Clinical trials: Obesity, Overweight
Transplant-Related Disorder, Overweight and Obesity
Nutrigenomics, Overweight/Obesity and Weight Management Trial (NOW Trial)
The investigators hypothesize that compared to the provision of population-based lifestyle advice, providing DNA-based lifestyle advice via personalized nutrigenomics testing (PNT) to two distinct patient populations (Family…
- Trial name
- NOW (NCT03015012)
- Testing
- Personalized Nutrigenomics Testing (PNT), Standard Nutrition Intervention (SNI)
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Western University, Canada
Hypertension, Sleep Apnea Syndromes
Fat Gain and Cardiovascular Disease Mechanisms
Understanding the mechanisms of obesity-induced hypertension is important both for prevention and therapy. Studies of patients with established obesity have provided valuable information on pathophysiologic links between obesity…
- Conditions
- Hypertension, Sleep Apnea Syndromes, Obesity
- Trial name
- NCT00589498
- Testing
- 1000 extra calories
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Overweight or Obesity
A Phase 1 Study to Evaluate EMP22 PD and EMP16 PK Versus Xenical® in Healthy Volunteers
This Phase I, active-controlled, randomised trial will be conducted in 2 parts. Part I aims to confirm the PD equivalence of EMP22 and Xenical® based on percent fecal fat excretion at steady state.
- Trial name
- NCT06013163
- Testing
- Xenical® vs EMP 22, EMP 22 vs Xenical®, EMP 16 vs Xenical®
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Empros Pharma AB
Obstructive Sleep Apnea of Adult, Obesity
Cost-effectiveness Study of a Lifestyle Change Program for the Treatment of OSA and Obesity: Hospital-Primary Care.
Obesity is the main risk factor for Obstructive Sleep Apnea (OSA). Nasal CPAP is the standard treatment for OSA, but since weight-loss programs are not usually offered to OSA patients, the root causes of their illness and its…
- Conditions
- Obstructive Sleep Apnea of Adult, Obesity, Lifestyle, Weight Loss
- Trial name
- SPP-1 (NCT04296721)
- Testing
- Intensive weigh-loss program, Standard Dietary recommendations
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitari de Bellvitge
Overweight, Obesity
A Master Protocol for Semaglutide Effects on Cardiovascular and Obesity-related Outcomes in People With Overweight or Obesity in the Real World
This study aims to evaluate the association of once-weekly semaglutide with the risk of cardiovascular (CV) and other obesity-related clinical outcomes in three study populations (Heart failure (HF), clinical Atherosclerotic…
- Conditions
- Overweight, Obesity, Heart Failure (HF), Atherosclerotic Cardiovascular Disease (ASCVD)
- Trial name
- NCT07141914
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 285,327 people
- Sponsor
- Novo Nordisk A/S
Chronic Ischemic Heart Disease, Obesity
Results of Coronary Artery Bypass Grafting in Obese Patients
This study is planned to assess the effect of obesity (BMI over 30 kg / m2) on hospital outcomes of isolated coronary artery bypass grafting in patients with chronic ischemic heart disease.
- Trial name
- NCT04916912
- Testing
- coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Obesity, Diet Modification
Metabolic Impact of Time Restricted Feeding
The investigators are interested in how time-restricted feeding will impact weight, sleep duration and efficacy, and activity levels in obese adults.
- Trial name
- NCT03129581
- Testing
- Dietary Counseling
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity
Safety, Tolerability and Efficacy Study of PP1420 in HV
Obesity is a growing pandemic which affects 1 in 4 adults in the UK, and shortens life by increasing cardiovascular disease, diabetes and cancer.
- Trial name
- PP14201b1c (NCT02221765)
- Testing
- PP1420
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Schizophrenia, Schizoaffective Disorder
MEtformin and Lorcaserin for WeighT Loss in Schizophrenia
Purpose: The purpose of this study is to test new pharmacologic strategies for weight loss in patients with schizophrenia, a population for which no current weight-loss treatments have gained widespread use.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Overweight
- Trial name
- MELT (NCT02796144)
- Testing
- Lorcaserin, Metformin
- Where
- 4 sites in United States
- Volunteers
- 71 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension, Obesity
Effectiveness of Avapro in Obese Normotensive/Hypertensive African Americans
The purpose of this study is to test the hypothesis that hypertension increases the anti-natriuretic effects of an angiotensin receptor antagonist during mental stress in overweight/obese African-American's who retain sodium…
- Conditions
- Hypertension, Obesity, Stress, Psychological, Blood Pressure
- Trial name
- Avapro3 (NCT02386293)
- Testing
- Irbesartan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS)
Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation
To evaluate the safety and effectiveness of the Automatic Expiratory Positive Airway Pressure (Auto-EPAP) feature versus manual expiratory positive airway pressure (EPAP) in the Vivo 45 LS Ventilator.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Diseases (NMD)
- Trial name
- Vivo NOVA (NCT06560411)
- Testing
- Non-Invasive Ventilation
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Breas Medical, Inc.
