Clinical trials: Obese Diabetics
Type 2 Diabetes, Diabetes Mellitus, Type 2
Comparative Bioavailability - Gender Effect - Single and Multiple Ascending Dose Safety and Pharmacokinetic Study of GFT505
The Sponsor, Genfit, has developed a new formulation of GFT505 (60 mg). The objective is to compare the relative bioavailability between the new GFT505 formulation (capsule dosed at 60 mg GFT505) and the old GFT505 formulation…
- Conditions
- Type 2 Diabetes, Diabetes Mellitus, Type 2, Metabolic Diseases, Cardiovascular Diseases
- Trial name
- NCT01474161
- Testing
- GFT505 120mg - old formulation, GFT505 120mg - new formulation, GFT505 180mg - new formulation
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Genfit
Obesity; Endocrine, Diabete Type 2
Molecular, Metabolomic and Nutritional Changes After Metabolic Surgery
Obesity is a major risk factor for Type 2 Diabetes (T2D) and cardiovascular diseases, such as hypertension and dyslipidemia. Recently, weight loss surgery (i.e., metabolic or bariatric surgery) has been shown to result in very…
- Conditions
- Obesity; Endocrine, Diabete Type 2, PreDiabetes
- Trial name
- MoMen (NCT05322551)
- Where
- Malaysia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Malaysia
Diabetes, Liver
Foxtail Millet Based Dietary Intervention for Postprandial Glycemic Management Among Obese Diabetic Patients
This randomized controlled trial evaluated the effectiveness of foxtail millet (Setaria italica (L.) P. Beauv.) muffin supplementation on postprandial glycemic management among obese patients with type 2 diabetes mellitus.
- Conditions
- Diabetes, Liver, Lipid Profiles
- Trial name
- NCT07699250
- Testing
- T0, T1, T2
- Where
- Pakistan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Obesity, Pre-diabetic
Personalized Glucose Optimization Through Nutritional Intervention
Maintaining well-controlled blood glucose concentrations is essential in the prevention of chronic cardiometabolic diseases. The blood glucose response to dietary and/or lifestyle patterns may vary between individuals.
- Conditions
- Obesity, Pre-diabetic, Type 2 Diabetes Mellitus
- Trial name
- PERSON (NCT03708419)
- Testing
- Optimal diet, Suboptimal diet
- Where
- 2 sites in Netherlands
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Liver Biomarkers, Glucose
Modulatory Effects of Resveratrol Supplement Along With and Without Low Glycemic Index Diet Among Obese Patients With Diabetic Nephropathy
This 12-week randomized controlled trial evaluated the effects of resveratrol supplementation with and without a low glycemic index (LGI) diet in obese patients with diabetic nephropathy.
- Conditions
- Liver Biomarkers, Glucose, Lipid Profiles
- Trial name
- NCT07891975
- Testing
- T0 starch capsule, T1 resveratrol capsule, T2 300 mg per day along with a low glycemic index diet, TWICE A DAY
- Where
- Pakistan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Diabetes Mellitus, Type 2, Diabetic Nephropathy
Molecular and Clinical Profile of Diabetes Mellitus and Its Complications
Background: Family and twin studies have suggested that genetic factors influence approximately 50 percent of a person's susceptibility to type 2 diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Nephropathy, Obesity
- Trial name
- NCT01105858
- Where
- United States
- Volunteers
- 2,310 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Diabetes
Effects of High-Dose Resveratrol in Non-Diabetic Obese Males
The primary aim of our study was to examine the effects of two weeks of oral resveratrol on resting energy expenditure and insulin sensitivity in non-diabetic obese male subjects.
- Trial name
- NCT02247596
- Testing
- Resveratrol
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Khoo Teck Puat Hospital
Obesity, Pregnancy in Diabetic
Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes
The obesity epidemic is growing worldwide and in the UK this is perpetuated with a third of women classified as overweight/obese in 2020.
- Conditions
- Obesity, Pregnancy in Diabetic, Pregnancy Complications, Pregnancy Related
- Trial name
- NCT05753124
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Obesity, Insulin Resistance
The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
The primary aim of this study is to evaluate the effect of exenatide on daily glycemic excursions obtained by continuous glucose monitoring system (CGMS).
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00845559
- Testing
- Exenatide
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Lean, Obese
In Vivo Leptin Signaling in Humans After Acute Leptin Administration
The purpose of this research study is to help us to better understand how leptin regulates blood sugar levels. Leptin is a recently discovered hormone, which is made in fat cells.
