Clinical trials: Obese Adults
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight or Obese Adults, Overweight or Obese, Type 2 Diabetes
Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants With or Without T2D
A Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants with or without Type 2 Diabetes
- Trial name
- NCT07399678
- Testing
- ALV-100
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Alveus Therapeutics, Inc.
Sleeve, Postoperative Pain
Analgesia After Endoscopic Sleeve Gastroplasty
Endoscopic sleeve gastroplasty (ESG) is a new mini-invasive technique proposed to treat obesity (1-5). According to the endoscopic procedure compared to videolaparoscopy, this technique is supposed less painful and provide a…
- Conditions
- Sleeve, Postoperative Pain, Obese Adult Male
- Trial name
- pain & Sleeve (NCT07875283)
- Testing
- Postoperative analgesia
- Where
- France
- Volunteers
- 100 people
- Sponsor
- American Hospital of Paris
Obese, Overweight Adults
A Clinical Trial to Investigate the Safety and Efficacy of MB-1 on Metabolic Health in Overweight and Obese Adults
The goal of this clinical trial is to investigate the safety and efficacy of MB-1 on metabolic health in overweight and obese adults.
- Conditions
- Obese, Overweight Adults, Obese Adults, Body Weight Control
- Trial name
- NCT07363148
- Testing
- MB-1
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Arrae
Obese Adults
A Phase 1 Study of VK3019 in Overweight and Obese Adults Without Comorbidities
This is a Phase 1, randomized, double-blind, placebo-controlled single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of VK3019 in overweight and obese adults without…
- Trial name
- NCT07846033
- Testing
- SC VK3019
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Viking Therapeutics, Inc.
Postprandial Glycemic Control, Prediabetic Overweight and Obese Adults
A Two-part Study of Lembas Edge Evaluating Tolerability and Postprandial Glycemic Control
The goal of part 1 of this clinical trial is to investigate the tolerability of Lembas Edge in healthy adults. The objective of Part 2 of this study is to investigate the efficacy of Lembas Edge on postprandial glycemic control…
- Trial name
- NCT07711288
- Testing
- Low dose alpha-galactosidase-derived peptide, Medium dose alpha-galactosidase-derived peptide, High dose alpha-galactosidase-derived peptide
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Lembas
Obese Adults
A Phase 1 Study of VK2735 in Obese Adults Without Comorbidities
The goal of this Phase 1, randomized, double-blind, placebo-controlled study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of VK2735 in adults who are obese (BMI ≥ 30 kg/m2) without comorbidities.
- Trial name
- NCT07838740
- Testing
- VK2735 Drug
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- Viking Therapeutics, Inc.
Type 2 Diabetes, Overweight and Obese Adults
Plant-Based Online Weight Loss Through Education and Resources Program and Study
This is an interventional study that will evaluate the feasibility, implementation, and efficacy of an online, 12-week, plant-based, nutrition education program in a community setting.
- Trial name
- POWER (NCT07095543)
- Testing
- Low-fat, vegan diet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Physicians Committee for Responsible Medicine
Overweight and Obese Adults
Exercise Methods for Overweight and Obese Individuals
Obesity is a complex disease and a major risk factor for cardiovascular and metabolic disorders, particularly atherosclerosis, type II diabetes, and metabolic syndrome; it is also associated with an increased risk of mortality.
- Trial name
- NCT07811596
- Testing
- High-Intensity Interval Training (HIIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Obese Adults
Adherence and Quality of Life Across Three Different Intermittent Fasting Protocols in Obese Working Women
In these recent years, Intermittent Fasting (IF) has become popular among the public and health fraternities not only because it produced evidence-based results as an alternative dietary approach in weight loss strategy, but also…
- Trial name
- IF (NCT07804329)
- Testing
- Adherence to the IF Protocol, Quality of Life
- Where
- Malaysia
- Volunteers
- 32 people
- Sponsor
- Suriana Md Akir
Overweight and Obese Adults
Behavioral Weight Loss and Sleep Health Intervention
This is a 6-month single-arm pilot and feasibility study designed to examine if a behavioral weight loss (BWL) intervention with an added sleep health program (BWL+SLEEP) can achieve clinically meaningful weight loss and…
- Trial name
- DREAM (NCT07255287)
- Testing
- BWL+Sleep
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Colorado, Denver
Overweight and Obese, Young Adult
Effects of Kettlebell Swing Training Combined With Breathing Exercises on Respiratory Muscle Strength and Pulmonary Function in Overweight and Obese Young Adults
Overweight and obesity are associated with impaired breathing mechanics, including reduced chest wall and diaphragmatic movement, decreased respiratory muscle strength and endurance, and inefficient breathing patterns.
