Clinical trials: Obese Subjects
Type 2 Diabetes Mellitus
A Study of TG103 Injection in Overweight/Obese Subjects With Type 2 Diabetes
The main purpose of this study is to evaluate the efficacy, safety, PK and PD characteristics of different doses of TG103 injection in overweight/obese subjects with type 2 diabetes mellitus.
- Trial name
- NCT05063253
- Testing
- TG103
- Volunteers
- 208 people
- Sponsor
- CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.
Dysglycemia, Obesity
Effects of Cinnamon Supplementation on Glucose Metabolism in Patients With Pre-diabetes
The transition from normal glucose tolerance to overt type 2 diabetes mellitus (T2D) encompasses a variety of glycemic abnormalities that are commonly referred to as 'prediabetes'.
- Trial name
- Cinnamon (NCT03219411)
- Testing
- Cinnamon
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joslin Diabetes Center
Overweight and Obesity, Type2 Diabetes
A Phase 1 Study of DD01 in Overweight/Obese Subjects With T2DM and NAFLD
This is a Phase 1, first in human (FiH), randomized, double-blind, placebo-controlled, single ascending dose (SAD) and multiple ascending dose (MAD) study to investigate the safety, tolerability, PK and PD of DD01 administered by…
- Conditions
- Overweight and Obesity, Type2 Diabetes, NAFLD
- Trial name
- NCT04812262
- Testing
- DD01
- Where
- 4 sites in United States, Puerto Rico
- Volunteers
- 255 people
- Sponsor
- Neuraly, Inc.
Obesity, Diabetes
Acute Effects of Dietary Fiber on Postprandial Responses in Lean and Overweight Subjects
It has been suggested that obesity occurs because the colonic microbes in obese individuals, compared to those who are lean, produce more short chain fatty acids during the fermentation of dietary fiber; this means that obese…
- Trial name
- NCT02795559
- Testing
- Glucose, Inulin, Resistant starch
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Volunteer
A Multiple Dose Study Of Ertugliflozin (PF-04971729, MK-8835) In Otherwise Healthy Overweight And Obese Volunteers (MK-8835-037)
Ertugliflozin (PF-04971729, MK-8835) is under development for the treatment of Type 2 Diabetes. The primary purpose of this trial is to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, of multiple oral…
- Trial name
- NCT01018823
- Testing
- Ertugliflozin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Behcet Disease, Obesity
Diet Restiction in Subjects With Behcet Disease and Complaint of Tinnitus
otogic problems are varied in bechet disorder, tinnnitus is one of these problems. obesity may increase this probelm
- Conditions
- Behcet Disease, Obesity, Subjective Tinnitus
- Trial name
- NCT07702149
- Testing
- diet restriction
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Obesity and Overweight
Phase Ia Clinical Study of HDM1005 Injection
This is a randomized, double-blind, placebo-controlled, single-dose, dose-escalation Phase Ia clinical study. It is aimed to evaluate the safety, tolerability, PK and PD characteristics of HDM1005 injection in healthy adult…
- Trial name
- NCT06640647
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Healthy Volunteer
A Study of ABBV-295 Subcutaneous Injections to Assess Pharmacokinetics and Adverse Events in Healthy Adult Women Participants With Overweight or Obesity Taking Oral Contraceptives
This Study of ABBV-295 subcutaneous injections will assess pharmacokinetics and adverse events in healthy adult women participants with overweight or obesity taking oral contraceptives.
- Trial name
- NCT07414784
- Testing
- ABBV-295, Levonorgestrel/Ethinyl Estradiol
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- AbbVie
Obstructive Sleep Apnea, Diabetes Mellitus
The Effect of Lifestyle Intervention Versus Gastric Bypass on Various Comorbidities in Morbidly Obese Subjects
This follow up study (>1 year) aims to compare the effects of lifestyle intervention and gastric by pass surgery on various comorbidities associated with morbid obesity.
- Conditions
- Obstructive Sleep Apnea, Diabetes Mellitus, Hypertension
- Trial name
- NCT00273104
- Testing
- Bariatric surgery, Intensive lifestyle intervention
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- The Hospital of Vestfold
Body-Weight Trajectory
Impact of Health Lifestyle on Body Weight
Pharmacotherapy becomes an important and effective approach to improve body weight. However, it still remains unclear how to manage potential fluctuation after its cessation.
