Clinical trials: Obese Non Diabetic
Hyperinsulinemia, Insulin Resistance
EMPOWIR:Enhance the Metabolic Profile of Women With Insulin Resistance
The goal of the study is to identify and treat women with midlife weight gain who have normal blood sugars, but increased insulin levels (hyperinsulinemia) following the performance of a glucose tolerance test.
- Conditions
- Hyperinsulinemia, Insulin Resistance, Obesity
- Trial name
- EMPOWIR (NCT00618072)
- Testing
- metformin and rosiglitazone
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Obesity, Diabetes
Effects of High-Dose Resveratrol in Non-Diabetic Obese Males
The primary aim of our study was to examine the effects of two weeks of oral resveratrol on resting energy expenditure and insulin sensitivity in non-diabetic obese male subjects.
- Trial name
- NCT02247596
- Testing
- Resveratrol
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Khoo Teck Puat Hospital
Diabetes Mellitus, Non-Insulin-Dependent
Effect of Laparoscopic Roux-en-Y Gastric Bypass Surgery on Non-severe Obesity With Type 2 Diabetes Mellitus
The effect of roux-en-Y gastric bypass(RYGB) on patients with type 2 diabetes mellitus(T2DM) and a body mass index(BMI)>35kg/m2 is clear.
- Trial name
- NCT02091323
- Testing
- gastric bypass surgery
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Overweight, Obesity
VDR Gene Polymorphisms and Weight Loss in Non-diabetic Overweight and Obese Subjects
This is a six months intervention study in non-diabetic overweight and obese subjects. Subjects will be counseled for weight loss through diet and exercise.
- Trial name
- NCT03386331
- Testing
- diet and exercise
- Where
- India
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Metabolic Syndrome, Diabetes
Lifestyle Intervention in Obese Arab Women
The study protocol aims to test the hypothesis that a lifestyle intervention program aimed to increase leisure-time physical activity and reduce body weight will improve the parameters of the metabolic syndrome and quality of…
- Trial name
- NCT00273572
- Testing
- Moderate Lifestyle Intervention, Intensive lifestyle intervention
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Obesity, Weight Loss
The Effect of Different Diets on Arterial Stiffness in Obese Patients on Semaglutide
In patients initiating Semaglutide for weight management, the objective is to compare the effect of the Mediterranean diet and the high protein/low carbohydrate (HP/LC) diet CV parameters, namely arterial stiffness, measured by…
- Trial name
- NCT04990024
- Testing
- Dietary Intervention Med Diet, Dietary Intervention HP/LC Diet
- Where
- Lebanon
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Obese Diabetics, Obese Non Diabetic
Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial
titel : Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial Abstract : Background: This study that highlights the different effects of most used three GLP-RA…
- Trial name
- NCT07820111
- Testing
- Dulaglutide 1.5 MG/ML, Semaglutide 2 mg/1.5 ml (1.34 mg/ml), prefilled pen-injector for subcutaneous injection solution, Tirzepatide is administered as part of routine clinical care for obesity management, according to standard prescribing practices. Dosing and treatment duration are determined by the treating physician
- Where
- Saudi Arabia
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Metabolism and Nutrition Disorder, Obesity
A Trial to Assess the Effect of Liraglutide on Gastric Emptying in Healthy Obese Volunteers
This trial is conducted in Europe. The aim of this clinical trial is to investigate the effect of liraglutide on gastric emptying, energy expenditure and appetite, and to evaluate liraglutide pharmacokinetics in non-diabetic…
- Trial name
- NCT00978393
- Testing
- liraglutide
- Where
- Netherlands
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Insulin Resistance, Obesity
Effect of Korean Red Ginseng on Insulin Sensitivity in Non Diabetic Overweight Korean Adults
Korean red ginseng (KRG) is popular worldwide since it is believed to contain ingredients with a variety of health enhancement effects.
- Trial name
- KRGIS (NCT01616134)
- Testing
- Korea red ginseng
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Korean Society of Ginseng
Diabetes
Investigation Into the Effects of Blood Glucose Levels Upon Eating Behavior in Lean and Obese Non-diabetic and Diabetic Subjects
To investigate whether the daily glucose profiles as assessed by continuous glucose monitoring for 1 week of normal weight and obese individuals relate to hunger levels and food intake.
