Clinical trials: Obesity, Overweight
Obesity, Metabolic Syndrome
Effects of Leptin Replacement in Children
To assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous family. The hypothesis is that leptin replacement will have significant effects on endocrine function.
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00659828
- Testing
- Recombinant methionyl human leptin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Obesity, Diabetes
Microbes and Bariatric Surgery
The investigators will study people who are obese and will be treated by bariatric surgery. The investigators will test the hypothesis that some of the features of obesity are related to the bacteria in the gastro-intestinal…
- Conditions
- Obesity, Diabetes, Periodontal Disease
- Trial name
- NCT01130207
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- State University of New York - Upstate Medical University
Diabetes Mellitus, Type 1, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and Overweight or Obesity
The main purpose of this study is to learn more how tirzepatide affects stomach emptying in participants with Type 1 Diabetes Mellitus (T1DM) and overweight or obesity.
- Conditions
- Diabetes Mellitus, Type 1, Overweight, Obesity
- Trial name
- NCT07803744
- Testing
- Tirzepatide, Acetaminophen
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eli Lilly and Company
Obesity, Insulin Resistance
Protection Against Insulin Resistance in Obesity
The overall goal of this project is to identify factors that "protect" some obese adults from becoming insulin resistant. Identifying mechanisms that help protect some obese adults from developing insulin resistance could lead to…
- Trial name
- PAIR (NCT02717832)
- Testing
- hyperinsulinemic-euglycemic clamp
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Nonalcoholic Steatohepatitis (NASH)
A Clinical Study to Evaluate the Efficacy and Safety of Aramchol in Subjects With NASH (ARMOR)
An Open-Label Part was added: This part will enroll in selected sites which are less affected by the COVID-19 pandemic. 150 subjects with NASH and fibrosis confirmed by liver histology (F1-F3) will be randomized into 3 groups…
- Trial name
- ARMOR (NCT04104321)
- Testing
- Aramchol free acid
- Where
- 2 sites in United States
- Volunteers
- 157 people
- Sponsor
- Galmed Research and Development, Ltd.
Obesity, Sarcopenic Obesity
Sarcopenic Obesity as a Risk of Premature Aging
Recently, numerous signaling proteins derived from adipose tissue and/or skeletal muscle have been described and are involved in the pathogenesis of obesity and the pathophysiology of aging.
- Conditions
- Obesity, Sarcopenic Obesity, Aging
- Trial name
- SARCOBEAGING (NCT05443711)
- Testing
- No intervention, observational study
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospital de Leon
Abdominal Obesity
Multi-component Workplace Energy Balance Intervention
The purpose of the WorkACTIVE-P study is to assess the outcome of an innovative multi-component intervention focused on increasing energy expenditure and re-balancing the disrupted energy balance equation of sedentary workplaces…
- Trial name
- WorkACTIVE-P (NCT02561611)
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pennington Biomedical Research Center
Child Obesity
Community Active and Healthy Families Pragmatic Trial
This is a randomized pragmatic trial of the Community-AHF intervention to evaluate its effectiveness at decreasing body mass index in 5-12 year old children.
- Trial name
- NCT07868471
- Testing
- Community Active and Healthy Families Intensive Health Behavior and Lifestyle Treatment
- Volunteers
- 416 people
- Sponsor
- University of Colorado, Denver
Obesity, Physical Activity
A Sustainable Diet for Hadassah Employees Workers
The aim of this protocol is to use a multidisciplinary approach to convey nutrition and activity messages to randomly selected Hadassah Medical Center employees.
- Trial name
- NCT01686399
- Testing
- Nutritional and Activity Promotion
- Where
- Israel
- Volunteers
- 450 people
- Sponsor
- Hadassah Medical Organization
Obesity
Leak Pressure After Reinforcement in Gastric Specimens
The investigators hypothesize that staple line reinforcement will result in a higher leak pressure than a non-reinforced staple line closure in the resected gastric specimens from laparoscopic sleeve gastrectomy.
- Trial name
- NCT02272907
- Testing
- Injection of saline solution into specimen to test bursting pressure.
