Clinical trials: Obese Subjects
Vascular Disease, Peripheral, Physical Inactivity
Inter-individual Physiological Response to a Training and Detraining Period in Cardiometabolic Risk Factors Subjects
Background: Although exercise training is a well described therapy for some cardiometabolic diseases such as obesity, type 2 diabetes, arterial hypertension, and metabolic syndrome, there is scarcity of knowledge about the…
- Conditions
- Vascular Disease, Peripheral, Physical Inactivity, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- VASCU-HEALTH (NCT05710653)
- Testing
- Exercise training intervention
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cristian Alvarez
Obese With Comorbidities, Overweight With Comorbidities
Study for Multiple Doses of HM15136(Efpegerglucagon) in Obese or Overweight Subjects With Comorbidities
The planned period of each cohort is 22 weeks including subject screening, treatments for 12 weeks, and follow up period.
- Conditions
- Obese With Comorbidities, Overweight With Comorbidities, Type2 Diabetes
- Trial name
- NCT04167553
- Testing
- HM15136
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Overweight (BMI > 25), Obesity & Overweight
Gummy Candies With Maqui Berry
The goal of this clinical trial is to learn if Maqui berry gummy encapsulated (GMM) compared to non-encapsulated (GM) can improve glycemic response in overweight adults.
- Conditions
- Overweight (BMI > 25), Obesity & Overweight, Insulin Resistance Syndrome, Type 2 Diabetes
- Trial name
- MaquiGUM (NCT07373795)
- Testing
- GM, Control, GMM
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Gonzalo Jorquera, PhD
Hypertension, Concurrent Obesity
Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive Subjects
This study investigated the effects of LCZ696 on insulin sensitivity, lipolysis, and oxidative metabolism in obese hypertensive subjects.
- Trial name
- NCT01631864
- Testing
- LCZ696, amlodipine
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
Efficacy of D-allulose on Weight and Fat Loss and Insulin Resistance in Non-diabetic Obese Subjects
Prospective, randomized, double-blind, controlled-trial 30 subjects in each groups Group - I consume pure D-allulose 5 g 3 times a day before meal to right after meal (with any liquid) and Group - II control group with…
- Trial name
- NCT02988999
- Testing
- D-allulose, erythritol
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Healthy, Overweight and Obesity
Fiber-enriched Croissant Consumption and Effects on Metabolic Status, Appetite and Gut Microbiota
The aim of this study is to evaluate the effect of a daily consumption for 2 weeks of a sourdough croissant enriched with dietary fibers vs a control sourdough croissant with no fiber added on daily energy intakes, fasting…
- Trial name
- CROMA (NCT04999280)
- Testing
- Fiber Croissant (FIBCRO) Group, Control Croissant (CONCRO) Group
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Federico II University
Type 2 Diabetes Mellitus
A Study to Evaluate the Safety and Tolerability of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus
This is a Phase 2a, randomized, blinded, placebo-controlled study in up to 20 overweight or obese participants with type 2 diabetes mellitus.
- Trial name
- NCT03745937
- Testing
- MEDI0382
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- MedImmune LLC
Obesity
Shifting and Distribution of Foot Pressure Among Obese Subjects
Background: The foot is considered a sensitive structure of musculoskeletal system that bears significant loads of the body weight during walking.
- Trial name
- NCT03441763
- Testing
- Emed foot device
- Where
- Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Obesity, Insulin Resistance
Effect of Dietary Protein and Energy Restriction in the Improvement of Insulin Resistance in Subjects With Obesity
The prevention of obesity and its main medical complications, such as hypertension, type 2 diabetes and cardiovascular diseases, have been become a health priority.
- Trial name
- NCT03627104
- Testing
- Normoprotein diet with animal protein, Normoprotein diet with vegetable protein, High-protein diet with animal protein
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Type II Diabetes Mellitus
Efficacy and Safety of GL0034 in Overweight or Obese Adults With Type II Diabetes Mellitus
This is a phase II, randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of GL0034 among type II diabetes mellitus subjects who are obese or overweight with weight-related comorbidities.
