Clinical trials: Obesity, Overweight
Primary Prevention
ProSALUTE: Community Program for Cardiovascular Health
The purpose of this study is to determine the efficacy and cost/effectiveness (change in CV risk factors and lifestyle vs costs) of ProSALUTE as a new organizational model of primary CV prevention.
- Trial name
- ProSALUTE (NCT03129165)
- Testing
- Screening and prevention of CVD
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Centro Cardiologico Monzino
Morbid Obesity
Clinical and Health Economic Impact of Robot-assisted Surgery vs Conventional Laparoscopy : the Case of Gastric Bypass
The purpose of this study is to gather clinical and economic evidence on the use of robotics for bariatric surgery (gastric bypass).
- Trial name
- NCT01760512
- Testing
- Gastric bypass
- Where
- France
- Volunteers
- 118 people
- Sponsor
- IHU Strasbourg
Obesity, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities
The main purpose of this phase 3b study is to evaluate the efficacy and safety of tirzepatide compared with semaglutide in adult participants who have obesity or overweight with weight related comorbidities without Type 2…
- Trial name
- SURMOUNT-5 (NCT05822830)
- Testing
- Tirzepatide, Semaglutide
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 751 people
- Sponsor
- Eli Lilly and Company
Obesity, Roux-en-y Anastomosis Site
FundoRing Roux-en-Y Gastric Bypass Versus FundoRing One Anastomosis Gastric Bypass
Metabolic and bariatric surgery (MBS) is an effective and durable treatment of severe obesity and its co-morbidities. Gastric bypass is one of the main MBS procedures and is performed using various surgical techniques.
- Conditions
- Obesity, Roux-en-y Anastomosis Site, Reflux Gastritis, Reflux Esophagitis
- Trial name
- FundoRing_RY (NCT07486765)
- Testing
- Laparoscopic FundoRing gastric bypass
- Where
- Kazakhstan
- Volunteers
- 200 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Adipose Tissue
The Influence Of GIP (Glucose-Dependent Insulinotropic Polypeptide) Infusion On Human Adipose Tissue: An In Vivo Study
Study part-1 GIP (glucose-dependent insulinotropic polypeptide) is one of the two main incretin hormones secreted by specialized cells of the gastrointestinal tract in response to ingestion of nutrients.
- Trial name
- NCT00809029
- Testing
- GIP (glucose dependent insulinotropic peptide) infusion
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Sleep Apnea, Obstructive, Hypoxia
"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"
The purpose of this study is to determine the factors that are associated with improved cardiovascular function with the use of CPAP therapy on subjects diagnosed with moderate to severe obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive, Hypoxia, Hypercapnia, Sleep Disorders
- Trial name
- NCT01317329
- Testing
- Clinically prescribed CPAP therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Infertility, Obesity
Weight Management Intervention for Obese Women and the Live Birth Outcome of in Vitro Fertilization (IVF)
The primary aim of the study is to evaluate if weight management intervention for obese women (BMI≥30<35 kg/m2) prior to IVF improves the outcome assessed as live birth per participating woman, as compared to women where no…
- Trial name
- NCT01566929
- Testing
- Low calorie diet treatment
- Where
- 9 sites in Denmark, Iceland and 1 more
- Volunteers
- 317 people
- Sponsor
- Sahlgrenska University Hospital
C.Delivery; Penetration, Pregnant Uterus, by Instrument, Obesity
Cesarean Wound Closure in Women With BMI 40 or Greater
The purpose of this randomized controlled prospective trial is to guide physicians on the most effective evidenced based skin closure during a cesarean section for the obese gravida, defined as a BMI of 40 or greater.
- Trial name
- NCT02549131
- Testing
- Randomizing to Suture or Staple closure of Cesarean section
- Where
- 2 sites in United States
- Volunteers
- 232 people
- Sponsor
- Pediatrix
Cardiopathy, Diabetes
Diabetic/Metabolic Cardiomyopathy: Prevalence and Phenotype
"Little is known about the prevalence, determinants and phenotypes of the cardiomyopathy associated with diabetes and/or metabolic syndrome.
- Conditions
- Cardiopathy, Diabetes, Metabolic Syndrome
- Trial name
- METAB-HEART (NCT05181631)
- Testing
- Biobanking
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spinal Cord Injuries, Obesity
Telenutrition for Individuals With SCI
This study will provide nutrition counseling via FaceTime on an iPad to persons with traumatic spinal cord injury (SCI) who are overweight or obese and are at least one-year post-injury.
