Clinical trials: Obesity, Morbid
Morbid Obesity
Surgical Conditions During Laparoscopic Bariatric Surgery
Obesity affects more than 78 million adults in the United States and it is estimated that 35% of the US population is obese. Currently, more than 179,000 bariatric procedures are performed in the US each year with the majority of…
- Trial name
- NCT02703909
- Testing
- Rocuronium, Insufflation pressure
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Missouri-Columbia
Obesity, Morbid, Metabolic Syndrome
Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Variable outcomes after weight loss surgery are likely attributable to complex, poorly understood mechanisms. Due to the significant impact that morbid obesity has on a patient's health, successful management of obesity and its…
- Conditions
- Obesity, Morbid, Metabolic Syndrome, NASH - Nonalcoholic Steatohepatitis
- Trial name
- NCT04841057
- Testing
- 50 cm BP limb length, 100 cm BP limb length, 150 cm BP limb length
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Metabolic Syndrome
Effects of Leptin Replacement in Children
To assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous family. The hypothesis is that leptin replacement will have significant effects on endocrine function.
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00659828
- Testing
- Recombinant methionyl human leptin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Obese Patients With Bariatric Surgery
Physical Condition and Bariatric Surgery
The aim of this project is to investigate in obese patients the changes induced by bariatric surgery on the various components of the physical condition and their postoperative evolution following an intervention combining a…
- Trial name
- CaPaCITy (NCT03197857)
- Testing
- Physical activity program : aquabike, Physical activity program : bicycle, Physical activity program : with protein supplementation
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
Morbid Obesity
Bariatric Surgery and HDL-cholesterol
Objective: to assess the effect of gastric bypass on HDL-cholesterol concentration and its Apolipoprotein A4 content at 1 year following bariatric surgery in comparison with a hypocaloric diet.
- Trial name
- NCT01707771
- Testing
- Roux-en-Y gastric bypass, diet and lifestyle modifications
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Obesity, Morbid, Insulin Resistance
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, Insulin Resistance and Central Reward System
Background: Morbid obesity is associated with decreased brain µ-opioid receptor availability, possibly resulting in higher food intake needed to gain pleasure from eating.
- Trial name
- BariBrainPET (NCT05080205)
- Testing
- Bariatric surgery
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Morbid Obesity
Laparoscopic Gastric Plication Compared With Laparoscopic Sleeve Gastrectomy
The study must be performed in 100 patients suffering from morbid obesity, the procedure will be performed under general anesthesia doing two or three layers of suture to achieves gastric imbrication until transform the stomach…
- Trial name
- LGP (NCT01293877)
- Testing
- Laparoscopy surgery for morbid obesity
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bikkur Holim Hospital
Obesity
Intravenous Ibuprofen for Laparoscopic Bariatric Surgery
Primary objective of this study is to test hypothesis that IV ibuprofen decreases 24 hours morphine requirement using IV PCA in patients after laparoscopic bariatric surgery.
- Trial name
- NCT01707251
- Testing
- Intravenous Ibuprofen, Saline
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Jacobi Medical Center
Morbid Obesity
Two or Five cm From Pylorus During Laparoscopic Sleeve Gastrectomy
The investigators compare two techniques for laparoscopic sleeve gastrectomy. in the first one the distal margin of stapling is 2 cm from the pylorus and in the second it is 6 cm away from the pylorus.
- Trial name
- NCT01846637
- Testing
- laparoscopic sleeve gastrectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Meal, Obesity, Morbid
Microstructural Analysis of Ingestive Behavior After Roux-en-Y Gastric Bypass - Pilot
The ability to assess ingestion in fine detail over the time course of a liquid meal allows for comparison of early and late meal features of drinking and may help dissociate manipulations (surgical, neural, pharmacological…
- Conditions
- Meal, Obesity, Morbid, Food Deprivation, Bariatric Surgery
- Trial name
- NCT03747445
- Testing
- Roux-en-Y gastric bypass
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marco Bueter
Obesity, Morbid
4XL Study - Obesity Surgery in Adolescence
The purpose of this study on adolescents between 13 and 18 years of age with morbid obesity is to determine whether surgical treatment gives more health benefits than standard conservative treatment, and if laparoscopic gastric…
- Trial name
- 4XL (NCT00923819)
- Testing
- Laparoscopic gastric bypass, Standard conservative treatment
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Sykehuset i Vestfold HF
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Lercanidipine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03497156
- Testing
- Lercanidipine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity, Bariatric Surgery
Randomized Trial of Preoperative Diets Before Bariatric Surgery
Randomized clinical trial of two preoperative diets before bariatric surgery (gastric bypass)comparing standard diet and Prodimed (VLCD) in 100 morbidly obese patients selected for a gastric bypass procedure
- Conditions
- Morbid Obesity, Bariatric Surgery, Gastric Bypass
- Trial name
- NCT01652105
- Testing
- Standard diet versus standard VLCD (Prodimed)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Lievensberg Ziekenhuis
Obesity, Morbid
Swedish Adjustable Gastric Banding Observational Cohort Study
Longitudinal prospective cohort study of patients treated consecutively by SAGB in a sample of centers representative of this activity in France.
- Trial name
- NCT01183975
- Where
- France
- Volunteers
- 517 people
- Sponsor
- Ethicon Endo-Surgery (Europe) GmbH
Adipose Tissue Inflammation, Morbid Obesity
n-3 Polyunsaturated Fatty Acids in Obesity
Inflammation in the adipose (fat) tissue is an important condition leading to metabolic derangements and cardiovascular disease in obese patients.
- Trial name
- PUFA-ATI (NCT00760760)
- Testing
- reesterified long-chain n-3 polyunsaturated fatty acids (EPA, DHA), control
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Medical University of Vienna
Obesity, Morbid, NASH
The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis
Background: Ketosis after bariatric surgery is a metabolic process that occurs when the body breaks down fat for energy because of not getting enough carbohydrates.
- Conditions
- Obesity, Morbid, NASH, Ketosis, Keto Acidosis
- Trial name
- NCT06338969
- Testing
- Carbohydrate Restriction after a Gastric Bypass
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Morbid Obesity, Hiatal Hernia
Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients
Background: Obesity and hiatal hernia are both risk factors of gastroesophageal reflux disease (GERD), and the incidence of hiatal hernia is much higher in morbidly obese patients.
- Conditions
- Morbid Obesity, Hiatal Hernia, Gastroesophageal Reflux Disease, Sleeve Gastrectomy
- Trial name
- NCT03776669
- Testing
- Laparoscopic sleeve gastrectomy + Hiatal hernia repair, Laparoscopic sleeve gastrectomy alone
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Irbesartan
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03476603
- Testing
- Irbesartan
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Morbid Obesity
Gastric Recalibration After Endoscopic Sleeve Gastroplasty
Endoscopic sleeve gastroplasty (ESG) is a technique used for bariatric surgery, with results comparable to conventional surgery, in order to treat morbid obesity.
- Trial name
- ESG-IRM (NCT04945473)
- Testing
- Endoscopic placement of additional sutures
- Where
- France
- Volunteers
- 100 people
- Sponsor
- IHU Strasbourg
Morbid Obesity
Changes in Ingestive Behaviour Following Gastric Bypass
The gastric bypass procedure is known to be one of the most successful treatments for morbid obesity and Type 2 diabetes mellitus, and has been shown to decrease appetite, energy intake, body weight and glycemia both in the short…
- Trial name
- NCT03113305
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Ulster