Clinical trials: Obesity, Overweight
Diabetes type2, Obesity
The RESET System Pivotal Clinical Trial (Protocol Revision K)
A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the RESET System for Glycemic Improvement in Patients with Inadequately Controlled Type 2 Diabetes and Obesity, the STEP-1 Study.
- Trial name
- STEP-1 (NCT04101669)
- Testing
- RESET Liner
- Where
- 27 sites in United States
- Volunteers
- 264 people
- Sponsor
- Morphic Medical Inc.
Obesity, Mentally Ill Persons
Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness
The proposed project aims to pilot and adapt a scalable and sustainable interactive obesity treatment approach (iOTA) program for adults with serious mental illness (SMI).
- Trial name
- iOTA-SMI (NCT03695289)
- Testing
- iOTA SMI, Health Education Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Obesity, Childhood
Together We STRIDE (Strategizing Together Relevant Interventions for Diet and Exercise)
Obesity among Hispanic children in the Lower Yakima Valley of Washington State is alarmingly high. This study proposes to implement a comprehensive, multi-level intervention among children, families, the schools, and the…
- Trial name
- NCT02982759
- Testing
- Multi-Level Intervention, Genetic Newsletters
- Where
- United States
- Volunteers
- 888 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2)
Real-World Two-Year Weight Loss Outcomes With Breath Biofeedback
The goal of this retrospective observational study is to evaluate the real-world durability of weight loss among adults with overweight or obesity who used the Key to Health breath-biofeedback mHealth program.
- Conditions
- Overweight (BMI > 25), Obesity (Body Mass Index >30 kg/m2), Obesity & Overweight
- Trial name
- NCT07430618
- Testing
- Breath acetone biofeedback device with mHealth program
- Where
- Canada
- Volunteers
- 11,524 people
- Sponsor
- University of British Columbia
Glucose Intolerance, Insulin Resistance
Iron and Insulin Resistance in Overweight and Obese Humans
Determine the effects of reducing whole-body iron stores in overweight/obese subjects (via one-time blood donation) on adipose tissue iron content, factors regulating iron homeostasis and lipolytic rate in adipose tissue, as well…
- Conditions
- Glucose Intolerance, Insulin Resistance, Iron Metabolism
- Trial name
- Fe (NCT03348020)
- Testing
- Blood Donation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Respiratory Failure
Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients
This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with…
- Trial name
- TAILOR-PEEP (NCT07359261)
- Testing
- Esophageal pressure-guided PEEP titration, Standard care PEEP management
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta
Obesity
A Family-Based Weight Loss Intervention for Youth With Intellectual Disability
The purpose of this randomized controlled trial is twofold. First, to examine the efficacy of a 24-session, 6-month family-based behavioral intervention (FBBI) - as compared to a waitlist FBBI group, which later receives the same…
- Trial name
- HealthU (NCT02033642)
- Testing
- Family Based Behavioral Intervention, Maintenance
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Triclosan Effects on Microbial Flora
Triclosan, Triclocarban, and the Microbiota
Triclosan (5-chloro-2 (22,4-dichlorophenoxy)phenol) is a broad-spectrum antibacterial and antifungal agent that is found in thousands of common household products, including deodorants, toothpaste, "antibacterial" soaps, cleaning…
- Trial name
- NCT01509976
- Testing
- triclosan/triclocarban-containing personal care products
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Insulin Resistance
Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Effects of Exercise Training
Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge.
- Conditions
- Obesity, Insulin Resistance, Type2 Diabetes, Exercise Training
- Trial name
- CROSSYS (NCT03730610)
- Testing
- Exercise training
- Where
- Finland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Turku
Obesity, Diastolic Dysfunction
Changes in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic Function
The goal of this observational study is to learn if weight loss surgery can lower fat inside the heart muscle and improve how the heart relaxes in adults with obesity.
