Clinical trials: Obesity, Overweight
Obesity, Bariatric Surgery
Impact of Weight Loss After a Bypass Surgery on Renal Hemodynamic Under Stress Conditions
The sympathetic nervous (SNS) and the renin angiotensin aldosterone system (RAS) have a direct impact on renal hemodynamic, hormonal secretion and vasoactive peptide.
- Conditions
- Obesity, Bariatric Surgery, Blood Pressure
- Trial name
- OBBYSS (NCT02218112)
- Testing
- bariatric surgery (gastric bypass)
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Obesity
EFFICACY OF THE SLEEVE GASTROPLASTY WITH THE ENDOSCOPIC SYSTEM OVERSTICH SX ON WEIGHT LOSS AND REDUCTION OF CO-MORBIDITY FOR OBESE PATIENTS
The OverStitch ™ Sx System (Apollo Endosurgery Inc., Austin, Tx, Usa) is a new generation of endoscopic suturing device. It is inserted into an endoscope allowing the approximation of Luc Karsentys soft tissue by placement of…
- Trial name
- SLEEVE (NCT05072067)
- Testing
- the sleeve gastroplasty with the endoscopic system Overstich SX
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Clinique du Trocadéro
Diabetes, Diabetes Mellitus, Type 2
Comparison of the Change in Fat Distribution in Overweight and Obese Subjects With Type 2 Diabetes After Insulin Treatment
This trial is conducted in Europe. The aim of this clinical trial is to compare the change in trunk fat mass, assessed by Double Energy X-ray Absorptiometry (DEXA) after 26 weeks of treatment with insulin detemir or insulin NPH…
- Trial name
- NCT00795600
- Testing
- insulin detemir, insulin NPH
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Novo Nordisk A/S
Obesity
Pilot Study of Dietary Modification of Appetite Set Point in Obesity
An innovative dietary approach to obesity, based on the set-point theory of body weight and associative learning, was developed by Seth Roberts.
- Trial name
- NCT00726271
- Testing
- light olive oil, fish oil capsules, flax seed oil capsules
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- State University of New York - Upstate Medical University
Sleep Apnea Syndrome
Validation of Apnea LinkTM for Sleep Apnea Syndrome Screening in a Bariatric Population
Sleep apnea syndrome (OSA) frequently occurs in obese population undergoing bariatric surgery. There is a need for alternative screening tools for sleep apnea detection in the pre-operative period.
- Trial name
- NCT01354756
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Periodontitis, Obesity
EVALUATION of GINGIVAL CREVICULAR FLUID and SERUM ASPROSIN LEVELS in OBESE and NORMAL-WEIGHT INDIVIDUALS with PERIODONTITIS
Obesity and periodontitis are chronic inflammatory diseases that share common pathological mechanisms. Asprosin, a novel adipokine discovered in 2016, has not been extensively studied in relation to periodontal tissues.
- Trial name
- NCT06879951
- Testing
- Participants are not assigned an intervention as part of the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Overweight or Obesity, Obesity, Abdominal
Hypocaloric Mediterranean Diet or Physical Activity to Lower Cardiometabolic Risk
The purpose of this randomized controlled trial is to test the effects of a hypocaloric Mediterranean diet or of physical activity in participants who take at least 2 antihypertensive drugs but do not reach blood pressure…
- Conditions
- Overweight or Obesity, Obesity, Abdominal, Hypertension
- Trial name
- MeDiPA (NCT04155112)
- Testing
- Physical activity, Hypocaloric Mediterranean diet
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Oslo University Hospital
Obesity, Metabolic Syndrome
Effects of Pre-exercise Carbohydrate Restriction Relative to Fasting on Metabolism, Appetite, and Energy Intake in Healthy Males.
This study will compare the metabolic, appetite, energy intake, and perceptual responses to a bout of exercise completed in the evening after after a low-carbohydrate lunch meal (<10% carbohydrate content / 0.2 g/kg carbohydrate…
- Trial name
- NCT05107583
- Testing
- Low-Carbohydrate Pre-Exercise Meal, High-Carbohydrate Pre-Exercise Meal, Fasted Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Metabolic Disease, Obesity
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System
Background: Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels.
- Conditions
- Metabolic Disease, Obesity, Li-Fraumeni Syndrome, Cardiomyopathy
- Trial name
- NCT01143454
- Testing
- NSR IDE-MRI: Research pulse sequences
- Where
- 3 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Incentives
A Randomized Incentive-Based Weight Loss Trial in Singapore
The purpose of this study is to test the extent to which incentives, when combined with an existing evidence-based weight loss program, improve weight loss and weight loss maintenance.