- Sponsor
- Santa Barbara Cottage Hospital
Obesity, Overweight
A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes.
- Conditions
- Obesity, Overweight, Type 2 Diabetes
- Trial name
- NCT06993792
- Testing
- Orforglipron
- Where
- 80 sites in United States, Argentina and 5 more
- Volunteers
- 1,400 people
- Sponsor
- Eli Lilly and Company
Obesity Hypoventilation Syndrome (OHS)
Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome
It remains unclear whether CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration, despite optimization of upper airway obstructive events, if maximum CPAP pressure is reached.
- Trial name
- AVAPS (NCT06442163)
- Testing
- AVAPS study was performed within 1 week of the CPAP titration attempt failure, using the auto-titrating EPAP (AE), the OmniLab Advanced +, System One device (Philips Respironics, Murrysville, PA, U.S.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Obesity, Obesity, Morbid
Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss
The Investigators propose suture plication placement at the distal gastric body drives a significant portion of weight loss in endoscopic sleeve and sutures only need to be placed in the distal gastric body.
- Conditions
- Obesity, Obesity, Morbid, Metabolic Disease, Weight, Body
- Trial name
- NCT06299644
- Testing
- Endoscopic Sleeve Gastroplasty - Belt and Suspenders, Endoscopic Sleeve Gastroplasty - Belt
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Obesity
Mechanisms of Semaglutide Therapy in Heart Failure Patients
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, primarily used for treatment of type-2 diabetes mellitus. GLP-1 receptors are present on pancreatic islet β-cells, δ-cells and α-cells.
- Trial name
- SEMAHEART (NCT06541509)
- Testing
- Semaglutide
- Where
- 3 sites in United States, Slovenia
- Volunteers
- 10 people
- Sponsor
- University Medical Centre Ljubljana
Glucose Intolerance, Obesity
The Snack Study: The Feasibility of Changing Night-time Food Choices to Improve Glucose Tolerance in Pregnancy
Obesity during pregnancy increases the risk for high glucose and diabetes in the mother, and for obesity and comorbid metabolic disease in the offspring.
- Trial name
- NCT02634593
- Testing
- Low glycemic load snacks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Morbid Obesity
Liposomal Amphotericin B (AmBisome) Pharmacokinetics Given as a Single Intravenous Dose to Obese Patients (ASPEN)
Dosing guidelines for liposomal amphotericin B (AmBisome) in (morbidly) obese patients are not available. Subsequently, the pharmacokinetic profile of AmBisome in this specific patient population is still largely unknown.
- Trial name
- NCT02320604
- Testing
- Administration of study drug
- Where
- 2 sites in Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Visceral Obesity, Non-Alcoholic Fatty Liver Disease
Effect of a Multi-ingredient on Visceral Adiposity and Non-alcoholic Fatty Liver Disease in Individuals With Abdominal Obesity
The aim of this study is to validate the efficacy of specific combination of different natural histidine-related amino acids in the reduction of visceral fat and liver steatosis, as well their associated comorbidities, in…
- Trial name
- FATHIS (NCT05807204)
- Testing
- Multi-ingredient of L-histidine, L-serine, L-carnosine and N-Acetylcysteine
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Obesity, Diabetes
The Acute Effect of Malt Extract Versus Sucrose on the Response of Glucose and Insulin, Subjective Appetite Sensations and ad Libitum Energy Intake
Sucrose is the most used sweetener in beverage and foods in Denmark. Other sweeteners with other composition and amount of carbohydrates could be of interest in order to decrease the glucose and insulin responses after intake of…
- Trial name
- Harboe (NCT01615081)
- Testing
- The acute effect of malt extract versus sucrose on the response of glucose and insulin, subjective appetite sensations and ad libitum energy intake
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Overweight and Obesity
Prevention and Intervention of Overweight and Obesity in Preschool Children
Obesity is an important public health problem, which is directly related to the risk of childhood complications and the increase of incidence rate and mortality of adult complications.
- Trial name
- NCT06562465
- Testing
- dietary and exercise management, no dietary and exercise management
- Where
- 2 sites in China
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Chen Li
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