- Trial name
- NCT02673203
- Testing
- Continuous Glucose Monitoring System (CGMS), Food log
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yale University
Type 2 Diabetes, Obesity
Lifestyle Intervention in Obese Non-diabetic Adults With a Family History of Diabetes.
The aim of this study is to investigate weather gradual weight loss achieved with healthy lifestyle changes influence hormonal factors affecting appetite and blood glucose control in obese people without presence of diabetes.
- Trial name
- NCT00993603
- Testing
- 8-month group lifestyle programme
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Royal Bournemouth Hospital
Inflammation
Effect of Pioglitazone on Oxidative Load, Inflammatory End-Points and Vascular Reactivity in Obese Non-Diabetic Patients: A Dose Ranging Study
Pioglitazone decreases oxidative load, inflammatory end points and improves vascular reactivity in obese patients in a dose dependent manner and that this effect is independent of its glucose lowering effects.
- Trial name
- NCT01161394
- Testing
- Pioglitazone 15mg, pioglitazone 30mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Obesity, Dapagliflozin Adverse Reaction
The Effect of Dapagliflozin on Weight Loss in Obese Adults Without Diabetes
The goal of this clinical trial is to examine the effectiveness of a drug named dapagliflozin (tested drug) on weight loss in young adults aged between 18 and 40 years with obesity who are not diagnosed with diabetes.
- Conditions
- Obesity, Dapagliflozin Adverse Reaction, Weight Loss, Effect of Drug
- Trial name
- DAPA-ANDO (NCT06000462)
- Testing
- Dapagliflozin 10mg Tab, Metformin 1000 mg (ttd)
- Where
- Oman
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oman Ministry of Health
Kisspeptin Action on Insulin in Healthy Normal Men, Kisspeptin Action on Insulin in Obese Diabetic Men
KP-10 and Insulin Secretion in Men
Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear.
- Trial name
- NCT03771326
- Testing
- Kisspeptin-10
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Quaid-e-Azam University
Insulin Resistance
Insulin Resistance and Severity of Coronary Artery Disease
this is an observertional study aimed at Study the association between Insulin resistance estimated by HOMA and Angiographic Severity of Coronary Artery Disease in Non Diabetic \& Non Obese Patients.
- Trial name
- NCT05215821
- Where
- Egypt
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Sohag University
Weight Loss, Metabolic Syndrome
Use of Continuous Glucose Monitoring in Non-Diabetic Population to Compliment Signos Mobile Health Platform
Metabolic syndrome and resulting downstream health effects remains a growing health concern. In published trials, the use of continuous glucose monitoring (CGM) assists behavioral changes efforts, leading to improved adherence…
- Conditions
- Weight Loss, Metabolic Syndrome, Pre-diabetes, Central Obesity
- Trial name
- NCT05121844
- Testing
- Continuous Glucose Monitor Device
- Where
- United States
- Volunteers
- 31,187 people, healthy volunteers welcome
- Sponsor
- Signos Inc
Obesity, Metabolic Disease
Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome
Background: Being overweight may cause low-level inflammation. This inflammation may cause some of the medical problems of obesity, like high blood sugar (diabetes) and heart disease.
- Trial name
- NCT02153983
- Testing
- Colchicine 0.6Mg Cap, Colchicine 0.6Mg Tab
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obese Non Diabetic
The Effects of Sodium Phenylbutyrate on Circulating Branched Chain Amino Acids
The aim of this study is to reduce fasting circulating BCAA concentrations in volunteers using Sodium Phenylbutyrate. In addition, we aim investigate the effect of BCAA lowering on fasting blood glucose levels, insulin…
- Trial name
- NCT05028803
- Testing
- sodium phenylbutyrate
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Overweight or Obesity
A Study of BGM1812 Injection in Healthy and Non-diabetic Overweight or Obese Chinese Participants
The purpose of this study is to evaluate the tolerability , safety and pharmacodynamics of BGM1812 administered subcutaneously in healthy and non-diabetic overweight or obese Chinese participants, and to investigate the…
- Trial name
- NCT07294235
- Testing
- BGM1812
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BrightGene Bio-Medical Technology Co., Ltd.
Obesity
Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects
Prospective, randomized, double-blind, controlled-trial 30 subjects in each groups Group - I consume pure D-allulose 5 g 3 times a day before meal to right after meal (with any liquid) and Group - II control group with…
- Trial name
- NCT02988999
- Testing
- D-allulose, erythritol
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University