- Trial name
- NCT05608226
- Testing
- Lifestyle Education Program
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Shanghai Zhongshan Hospital
Obesity
Study for Short Term Weight Loss in Candidates for Bariatric Surgery
The purpose of this study is to determine whether the GI Endobarrier Liner is safe and effective.
- Trial name
- NCT00985491
- Testing
- Endobarrier Liner
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Morphic Medical Inc.
Overweight/Obesity
Clinical Study of IBI362 in Healthy Chinese Male Subjects
This is a study to evaluate the pharmacokinetic characteristics and safety of IBI362 lyophilized powder and IBI362 liquid formulation in healthy Chinese male subjects.
- Trial name
- NCT04773977
- Testing
- IBI362 liquid formulation, IBI362 lyophilized powder
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Obesity, Insulin Resistance
The Primary Objective of This Study is to Determine Whether MICARDIS® Improves Insulin Sensitivity in Overweight or Obese, Non-diabetic, Normotensive Subjects
The primary objective of this study is to determine whether MICARDIS® improves insulin sensitivity in overweight or obese, non-diabetic, normotensive subjects.
- Trial name
- NCT00146289
- Testing
- MICARDIS® (telmisartan)
- Where
- 17 sites in United States, Canada and 3 more
- Volunteers
- 138 people
- Sponsor
- Boehringer Ingelheim
Obese Subjects With Polycystic Ovary Syndrome (PCOS)
A Multicenter, Randomized, Double-blind, Placebo-parallel-controlled Phase II Clinical Study Evaluating the Efficacy and Safety of HRS9531 Injection in Obese Subjects With Polycystic Ovary Syndrome
Randomized, double-blind, placebo-controlled study of HRS9531 in PCOS subjects
- Trial name
- NCT06595797
- Testing
- HRS9531
- Volunteers
- 144 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Overweight, Glucose Intolerance
Diabetes Prevention In Estrie
This study compared the efficacy at one year of an interdisciplinary approach including individual counseling and group seminars versus group seminars alone to induce weight loss in subjects at high risk of developing type 2…
- Trial name
- NCT00991549
- Testing
- interdisciplinary intervention or meeting-seminars
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Université de Sherbrooke
Obesity
Grape Polyphenols and Second-meal Effect
The aim of this is study is to evaluate the effects of a single intake of grapes (a polyphenol-rich food) in postprandial metabolism in subjects with obesity, including a first intake (high-fat breakfast) after overnight fasting…
- Trial name
- GRAPESECOND (NCT03741218)
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Diabetes Mellitus, Type 2, Overweight and Obesity
Effect of a Low-calorie and High-protein Diet Specially Rich in Animal Protein Compared to a Low-calorie and High-protein Diet Specially Rich in Plant Protein on Glucose Metabolism in Subjects With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
The aim of the study is to explore the effect of a low-calorie diet rich in protein (with a content of 35% of the total calories of the diet), mostly coming from animal sources (75% of total protein), compared to a hypocaloric…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, PreDiabetes
- Trial name
- NCT05456347
- Testing
- Low-calorie and high-protein diet with the majority of protein coming from animal sources., Low-calorie and high-protein diet with the majority of protein coming from plant sources.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Obesity
A Research Study to Investigate How Well NNC0165-1875 in Combination With Semaglutide Works in People With Obesity
The study is looking at a new medicine to help people lose weight. In this study participants will either get semaglutide and NNC0165-1875 or semaglutide and a "dummy" medicine (placebo).
- Trial name
- NCT04969939
- Testing
- Semaglutide 2.4 mg and NNC0165-1875 2.0 mg, Semaglutide 2.4 mg and NNC0165-1875 1.0 mg
- Where
- 25 sites in United States
- Volunteers
- 120 people
- Sponsor
- Novo Nordisk A/S
Overweight, Obesity
A Research Study to Look at How Semaglutide Affects Gastric Emptying in People With Obesity
This study will look at how the emptying of the participant's stomach after a meal is affected by semaglutide (a new medicine) compared to a "dummy" medicine.
- Trial name
- NCT03842202
- Testing
- Semaglutide
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Novo Nordisk A/S
Overweight, Obesity
Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity
This study will look at participants' body weight from the start to the end of the study. The study will last for about 1½ years.
- Trial name
- STEP 8 (NCT04074161)
- Testing
- Semaglutide, Liraglutide
- Where
- 19 sites in United States
- Volunteers
- 338 people
- Sponsor
- Novo Nordisk A/S