Clinical trials: Obese Individuals
Healthy, Obesity
Metabolic Phenotyping in Humans
Type 2 diabetes (T2D) is a global burden disease affecting almost 200 million people and is expected to nearly double by 2030 (1).
- Conditions
- Healthy, Obesity, Type 2 Diabetes Mellitus
- Trial name
- MetPhe (NCT01298375)
- Where
- Netherlands
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Insulin Resistance
Interleukin-1 Receptor Antagonist and Insulin Sensitivity
Obesity is characterized by continuous low-grade inflammation. This is an important link between obesity and insulin resistance.
- Trial name
- NCT00928876
- Testing
- Anakinra (Kineret)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hypertension, Diabetes
Arts & Health Education to Improve Health, Resilience, and Well-Being
This is an 8-week randomized controlled trial to help address health, resilience, and well-being. Participants are randomized into either a health education group or an arts-based health education group.
- Conditions
- Hypertension, Diabetes, Obesity, COPD
- Trial name
- NCT04154579
- Testing
- HeRe We Arts, HeRe We Ed
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Lisa Gallagher
Obesity
Evaluating the Effectiveness of Financial Incentives in Promoting Weight Loss Among Obese Individuals.
Obesity is a major cause of premature aging and the second leading cause of preventable mortality in the United States, accounting for approximately 110,000 deaths per year.
- Trial name
- NCT00520611
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity and Overweight
Kombucha in Overweight and Obese: Live Vs. Pasteurized Effects on Microbiota, Metabolism, and Liver Function
Kombucha, a fermented beverage made from Camellia sinensis tea (black, oolong, or green) with sugar and a symbiotic culture of bacteria and yeast (SCOBY), has gained global attention for its potential health benefits.
- Trial name
- KOMBIOME (NCT06759324)
- Testing
- Live kombucha (non filtered/ non pasteurized), Pasteurized kombucha (non filtered), Control (sparkling water)
- Where
- 2 sites in Portugal
- Volunteers
- 33 people
- Sponsor
- Associação Centro de Apoio Tecnológico Agro Alimentar
Hypercoagulability, Obesity
Effect of Phototherapy With Exercise on Coagulation in Elderly
It is an interventional study in which 60 obese elderly patients (30 male \& 30 female) estimated to enroll according to random allocation and divided into two groups.
- Trial name
- NCT04503317
- Testing
- active acupuncture low level laser in addition to nasal laser irradiation, treadmill exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Obesity
Fear Conditioning Paradigm in Obesity
Fear processing in obesity and specifically the ability to i) learn and remember threatening stimuli, and ii) implicitly (i.e., unconsciously) and explicitly (consciously) discriminate them from neutral ones, will be investigated…
- Trial name
- GenAllertOB (NCT05768659)
- Testing
- Fear Conditioning
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obesity, Overweight
Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals
This study evaluates the impact of increased intake of fruits and vegetables and whole grains on markers of inflammation and gut microbial composition.
- Trial name
- NCT02602496
- Testing
- Fruits and Vegetables, Whole Grain, Control
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Stress Mental, Dyslipidemia
Effect of macaúba Oil Combined With Green Exercises
Animal model studies involving macaúba oil demonstrate beneficial effects on fat, oxidative stress, and adipogenesis. This study aims to evaluate lipid oxidation and mental stress levels in trained individuals following macaúba…
- Conditions
- Stress Mental, Dyslipidemia, Obesity & Overweight
- Trial name
- NCT07715461
- Testing
- Macauba oil, Daytime Green Exercise, Nighttime Green Exercise
- Where
- 2 sites in Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Obesity
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss.
- Trial name
- TRIUMPH-6 (NCT06859268)
- Testing
- Retatrutide
- Where
- 53 sites in United States, Canada and 1 more
- Volunteers
- 643 people
- Sponsor
- Eli Lilly and Company
Metabolic Syndrome, PreDiabetes
Exercise, Sleep Quality and Nocturnal Fat Oxidation in Metabolic Syndrome
The purpose of the Exerci-Zzz Study is to learn more about how the time of day that exercise is performed influences sleep quality and fat metabolism overnight in adults with metabolic syndrome.