- Conditions
- Obesity, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- NCT07565610
- Volunteers
- 150 people
- Sponsor
- Itshak Amsalem
Obesity Hypoventilation Syndrome (OHS)
Evaluation of Upper Extremity Functions in Obesity Hypoventilation Syndrome Patients
Obesity Hypoventilation Syndrome (OHS) is a disease characterized by daytime hypercapnia and sleep-related respiratory disturbances in individuals with a body mass index (BMI) greater than 30 kg/m², without any other condition…
- Trial name
- NCT06766110
- Testing
- Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul University - Cerrahpasa
Hypertriglyceridemia, Overweight , Obesity
Standardized Large Yellow Tea Extract for Glucose and Lipid Metabolism in Overweight Adults With Hypertriglyceridemia
This multicenter, prospective, randomized, blinded, parallel-group controlled trial will evaluate the effects of standardized large yellow tea extract on glucose and lipid metabolism in overweight adults with elevated…
- Trial name
- NCT07840846
- Testing
- Standardized Large Yellow Tea Extract
- Volunteers
- 138 people
- Sponsor
- The First Affiliated Hospital of China University of Science and Technology (Anhui Provincial)
Obesity
A Mediterranean-style Breakfast and Postprandial Lipid Disorders in Obese Pre-adolescents and Adults
Obesity has a major impact on the development of cardiovascular disease and other related conditions and it is of particular concern in children.
- Trial name
- NCT01518803
- Testing
- Mediterranean-style breakfast, Western-style breakfast
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Obesity, Morbid, Surgery
Sleeve Versus Bypass in Older Patients: a Randomized Controlled Trial
The aim of the study is to compare two different bariatric procedures performed in patients with 65 years or more: gastric bypass and sleeve gastrectomy.
- Conditions
- Obesity, Morbid, Surgery, Elderly
- Trial name
- BaSE (NCT03339791)
- Testing
- Sleeve Gastrectomy, Gastric Bypass
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
Obesity, Insulin Resistance
Role of Adipose Tissue in Pathogenesis of Insulin Resistance
The aim of the study was to investigate the relationship between insulin resistance and body composition in relation to secterion and expression of adipocytokines.
- Trial name
- NCT00439491
- Testing
- Hypocaloric diet
- Where
- Czechia
- Volunteers
- 35 people
- Sponsor
- Charles University, Czech Republic
Infertility, Obesity
Use of Pulsatile Intravenous FSH to Mitigate Reprometabolic Syndrome
Hypothesis: The investigators hypothesize that pulsatile FSH intravenous administration to women with obesity will correct the Reprometabolic Syndrome (RMS) luteal deficiency phenotype.
- Conditions
- Infertility, Obesity, Diminished Ovarian Reserve (DOR), Diminished Ovarian Reserve
- Trial name
- NCT06414096
- Testing
- Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Endoscopic Sleeve Gastroplasty / Endoscopic Sleeve Gastroplasty
This will be a prospective, registry study of an investigational procedure for at least 12 standard of care visits up to 1 year after subject consents for study. Subjects will be enrolled between 8/1/2018 and 8/1/2023.
- Trial name
- NCT04640688
- Testing
- Bariatric procedures
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Methodist Health System
Obesity Adult Onset
Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses to Exercise in Obese Males
It was demonstrated that acute dietary supplementation with GSE reduced arterial blood pressure via reduction in Q in obese individuals.
- Trial name
- NCT04465110
- Testing
- Grape Seed Extract
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Pre-diabetes, Obese
Investigation of an Amino Acid Supplement on Glucose Levels in Obese Subjects
This study aims to determine whether the use of Branched-Chain Amino Acids (BCAA's) regulate insulin and glucagon secretion, and whether the supplement has any effect on body weight and body composition.
- Conditions
- Pre-diabetes, Obese, Glucose Intolerance
- Trial name
- NCT03715010
- Testing
- BCAA
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Overweight and Obesity, Pediatric Obesity
Evaluating the Feasibility of a Stepped-care Approach to Treating Adolescents With Binge and Loss of Control Eating
There are limited evidence-based treatments for adolescents with binge eating and fewer specifically targeting adolescents with both binge eating and overweight/obesity.
- Conditions
- Overweight and Obesity, Pediatric Obesity, Eating, Binge
- Trial name
- NCT03404713
- Testing
- Pathways to Health, Be4U
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
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