- Conditions
- Lean, Obese, Obese Diabetics
- Trial name
- NCT01275053
- Testing
- leptin
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity, Dapagliflozin Adverse Reaction
The Effect of Dapagliflozin on Weight Loss in Obese Adults Without Diabetes
The goal of this clinical trial is to examine the effectiveness of a drug named dapagliflozin (tested drug) on weight loss in young adults aged between 18 and 40 years with obesity who are not diagnosed with diabetes.
- Conditions
- Obesity, Dapagliflozin Adverse Reaction, Weight Loss, Effect of Drug
- Trial name
- DAPA-ANDO (NCT06000462)
- Testing
- Dapagliflozin 10mg Tab, Metformin 1000 mg (ttd)
- Where
- Oman
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oman Ministry of Health
Insulin Resistance, Obesity
Effect of Korean Red Ginseng on Insulin Sensitivity in Non Diabetic Overweight Korean Adults
Korean red ginseng (KRG) is popular worldwide since it is believed to contain ingredients with a variety of health enhancement effects.
- Trial name
- KRGIS (NCT01616134)
- Testing
- Korea red ginseng
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Korean Society of Ginseng
Metabolism and Nutrition Disorder, Obesity
A Trial to Assess the Effect of Liraglutide on Gastric Emptying in Healthy Obese Volunteers
This trial is conducted in Europe. The aim of this clinical trial is to investigate the effect of liraglutide on gastric emptying, energy expenditure and appetite, and to evaluate liraglutide pharmacokinetics in non-diabetic…
- Trial name
- NCT00978393
- Testing
- liraglutide
- Where
- Netherlands
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2, Prediabetic State
Serum Sphingolipidomic Analyses in Healthy, Diabetic and Prediabetic Subjects
This study is designed to compare the serum sphingolipidomic analyses in healthy, pre-diabetic and diabetic subjects. age, sex and BMI are matched among these three groups.
- Trial name
- NCT02826759
- Testing
- diabetes
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Type 2 Diabetes, Obesity
Lifestyle Intervention in Obese Non-diabetic Adults With a Family History of Diabetes.
The aim of this study is to investigate weather gradual weight loss achieved with healthy lifestyle changes influence hormonal factors affecting appetite and blood glucose control in obese people without presence of diabetes.
- Trial name
- NCT00993603
- Testing
- 8-month group lifestyle programme
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Royal Bournemouth Hospital
Diabete Type 2, Obesity
Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals.
The study aims to investigate the impact of Soleus Push Ups (SPU) on Soleus Muscle endurance, Oxidative Stress Markers, Inflammatory markers and Adipocytokines among people in the United Arab Emirates.
- Conditions
- Diabete Type 2, Obesity, Overweight
- Trial name
- NCT06450847
- Testing
- Soleus Muscle Push Up Exercise, Other Exercise
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Gingivitis, Diabetes
Mechanical-chemical Gingival Therapy in Diabetics and/or Obese
Diabetes and obesity affect many people in different countries. Similarly, millions of people have some type of gum disease such as gingivitis.
- Conditions
- Gingivitis, Diabetes, Obesity
- Trial name
- MCGTDO (NCT02123563)
- Testing
- Ultrason Essential oils rinse
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Serum and Corporal Irisin in Diabetic Patients With Erectile Dysfunction
Serum and Corporal Irisin Level and Its Correlation With Erectile Function in Diabetic Obese Patients
Obese and diabetic men constitute a huge fraction of ED patients. There is established relation between both obesity ,diabetes and ED through multiple neuroendocrine and vascular players .
- Trial name
- NCT06696599
- Testing
- Serum and corporal irisin
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypertension, Obesity
Pleiotropic Effects of Azilsartan Medoxomil Over Insulin Resistance in Obese, Diabetic and Hypertensive Patients
The goal of this study is to build a mathematical model to explain the effect of two doses of azilsartan (40 and 80 mg) upon metabolic (insulin resistance, glucose) and inflammatory parameters (cytokines) in function of…
- Conditions
- Hypertension, Obesity, Type 2 Diabetes Mellitus
- Trial name
- NCT02235519
- Testing
- Azilsartan 40 mg., Azilsartan 80 mg
- Where
- Mexico
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Hypertension, Diabete Type 2
Pharmacists Interventions on Patients Diabetic, and Obese Patients in the UAE: Randomized Controlled Trials.
Hypertension, diabetes, and obesity are considered major risk factors for cardiovascular diseases and premature mortality worldwide. Furthermore, they have severe consequences on quality of life among patients.
- Conditions
- Hypertension, Diabete Type 2, Obesity, Pharmacist-Patient Relations
- Trial name
- NCT05488002
- Testing
- Pharmaceutical intervention
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University of Sharjah