squamous Cell Carcinoma (OSCC) is the most common oral malignancy worldwide. The prognosis of the OSCC patient is not significant despite the modern treatment facilities.
- Trial name
- OSCC (NCT05150509)
- Testing
- Oral Squamous Cell Carcinoma
- Where
- 2 sites in Bangladesh
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- DR. MALA KHAN
Oral Squamous Cell Carcinoma (OSCC), Diagnosis
Trop2-targeting NIR-II Molecular Probe for Precision Diagnosis of Oral Cancer
Given the morphological and clinical similarities between certain oral malignant neoplasms and benign conditions such as oral ulcerations or inflammatory lesions, the potential for misdiagnosis is significant.
- Trial name
- NCT07794813
- Testing
- TTP-ICG incubation solution
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yunnan Cancer Hospital
Oral Squamous Cell Carcinoma (OSCC)
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
This observational study will evaluate whether salivary interleukin-6 levels and selected interleukin gene polymorphisms are associated with regional lymph node involvement in patients with oral squamous cell carcinoma.
- Trial name
- IL6-OSCC (NCT07692360)
- Testing
- Saliva Collection and Biomarker Analysis
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- University of Pavia
Oral Cancer
A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma
Surgical resection followed by concurrent chemoradiotherapy is considered as the standard of care for locally advanced OSCC (LAOSCC).
- Trial name
- NCT00933387
- Testing
- Cetuximab,Paclitaxel,Cisplatin
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- National Health Research Institutes, Taiwan
Oral Squamous Cell Carcinoma (OSCC)
Evaluation of the Efficacy and Safety of Nivolumab Neoadjuvant Treatment of Patients With Locally Advanced Oral Squamous Cell Carcinoma
This is a Phase II, single-centre, non-randomized, single-arm clinical trial to investigate the efficacy and safety of neoadjuvant nivolumab therapy in adult participants with resectable, locoregionally advanced Oral Squamous…
- Trial name
- NOCANO (NCT07514767)
- Testing
- Nivolumab (240 mg)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Prof. Lars Olaf Cardell
Oral Cancer, Oral Cavity Cancer
Effectiveness of Opioid vs Pregabalin Plus Naproxen Sodium in Pain Management of Oral Cancer Patients
This randomized clinical study was designed to compare two pain treatment approaches for adults with oral cancer who had moderate to severe pain.
- Conditions
- Oral Cancer, Oral Cavity Cancer, Oral Squamous Cell Carcinoma (OSCC)
- Trial name
- NCT07606638
- Testing
- Tramadol, Pregabalin + Naproxen Sodium
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Mayo Hospital Lahore
Mouth Neoplasms, Carcinoma, Squamous Cell
GDF15 Based TPF Induction Chemotherapy for OSCC Patients
The purpose of this study is to confirm the predictive value of GDF15 expression for TPF induction in T3/T4cN0M0 patients with OSCC
- Trial name
- NCT02285530
- Testing
- TPF induction chemotherapy, surgery group, Post-operative radiotherapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Oral Squamous Cell Carcinoma (OSCC)
Clinical Outcomes of Thoracodorsal Artery Flap in Oral and Maxillofacial Reconstruction
The goal of this study is to retrospectively compare different types of free flaps to determine the most suitable free flap for functional reconstruction in oral squamous cell carcinoma patients following tumor resection.
- Trial name
- NCT06599801
- Testing
- Thoracodorsal artery perforator flap reconstruction surgery, Forearm flaps reconstruction surgery, Anterolateral thigh flap reconstruction surgery
- Where
- China
- Volunteers
- 217 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Oral Squamous Cell Carcinoma, Neoadjvant Therapy
Neoadjuvant Personalized Anti-PD-1 and Anti-VEGFR Therapy in OSCC Patients
To evaluate the efficacy of neoadjuvant anti-PD-1 plus anti-VEGFR therapy for patients with locally advanced and resectable oral squamous cell carcinoma, and the CPS>10 in the biopsy samples.
- Conditions
- Oral Squamous Cell Carcinoma, Neoadjvant Therapy, Anti-PD-1, Anti-VEGFR
- Trial name
- NCT05069857
- Testing
- Camrelizumab (anti-PD-1 inhibitor), Apatinib (anti-VEGFR inhibitor)
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Tongue Neoplasms, Carcinoma
Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line
In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than…
- Trial name
- NCT03288298
- Testing
- luteolin, nano-luteolin
- Volunteers
- 4 people
- Sponsor
- Cairo University
Oral Squamous Cell Carcinoma, Neoadjvant Therapy
Neoadjuvant Anti-PD-1 and TP Versus TPF on Pathological Response in OSCC
To compare the pathological efficacy of neoadjuvant Toripalimab and Albumin paclitaxel /Cisplatin (TTP) with Docetaxel/ Cisplatin/ 5-flurouracil (TPF) for patients with locally advanced resectable oral squamous cell carcinoma…
- Conditions
- Oral Squamous Cell Carcinoma, Neoadjvant Therapy, Anti-PD-1, Chemotherapy
- Trial name
- NCT05125055
- Testing
- Toripalimab (anti-programmed death-1 inhibitor), Albumin paclitaxel, Cisplatin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Oral Squamous Cell Carcinoma (OSCC)
Immunohistochemical Expression of Cyclin D1 in Oral Squamous Cell Carcinoma: Relationship With Clinicodemographic and Histopathological Features
Oral squamous cell carcinoma is a major public health problem , especially in West Asian countries. Cyclin D1 accelerates cell cycle and thus may be implicated in uncontrolled cellular proliferation and tumor progression.
- Trial name
- NCT07778615
- Testing
- immunohistochemical expression of Cyclin D1 on oral squamous cell carcinoma tissue sections
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Sohag University