Clinical trials: Obese Diabetics
Diabetes Mellitus, Type 2, Obesity
Efficacy of mHealth Apps for Health in a Low-income, Type II Diabetic, Hispanic Population
The purpose of this study is to determine the effectiveness of mobile health applications in improving health outcomes and the subsequent benefit of improving type II diabetes outcomes in a low socioeconomic Hispanic population.
- Trial name
- NCT05279729
- Testing
- Mobile health application
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Diabetes Mellitus, Type 2, Obesity
L-arginine and Asymmetric Dimethylarginine (ADMA) and Lifestyle Protocols
Low serum L-arginine (Arg) and high asymmetric dimethylarginine (ADMA) can predict microvascular complications in type 2 diabetes (T2DM).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Arginine, Asymmetric Dimethylarginine
- Trial name
- NCT04406402
- Testing
- Acute dietary protocols and lifestyle modification
- Where
- Israel
- Volunteers
- 243 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Negative Pressure Therapy, Wound
Nutritional Regulation of Wound Inflammation: Part III
The purpose of this study is to examine the changes that result in the wound healing of a type II Diabetic using Negative Pressure Therapy after 12 weeks of daily supplementation of ImmunAge (Fermented Papaya Preparation (FPP).
- Conditions
- Negative Pressure Therapy, Wound, Open Wound, Type II Obese Diabetic
- Trial name
- FPP3 (NCT02332993)
- Testing
- FPP
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Ohio State University
Prediabetic State
Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects
Branching chain amino acids (BCAA) have both beneficial and detrimental effects of on metabolism have been established and therefore warrants further investigation.
- Trial name
- BCAA (NCT02684565)
- Testing
- BCAA High Protein supplement, BCAA Low Protein supplement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, Los Angeles
Obesity, Type 2 Diabetes
Breast Milk and Infant Growth Among Lean, Overweight and Diabetic Mothers
Childhood obesity is a critical global public health concern. Breastfeeding is the ideal choice for infant nutrition. However, rapid and excess weight gain during infancy predicts later, even among breastfed infants.
- Conditions
- Obesity, Type 2 Diabetes, Gestational Diabetes
- Trial name
- MIG (NCT01693406)
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Obesity
Safety and Efficacy of EndoBarrier in Subjects With Type 2 Diabetes Who Are Obese
To determine if the EndoBarrier safely and effectively improves glycemic control in obese subjects with type 2 diabetes
- Trial name
- ENDO (NCT01728116)
- Testing
- EndoBarrier
- Where
- 25 sites in United States
- Volunteers
- 325 people
- Sponsor
- Morphic Medical Inc.
Obese, Diabetes Mellitus, Type 2
Investigating Effects of BOTOX on Weight Loss and Glucose Tolerance in Obese, Type 2 Diabetic Subjects
The investigators will recruit obese subjects with pre-diabetes or type 2 diabetes for the proposed clinical study for 5 visits.
- Trial name
- NCT03991299
- Testing
- Botox 200 UNT Injection
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes, Interleukins
Randomized Controlled Trial of Laparoscopic Gastric Bypass Plus Omentectomy Versus Laparoscopic Gastric Bypass Alone in Improving Diabetic Indices
To see if removing the omentum in addition to a gastric bypass improves diabetes is better than just a gastric bypass.
- Conditions
- Diabetes, Interleukins, Cytokines
- Trial name
- NCT00552942
- Testing
- laparoscopic gastric bypass plus omentectomy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Legacy Health System
Glucose Intolerance, Obesity
Identification of Predictors of Success for Lifestyle Modifications in Overweight Pre-diabetic Subjects
The primary objective of the study is to identify baseline and early predictors of favorable and unfavorable response to lifestyle intervention.