- Conditions
- Metabolic Syndrome, PreDiabetes, Hypertension, Obesity
- Trial name
- ExerciZzz (NCT04105218)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Non-diabetec Obesity, Obesity (Disorder)
Weekly GLP-1 Receptor Agonists in Obese Individuals Without Diabetes
This randomized controlled trial evaluates the efficacy of three weekly GLP-1 receptor agonists (dulaglutide, semaglutide, and tirzepatide) in non-diabetic obese adults.
- Trial name
- NCT07834398
- Testing
- Dulaglutide, Semagludtide, Tirzepatide
- Where
- Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Overweight, Obesity
The Effects of Exercise Snacks on Endothelial Function and Body Composition in Overweight Individuals
This randomized controlled trial investigates the effects of two types of stair-climbing exercise snacks versus moderate-intensity continuous training on vascular health, body composition, and blood lipids in overweight or obese…
- Trial name
- NCT07558421
- Testing
- Short-term stair climbing exercise snack group, Long-duration stair climbing exercise snack group, Moderate-intensity continuous exercise（MICT）
- Volunteers
- 60 people
- Sponsor
- Weifang Medical University
Prediabetes, Brain Insulin Sensitivity
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with…
- Conditions
- Prediabetes, Brain Insulin Sensitivity, Cerebral Blood Flow, Satiety and Food Intake
- Trial name
- NCT07752225
- Testing
- Avocados
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht University Medical Center
Dyslipidemia, Obesity, Abdominal
Effects of Almond Intake on Atherogenic Lipoprotein Particles
Increased abdominal adiposity is a key feature of metabolic syndrome, which describes a cluster of cardiovascular disease (CVD) risk factors that also includes insulin resistance, high blood pressure and an atherogenic…
- Trial name
- NCT01792648
- Testing
- Standard reference diet, Almond supplemented diet, Low carbohydrate reference diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Obesity
The Effects of Exercise on Appetite Regulation in Overweight/Obese Individuals
In this study the Investigators are examining the effects of a 12-week exercise program (intervention) on measures of appetite and food intake regulation in overweight to mildly obese healthy adults.
- Trial name
- NCT02047721
- Testing
- Exercise, Diet
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Adaptive Responses to Overfeeding and Weight
To more effectively address the problem of weight regain following weight loss for obese individuals, this study will evaluate the underlying biology of the reduced obese state.
- Trial name
- ARrOW (NCT03857048)
- Testing
- Weight Loss, Exercise training, Overfeeding
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Periodontitis, Obesity
EVALUATION of GINGIVAL CREVICULAR FLUID and SERUM ASPROSIN LEVELS in OBESE and NORMAL-WEIGHT INDIVIDUALS with PERIODONTITIS
Obesity and periodontitis are chronic inflammatory diseases that share common pathological mechanisms. Asprosin, a novel adipokine discovered in 2016, has not been extensively studied in relation to periodontal tissues.
- Trial name
- NCT06879951
- Testing
- Participants are not assigned an intervention as part of the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Body Image, Executive Function (Cognition)
"Predictive Models of the Morphological Evolution of the Human Body to Improve Adherence and Motivation in Dietetic-nutritional Treatments of Overweight and Obesity" [Modelos Predictivos de Evolución Corporal Para Mejorar la Adherencia en Tratamientos de Sobrepeso y Obesidad]
The objective of this clinical trial is to evaluate the effect of a personalized intervention based on the benefits of 4D body modeling and virtual reality techniques, combined with a dietary-nutritional treatment focused on the…
- Conditions
- Body Image, Executive Function (Cognition), Obesity &Amp;Amp;Amp; Overweight
- Trial name
- Tech4D-Predict (NCT07205029)
- Testing
- Experimental: Nutritional and Virtual reality intervention, Control: Nutritional intervention
- Where
- Spain
- Volunteers
- 133 people
- Sponsor
- Jorge Azorin Lopez
Obesity, Albuminuria
SeMaglutide and Albuminuria Reduction Trial in Obese Individuals Without Diabetes
Study to assess the effects of weekly subcutaneous administration of the GLP1-RA semaglutide 2.4mg on kidney function parameters in obese/overweight individuals at high risk of CKD progression.
- Trial name
- SMART (NCT04889183)
- Testing
- Semaglutide
- Where
- 13 sites in Canada, Germany and 2 more
- Volunteers
- 125 people
- Sponsor
- University Medical Center Groningen