- Trial name
- NCT01533454
- Testing
- Financial Incentives
- Where
- Singapore
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Overweight, Diabetes
Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects w/o Type 2 Diabetes
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects without or with Type 2 Diabetes
- Conditions
- Overweight, Diabetes, PreDiabetes, Obesity
- Trial name
- LIGHT-UP (NCT03058029)
- Testing
- Gelesis200
- Where
- 30 sites in United States, Canada and 6 more
- Volunteers
- 300 people
- Sponsor
- Gelesis, Inc.
Achalasia, Esophageal
Metabolic Changes Associated With Weight Gain After Treatment of Achalasia
This goal of the study is to assess the effect of weight gain in patients with achalasia after they are treated. The main question to be answered is if weight gain after achalasia treatment is associated with worsening metabolic…
- Trial name
- NCT07334639
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Bypass Complications
Sustained-release Morphine Pharmacokinetics in Roux-en-Y Gastric Bypass Subjects
The purpose of this study is to determine whether sustained release morphine pharmacokinetics parameters in patients undergone roux-en-y gastric bypass (RYGB) differ from subjects who did not.
- Trial name
- OBEMO2 (NCT02641301)
- Testing
- Sustained release morphine sulfate, 30 mg
- Where
- 2 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hopital Lariboisière
Steatosis of Liver, Metabolic Liver Injury
Non-Invasive Hepatic and Metabolic Index Changes After Incretin Therapy in Overweight/Obesity
This single-center, retrospective observational cohort study evaluated early changes in non-invasive hepatic and metabolic indices (FIB-4, APRI, HSI, and the triglyceride-glucose [TyG] index) in adults with overweight or obesity…
- Conditions
- Steatosis of Liver, Metabolic Liver Injury, Obesity, Overweight
- Trial name
- GLP-NIT (NCT07701005)
- Testing
- Semaglutide, Tirzepatide
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Goztepe Prof Dr Suleyman Yalcın City Hospital
Childhood Overweight and Obesity Immersive Physical Activity
Immersive Physical Activity Program for Overweight Schoolchildren
Childhood overweight and obesity are major public health concerns associated with increased cardiometabolic risk and reduced quality of life.
- Trial name
- PEESO (NCT07681856)
- Testing
- RVI_Experimental_Immersive Virtual Reality Exergame Program, RVI_ControGroup_Immersive Virtual Reality Exergame Program
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- University of Vigo
Liposuction, Obesity
Wetting Solution-ideal Body Weight Ratio in Liposuction Procedures
Although the use of wetting solutions during high-volume liposuction is a standard approach, it is unclear how to optimize wetting solutions and components and their effect on postoperative complications..
- Conditions
- Liposuction, Obesity, Postoperative Complications
- Trial name
- NCT06260501
- Testing
- super-wet technique
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Acibadem University
Overweight and Obesity
The Alberta FYBER (Feed Your Gut Bacteria morE fibeR) Study
Too much body-fat has been linked to a low-grade inflammation throughout the body. This inflammation is thought to then cause different diseases, like heart disease and diabetes.
- Trial name
- NCT02322112
- Testing
- Microcrystalline Cellulose Supplementation, Acacia Gum Supplementation, Resistant Starch Type 4 Supplementation
- Where
- Canada
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obesity, Eating Behaviour
The Effect of Neurofeedback on Eating Behaviour
Neuroimaging is becoming increasingly common to investigate the neural networks underlying eating behaviour and food preference in normal-weight and obese humans.
- Trial name
- NCT02148770
- Testing
- Neurofeedback
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Child Obesity
YES! We Can PLAY: A Physical Activity and Nutrition After-School Program for Middle School Students
YES! We can PLAY: A Physical Activity and Nutrition After-School Program for Middle School Students, is a collaborative partnership between the University of Alabama at Birmingham and the Birmingham City Schools District to…
- Trial name
- NCT04132869
- Testing
- Sports Readiness Intervention
- Where
- 2 sites in United States
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Heart Diseases
Anger and Cardiovascular Risk in Urban Youth
To examine anger and cardiovascular disease risk in urban youth. The project studied patterns of hemodynamic responses to social and nonsocial stressors, ambulatory blood pressure (BP), fasting insulin, fasting glucose, lipid…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Obesity
- Trial name
- NCT00005383
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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