- Trial name
- NCT00969007
- Testing
- Lifestyle modification counselling
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- Marie-France Langlois
Obesity, Diabetes Mellitus, Type 2
A Study of the Efficacy and Safety of Topiramate in Obese, Type 2 Diabetic Patients Inadequately Controlled on Sulfonylurea Therapy
The purpose of this study is to compare the effectiveness and safety of topiramate with placebo in the treatment of obesity and Type 2 diabetes mellitus in patients who have failed on sulfonylurea therapy.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
- Trial name
- NCT00231634
- Testing
- topiramate
- Volunteers
- 31 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obesity, Overweight
The Influence of Physical Activity on the Gut Microbiome of Pre-Diabetic Adults
The present study is a 100-participant randomized controlled 2-arm parallel trial that employs a metagenomic approach to examine how 8 weeks of supervised moderate-intensity treadmill walking exercise (MWE) for 30-45 min 3…
- Conditions
- Obesity, Overweight, Overweight and Obesity, PreDiabetes
- Trial name
- NCT04931836
- Testing
- Physical Activity Intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Minnesota
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE™ - Obesity and Pre-diabetes
This trial is conducted in Africa, Asia, Europe, Oceania, North America and South America. The aim of this clinical trial is to evaluate the potential of liraglutide to induce and maintain weight loss over 56 weeks in obese…
- Trial name
- NCT01272219
- Testing
- liraglutide
- Where
- 226 sites in United States, Argentina and 27 more
- Volunteers
- 3,731 people
- Sponsor
- Novo Nordisk A/S
Diabetic Kidney Disease, Obesity
Metabolic Phenotypes of Obesity and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus
1. Comparison between the 4 groups of metabolic phenotypes of obesity as regard the presence and frequency of DKD 2. Relation between DKD , obesity (BMI) and metabolic risk factors in patients with type 2 DM
- Conditions
- Diabetic Kidney Disease, Obesity, Metabolic Syndrome, Diabetes Mellitus, Type 2
- Trial name
- NCT06591104
- Testing
- 24 hour urinary protein
- Volunteers
- 71 people
- Sponsor
- Assiut University
Type 2 Diabetes
The Effect of Vitamin D Supplementation on Glucose Metabolism in Non-Diabetic African American Adults
Type 2 diabetes is more common among African Americans than Caucasians. African Americans are also at a higher risk for lower levels of vitamin D compared to other ethnic groups.
- Trial name
- AVIS (NCT01141192)
- Testing
- vitamin D3, cholecalciferol, Inactive comparator
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Augusta University
Glucose Variability
Glucose Variability
A retrospective data review of 243 pregnant women (≤32 wks gestational age), dtat collected prior to 5/18/2014, with GDM, or T2DM, and their infants (until discharge from the hospital, typically up to 1 week after deliver) will…
- Trial name
- NCT03028259
- Testing
- lab results
- Volunteers
- 161 people
- Sponsor
- St. Louis University
Cardiovascular Disease, Diabetes Type 2
Postprandial Inflammation and Fatty Acids
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on peripheral blood mononuclear cells (PBMC) whole genome expression of obese and type 2…
- Conditions
- Cardiovascular Disease, Diabetes Type 2, Obesity
- Trial name
- PIFA (NCT00977262)
- Testing
- High saturated fat shake, High monounsaturated fat shake, High polyunsaturated fat shake
- Where
- 2 sites in Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Circadian Rhythm, Diabetes
Study of Circadian Clock Properties in Healthy Subjects, Obese and Type 2 Diabetic Patients.
The investigators aimed to characterize human circadian clockwork in healthy individuals in comparison to obese and type 2 diabetic subjects, employing the noninvasive experimental approach allowing the study of circadian profile…
- Conditions
- Circadian Rhythm, Diabetes, Obesity
- Trial name
- NCT02384148
- Testing
- Circadian rhythm measurement, Skin biopsy
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Evaluation of the Effect of Pramlintide on Satiety and Food Intake
This is a single center, randomized, blinded, placebo-controlled, two-period, cross-over study to evaluate the effect of pramlintide on satiety and food intake in normal-weight and obese non-diabetic subjects and in…
- Trial name
- NCT00042601
- Testing
- Pramlintide acetate
- Where
- Australia
- Volunteers
- 51 people
- Sponsor
- AstraZeneca
Pre Diabetic, Obesity & Overweight
The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity
This randomized, crossover interventional study evaluates the effects of real-time (open) versus blinded continuous glucose monitoring (CGM) on glycemic variability, lifestyle behaviors, and metabolic outcomes in adults with…
- Trial name
- CGM (NCT07423065)
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- 3 sites in Slovenia
- Volunteers
- 34 people
- Sponsor
- University of Primorska
Type 2 Diabetes Mellitus (T2DM), Obesity and Type 2 Diabetes
Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
The goal of this clinical trial is to learn if Fenugreek seed powder helps lower body weight and blood sugar in adults with type 2 diabetes who are overweight or obese.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity and Type 2 Diabetes, Hyperglycemia
- Trial name
- NCT07038577
- Testing
- Fenugreek Seed Powder
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- University of Hail