Aging, Obesity
Lifestyle Intervention to Improve Bone Quality
Obese older adults will be randomized to participate in either healthy lifestyle intervention or behavioral diet and exercise intervention for one year.
- Trial name
- LIMB-Q (NCT03329963)
- Testing
- Healthy Lifestyle Intervention, Lifestyle Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Baylor College of Medicine
Obesity, Healthy Aging
Sukalmena InAge: Nutritional-culinary Programme to Promote Adherence to a Healthy Dietary Pattern.
Currently, one of the main health challenges of public health is to improve the quality of life of people with chronic non-communicable diseases, through new strategies that promote healthy eating habits and lifestyles.
- Conditions
- Obesity, Healthy Aging, Cognitive Impairment
- Trial name
- Sukalmena (NCT04908163)
- Testing
- Mediterranean diet-based nutritional education intervention, Mediterranean diet-based culinary intervention
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Basque Culinary Center Fundazioa
Diet, Healthy, Obesity
FEAST Perinatal Support Program Intervention
Latino individuals face an elevated risk of adverse health outcomes during pregnancy, impacting both the birthing parent and the baby with potential long-term chronic health conditions.
- Conditions
- Diet, Healthy, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT06715787
- Testing
- FEAST Perinatal Support Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Intubation;Difficult, Obesity, Morbid
Pre-Operative Airway Assessment of Patients With Morbid Obesity
Backround:The incidence of difficulty in laryngoscopy and endotracheal intubation is more common in obese patients. There are conflicting data on factors predicting difficult intubation.
- Trial name
- NCT04542187
- Where
- Turkey (Türkiye)
- Volunteers
- 121 people
- Sponsor
- Bagcilar Training and Research Hospital
Overweight, Obese
Effects of Long Term Calorie Restriction on Sphingomyelin and Amino Acids
The effect of weight loss with long-term low calorie diet (LCD) on plasma metabolites is unknown. The aim was to examine whether a LCD-induced weight reduction results in changes in the extended plasma metabolites.
- Trial name
- NCT02081898
- Testing
- LCD
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Obesity
BEYOND Weight Loss Maintenance Study
A study to determine the effectiveness of two weight loss maintenance interventions in Counterweight Plus, a structured weight management programme.
- Trial name
- NCT02683798
- Testing
- Continuous energy restriction, Intermittent energy restriction
- Where
- 3 sites in United Kingdom
- Volunteers
- 63 people
- Sponsor
- NHS Greater Glasgow and Clyde
Obesity, Insulin Resistance
The Importance of the Gut Microbiota in Body Weight Control and Insulin Sensitivity
BACKGROUND: The relation between gut microbiota and obesity originates from animal studies, showing that the change of gut microbiota can induce changes in both insulin resistance and body composition.
- Trial name
- ANTIBIOTICS (NCT02241421)
- Testing
- Amoxicillin, Vancomycin
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- Maastricht University Medical Center
Pediatric Obesity, Executive Function
Cognitive Aspects of Response to Treatment for Weight-related Health to Improve Eating and Exercise Earlier in Life
We plan to examine whether child and parental cognitive/executive function predict body composition outcomes and adherence to a 6-month protocol of Family-Based Behavioral Treatment (FBT), for pediatric obesity.
- Trial name
- CARTWHEEL (NCT03329300)
- Testing
- Family-based Behavioral Treatment (FBT)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Alabama at Birmingham
PreDiabetes, Obesity
Effect of Mango Consumption on Individuals with Pre-diabetes
This study is designed to explore the effect of mango consumption on glycemic indices, cardiovascular health, and body composition in overweight and obese individuals with prediabetes.
- Trial name
- NCT05571800
- Testing
- Mango
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Florida State University
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