Clinical trials: Obese Subjects
Subjects With Abdominal Obesity
Grape and Pomegranate Polyphenols in Postprandial Glucose and Related Parameters
The aim of this is study is to evaluate the acute effect of grape and pomegranate polyphenols in the modulation of markers of metabolic syndrome.
- Trial name
- POME-GRAPE-1 (NCT02710461)
- Testing
- Mixture of grape pomace and pomegranate pomace
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Prader-Willi Syndrome
Gut Derived Hormones, Body Composition and Metabolism in Prader-Willi Syndrome
The purpose of this study is to investigate the effects of a GLP-1 agonist on satiety hormones in patients with Prader-Willi Syndrome (genetic defect causing obesity).
- Trial name
- NCT00551343
- Testing
- Exenatide
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Obesity
Expiratory Airflow Limitation in Subjects With Obesity
The purpose of this study is to investigate posture dependent small airway obstruction in subjects with obesity, and to study the capacity of FOT as a measurement tool for small airways obstruction.
- Trial name
- EFL (NCT00865293)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical Center Alkmaar
Weight Maintenance, Overweight
Litramine in Weight Maintenance
The effect of Litramine on weight loss has previously been studied during a 12-week intervention period with promising results. The present study looks into the effect of weight maintenance using Litramine following initial…
- Conditions
- Weight Maintenance, Overweight, Obese
- Trial name
- NCT01505387
- Testing
- Litramine
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- InQpharm Group
Obesity
Effect of VI-0521 (Qsymia®) on Glomerular Filtration Rate (GFR) in Overweight or Obese Healthy Subjects
The main purpose of this study is measure the effect of VI-0521 on kidney function. Specifically, glomerular filtration rate (GFR) will be measured at baseline, after 4 weeks of study treatment, and after an additional 4 weeks of…
- Trial name
- NCT02229214
- Testing
- Qsymia
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Obesity
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Food Effect of NO-13065 in Healthy and Obese Adult Subjects
This clinical trial is the first-in-human study of NO-13065. The purpose of this phase 1 study is to assess the safety and tolerability of single and multiple ascending oral doses and food effect of NO-13065 in healthy and obese…
- Trial name
- NCT04838639
- Testing
- NO-13065
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Factory, Inc.
Healthy
Substrate Metabolism, Growth Hormone Signaling, and Insulin Sensitivity During Fasting
Background: Calorie restriction increases longevity in many species and attenuate the development of chronic disorders including type 2 diabetes, cardiovascular diseases and cancer.
- Trial name
- NCT02500095
- Testing
- Fasting, Saline, Pegvisomant
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Postexercise Hypotension
Continuous vs Aerobic Postexercise Hypotension
This study examines the effect of obesity and gender on postexercise hypotension with three different randomized exercise protocols or varying intensity.
- Trial name
- CAPER (NCT03313375)
- Testing
- Continuous Exercise, Aerobic Interval Exercise
- Where
- 2 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Subjects at Cardiometabolic Risk
Grape Pomace Polyphenols and Cardiometabolic Risk
The aim of this is study is to evaluate the long-term effects of grape polyphenols in the modulation of markers of metabolic syndrome.
- Trial name
- GRAPOM (NCT03076463)
- Testing
- GRAPOM
- Where
- Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Healthy Human Male Subjects
The Influence of Liraglutide on the Reward Properties of Food: an fMRI Study on Healthy Volunteers
Clinical experience has confirmed the anorexic effect of Glucagon-like-peptide 1 (GLP-1) mimetics in comparison to DPP-4 inhibitors.
- Trial name
- NCT01695109
- Testing
- Liraglutide
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy
A Study in Men With Overweight to Test How Well Different Doses of BI 1820237 Are Tolerated When Given as an Injection Alone or in Combination With Liraglutide
The main objective of this trial is to investigate safety, tolerability and pharmacokinetics (PK) and pharmacodynamics (PD) of BI 1820237 alone or together with a single low dose of liraglutide in male subjects with…
- Trial name
- NCT04903509
- Testing
- BI 1820237, Saxenda®, Paracetamol-ratiopharm®
- Where
- Germany
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity
Effect of Diltiazem Administration on CP-945,598 Pharmacokinetics
A recently completed clinical drug interaction study of CP-945,598 with ketoconazole, a potent CYP3A inhibitor, showed that coadministration of CP-945,598 with ketoconazole results in an approximately 5-fold increase in…
- Trial name
- NCT00645463
- Testing
- CP-945,598
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Endocrine System Diseases
Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions
With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.
- Trial name
- NCT02823249
- Testing
- 1.56 g L-Tryptophan, 1.56 g L-Leucine, 50 g Xylitol
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Metabolism and Nutrition Disorder, Obesity
A Two Part Trial Investigating an Anti-obesity Drug in Overweight/Obese Male and Female Healthy Volunteers
This trial is conducted in the United States of America (USA). The aim of this trial is to investigate the safety, tolerability, efficacy and pharmacokinetics (the rate at which the trial drug is eliminated from the body) of NNC…
- Trial name
- NCT01044108
- Testing
- NNC 0070-0002-0453, '2-0453
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Safety and Tolerability
A Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP7570
The trial is a Phase 1, single-centre, randomised and double-blind within cohorts, placebo-controlled, sequential multiple ascending dose trial including three cohorts in Part 1 in a semi-parallel design and one cohort in Part 2…
- Trial name
- NCT06000891
- Testing
- ZP7570
- Where
- Germany
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Zealand Pharma
Obesity
Enteroendocrine Cells Before and After Sleeve Gastrectomy
Morbidly obese patients exhibit impaired secretion of satiation hormones which may contribute to the development of obesity. Bariatric surgery is associated with weight loss and dramatic increase in the secretion of satiation…
- Trial name
- NCT02589587
- Testing
- sleeve gastrectomy, no intervention
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Insulin Resistance
Safety, Pharmacokinetics and Potential Activity of HE3286 in Obese Adult Subjects
The objectives of this study are to evaluate the safety, tolerance and pharmacokinetics of HE3286 when administered daily for 28 days to obese adult subjects and to assess potential activity of HE3286 to decrease insulin…
- Trial name
- NCT00555451
- Testing
- HE3286
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Harbor Therapeutics
Type 2 Diabetes
Exercise, Glucose Kinetics, and the Incretin Effect
Human volunteers will be stratified by oral glucose tolerance status: normal glucose tolerant, impaired glucose tolerant, and type 2 diabetic.
- Trial name
- NCT01607931
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity, Overweight
A Study to Evaluate the Drug Interactions of HRS-7535 With Acetaminophen, Digoxin, Rosuvastatin, and Omeprazole in Obese or Overweight Subjects
This study is an open-label, fixed-sequence, self-controlled Phase I clinical trial conducted among obese or overweight subjects, with a planned enrollment of 40 adult subjects.
- Trial name
- NCT07269756
- Testing
- HRS-7535 Tablets, Paracetamol Tablets, Digoxin Tablets
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Inflammation
To Study the Effect of Vytorin on Intracellular Lipid and Inflammation in Obese Subjects
This study focuses on the use of Vytorin to study inflammatory markers in subjects with normal cholesterol.
- Trial name
- NCT01420328
- Testing
- Vytorin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University at Buffalo