- Trial name
- NCT07282743
- Testing
- GL0034 Dose Level 1, GL0034 Dose Level 2, GL0034 Dose Level 3
- Where
- 21 sites in United States, India
- Volunteers
- 285 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Adipose Tissue, Brown, Brown Adipose Tissue
Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).
This study investigates repetitive cold-water exposure on brown fat activity assessed by PET/CT scanning. Furthermore we will assess glucose control upon winter-swimming.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Uncoupling Protein 1, Cold Exposure
- Trial name
- WinterBAT (NCT03541096)
- Testing
- Winter Swimming, Control group
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Kristian Karstoft
Resting Metabolic Rate, Overweight Subjects
A Study to Investigate the Effect of 7-Keto on Resting Metabolic Rate in Overweight Adults
This study will investigate the effect of two different doses of 7-Keto compared to placebo on resting metabolic rate. One third of subjects will be given the lower 7-Keto dose, one third will be given the higher 7-Keto dose and…
- Trial name
- 15KMHI (NCT04782024)
- Testing
- 7-Keto 50mg, 7-Keto 25mg
- Where
- 2 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Obesity
To Determine Tolerability to Glucagon Infusion in Obese Subjects
To further understand the tolerability of glucagon.
- Trial name
- GIO (NCT02817659)
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity
Effects of Plasmalogen on Obese Subjects
This is a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of scallop-derived plasmalogen on brain fatigue, body weight and changes in blood plasmalogen in obese subjects aged 20-75 years old.
- Trial name
- NCT03295188
- Testing
- Plasmalogen
- Where
- Japan
- Volunteers
- 83 people
- Sponsor
- Japanese Plasmalogen Society
Obesity
A First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM15211(Efocipegtrutide)
Single ascending dose of HM15211 in healthy obese subjects.
- Trial name
- NCT03374241
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Diet, Healthy, Obesity
Olfactory and Taste Changes During Fasting Mimicking Diet (FMD)
Literature experiences demonstrated the impact of medically-assisted pulsed fasting on olfactory behavior in both the animal and human models and - conversely - the lack of homogeneous results linked - up to now - to…
- Conditions
- Diet, Healthy, Obesity, Olfaction Disorders
- Trial name
- FMD1 (NCT04529161)
- Testing
- Fasting Mimicking Diet (FMD), Routinary diet habits
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Uniter Onlus
Prader-Willi Syndrome
Phase 2 Trial to Evaluate Safety and Efficacy of Setmelanotide (RM-493) in Obese Participants With Prader-Willi Syndrome
The purpose of this study was to evaluate the effects of a once daily subcutaneous injectable formulation of setmelanotide in obese participants with Prader-Willi syndrome on tolerability, weight loss, and hyperphagia-related…
- Trial name
- NCT02311673
- Testing
- Setmelanotide
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Drug Safety
Pharmacokinetics of Ceftaroline in Normal and Obese Subjects
The purpose of this study is to characterize plasma and urinary concentrations of ceftaroline following intravenous administration of a single dose of ceftaroline 600 mg in healthy subjects who are normal weight, overweight, and…
- Trial name
- NCT01648127
- Testing
- Ceftaroline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Keith A. Rodvold
Obesity, Nutritional and Metabolic Diseases
A Study of the Safety and Effectiveness of JNJ-16269110 (R256918) in Overweight and Obese Patients
This study investigates the effectiveness and safety of 12 weeks of treatment with JNJ-16269110 (R256918), in overweight and obese patients.
- Conditions
- Obesity, Nutritional and Metabolic Diseases, Metabolic Diseases, Nutrition Disorders
- Trial name
- NCT00622765
- Testing
- R256918
- Where
- 18 sites in Belgium, Denmark and 5 more
- Volunteers
- 321 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Overweight, Obesity
A Research Study to Look at How Semaglutide Affects Gastric Emptying in People With Obesity
This study will look at how the emptying of the participant's stomach after a meal is affected by semaglutide (a new medicine) compared to a "dummy" medicine.
- Trial name
- NCT03842202
- Testing
- Semaglutide
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Novo Nordisk A/S