- Trial name
- Kettlebell (NCT07802080)
- Testing
- Kettlebell swing training, Control
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Phayao
Overweight and Obese Adults, High Intensity Interval Exercise (HIIE)
Acute Effects of Isoenergetic HIIE vs. MICE on Key Parameters of Fat Mass Loss in Young Females With Overweight or Obesity
Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases.
- Trial name
- COMEFIT (NCT06868862)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Healthy, Overweight and Obese Adults
A Study of SYNT-101 to Test Safety, Tolerability and Pharmacodynamics of SYNT-101 in Healthy and Overweight Adults
A Phase 1, single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacodynamics of single and multiple dose regimens of SYNT-101 in healthy and overweight adults.
- Trial name
- NCT07307274
- Testing
- SYNT101
- Where
- Australia
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Syntis Bio
Overweight or Obese Adults
Time-Restricted Eating for Weight-Loss Maintenance
Weight regain after intentional short-term weight loss is a common challenge. It often undermines the long-term benefits of obesity treatment.
- Trial name
- NCT07163455
- Testing
- Scheduled Weight Maintenance Nutrition Education, Time-Restricted Eating (10-Hour Window)
- Where
- 10 sites in China
- Volunteers
- 500 people
- Sponsor
- Harbin Medical University
Overweight and Obese Adults, BMI>=23 kg/m2
Role of Leucine on Muscle Preservation During Weight Loss in Older Men
Overweight and obesity are part of a global health epidemic. However, older adults trying to lose weight face a dual challenge: first, muscle mass and strength naturally decline at an accelerating rate with age; second, effective…
- Trial name
- NCT07781410
- Testing
- Protein, Leucine
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- Nanyang Technological University
Overweight and Obese Adults
Effects of Obesity on Autophagy and mTORC1 Signalling in Skeletal Muscle
It is well known that individuals living with overweight or obesity are not able to activate skeletal muscle growth processes to the same extent as lean individuals following activities such as weightlifting (resistance exercise)…
- Trial name
- NCT07774676
- Testing
- Skeletal muscle biopsy, venous blood sampling, Protein-Rich Beverage
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Overweight and Obese Adults, BMI >= 23
Dose Response of Leucine on Muscle Maintenance During Weight Loss
The objective of this research is to determine if there is dose response of leucine on muscle maintenance during 4-week of alternate-day fasting (ADF) on blood parameters, body composition, mood and parameters related to appetite…
- Trial name
- NCT07583875
- Testing
- leucine
- Where
- Singapore
- Volunteers
- 92 people
- Sponsor
- Nanyang Technological University
Healthy Participants Study, Overweight and Obese Adults
A Single and Multiple Ascending Dose Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP6590 in Participants With Normal Weight, Overweight and Obesity
The goal of this clinical trial is to learn about the safety and tolerability of drug ZP6590 and to learn how the body processes the drug ZP6590 in adults.
- Conditions
- Healthy Participants Study, Overweight and Obese Adults, First in Man Study to Evaluate Initial Safety
- Trial name
- NCT07721597
- Testing
- ZP6590, solution for injection
- Where
- Germany
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Zealand Pharma
Obese Adults, BMI/Body Composition
Precision Lifestyle Medicine Program for IFHAS Participants
The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who…
- Conditions
- Obese Adults, BMI/Body Composition, Cardiometabolic Risk, Cardiovascular Disease Risk
- Trial name
- NCT07742917
- Testing
- Precision Lifestyle Medicine Program, Standard IFHAS Care
- Where
- United Arab Emirates
- Volunteers
- 150 people
- Sponsor
- Institute for Healthier Living Abu Dhabi