- Conditions
- Spinal Cord Injuries, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT05468437
- Testing
- Telenutrition
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Santa Clara Valley Health & Hospital System
Cardiovascular Disease, Insulin Resistance
A Trial of Tadalafil and Glycemic Traits
The purpose of this study is to find out if tadalafil can help overweight and obese people metabolize blood sugar more efficiently.
- Conditions
- Cardiovascular Disease, Insulin Resistance, Glucose Intolerance, Obesity
- Trial name
- NCT01444651
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Thomas J. Wang, MD
Obesity
Test of an Intervention to Increase Physical Activity Among School Children
The specific aims of this study are to: 1) evaluate the impact of a novel intervention delivered via school-based physical education (PE) on adolescents who have a high sensitivity to exercise-induced negative affect; 2)…
- Trial name
- NCT01876602
- Testing
- feeling states exercise intervention
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Obesity, Physical Activity
Leisure Time Activity and Nutrition Program
The purpose of this investigation is to conduct an 8-week pilot study to examine the effects of two different leisure-time activity prescriptions on dietary intake, leisure-time activities, and weight loss in 26 adults receiving…
- Trial name
- LEAN (NCT00656045)
- Testing
- Dietary, Physical Activity, TV Watching
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Obesity, Healthy
Sphingo-lipotoxicity and Trans-differentiation of Adipose Tissue in Obesity (SFINGOTRANS)
After recruiting a population of subjects with different metabolic severity (subjects of normal weight and obese patients with and without metabolic syndrome), the objectives of the present research will be: 1.
- Trial name
- SFINGOTRANS (NCT05761145)
- Testing
- Blood sample collection
- Where
- Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Chronic Disease, Hypertension
Rehabilitation in Primary Care: A Project to Maximize the Health Status of Adults With Chronic Illness
The purpose of the study is to determine whether occupational therapy and physiotherapy delivered in a primary care setting to adults with chronic illness is effective in improving health.
- Conditions
- Chronic Disease, Hypertension, Back Pain, Obesity
- Trial name
- NCT00229957
- Testing
- Occupational therapy, Physiotherapy, Self-management
- Where
- Canada
- Volunteers
- 303 people
- Sponsor
- Hamilton Health Sciences Corporation
Obesity, Childhood
Cleveland Clinic Families Get Fit (CCFit) : A Family-based Activity-Monitor Intervention in Pediatric Obesity
This is a randomized prospective study to evaluate the effectiveness of a family-based intervention using activity-monitors (I.e.
- Trial name
- CCFit (NCT04312919)
- Testing
- Family Based Activity Intervention
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- The Cleveland Clinic
Obesity & Overweight
Microrandomized Trial to Optimize Use of Burden-reducing Self-monitoring Approaches in Behavioral Obesity Treatment
This clinical trial is focused on testing dietary self-monitoring strategies used in behavioral obesity treatment. The goal is to determine which self-monitoring strategies are most useful for whom, at which points in treatment…
- Trial name
- NCT07228130
- Testing
- Online Behavioral Obesity Treatment, Full Dietary Self-monitoring, Reduced-frequency Dietary Self-monitoring
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- The Miriam Hospital
Overweight, Family Relations
Reducing Obesity Health Disparities in Hispanic Youth
The proposed study will evaluate the efficacy of a family-based obesity prevention intervention in increasing physical activity and improving the quality of dietary intake among Hispanic Youth.
- Conditions
- Overweight, Family Relations, Adolescent Behavior, Drug Use
- Trial name
- NCT03943628
- Testing
- Familias Unidas
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Miami
Metabolism and Nutrition Disorder, Obesity
Safety, Efficacy, Tolerability and Pharmacokinetics of NNC 0070-0002-0182 in Overweight or Obese Male and Female Volunteers
This trial will be conducted in the United States of America (USA). The aim of the trial is to investigate whether the drug is safe, well tolerated and to investigate the efficacy of NNC 0070-0002-0182 for the treatment of…
- Trial name
- NCT00665665
- Testing
- NNC 0070-0002-0182
- Where
- 2 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Hypertension
Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker
It is supposed that the significant metabolic effects (improvement of insulin sensitivity) of hypertension therapy with renin-angiotensin system (RAS) blockers in humans are mediated mainly via changes in abdominal adipose…
- Trial name
- ADIRAS (NCT01444833)
- Testing
- Candesartan
- Where
- Slovakia
- Volunteers
- 35 people
- Sponsor
- Slovak Academy of Sciences
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