Clinical trials: Obesity, Prediabetes
Pre-Diabetes, Weight, Body
Prevention of Progression of Prediabetes, Obesity and CV Risk
The investigators are studying how to help people with prediabetes (Pre-DM) and obesity. The goal is to use new and affordable treatments to bring blood sugar levels back to normal and help participants to lose weight.
- Conditions
- Pre-Diabetes, Weight, Body, Cardiovascular Diseases
- Trial name
- Pre-DM (NCT06446531)
- Testing
- Rybelsus Tablet, Jardiance 25Mg Tablet, Metformin
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
GDM, Insulin Resistance
In Vitro Fertilization Impact on Metabolic Parameters
A quantitative prospective cohort study will be conducted, where blood samples will be collected at different timings during the IVF protocol, to assess the impact of fertility medications on metabolic parameters of patients…
- Conditions
- GDM, Insulin Resistance, Glucose Intolerance, PCOS
- Trial name
- IVF (NCT03426228)
- Testing
- HbA1C
- Where
- United Arab Emirates
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Cardiovascular Disease, Insulin Resistance
A Trial of Tadalafil and Glycemic Traits
The purpose of this study is to find out if tadalafil can help overweight and obese people metabolize blood sugar more efficiently.
- Conditions
- Cardiovascular Disease, Insulin Resistance, Glucose Intolerance, Obesity
- Trial name
- NCT01444651
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Thomas J. Wang, MD
Cardiovascular Risk Factor, Prediabetes
Active You: A Novel Exercise Program for African Americans
Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04280783
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
PreDiabetes, Obesity
Dinner Time for Obesity and Prediabetes
Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity.
- Conditions
- PreDiabetes, Obesity, Healthy
- Trial name
- DTOP (NCT05745441)
- Testing
- Early Dinner, Late Dinner, Early Dinner tracer
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity, Metabolic Syndrome
CardioMetabolic Program Meets eHealth: Redesign and Evaluation for Optimal Reach and Impact
The eCMP Pilot aims to study the feasibility and potential effectiveness of an electronically-mediated CardioMetabolic Program (eCMP) for therapeutic lifestyle change among adults with or at high risk for type 2 diabetes, heart…
- Conditions
- Obesity, Metabolic Syndrome, Pre-diabetes, Type 2 Diabetes
- Trial name
- eCMP (NCT02246400)
- Testing
- eCMP
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Palo Alto Medical Foundation
Obese, Weight Loss
Efficacy of Henagliflozin for Weight Loss in Obesity Without Diabetes
This trial is conducted in China. The purpose of the 24-week trial is to investigate the efficacy of henagliflozin to induce body weight loss and the purpose of the extension is to evaluate the hypoglycemic effect of…
- Conditions
- Obese, Weight Loss, Pre-diabetes
- Trial name
- NCT06216340
- Testing
- Henagliflozin
- Volunteers
- 300 people
- Sponsor
- The First People's Hospital of Changzhou
Prediabetes / Type 2 Diabetes, Obesity and Overweight
An Integrative Study of the Role of Microbiome, Metabolome, Transcriptome and Chronobiology in the Context of Type 2 Diabetes.
The goal of this descriptive clinical study is to investigate daily oscillations in glycaemic control between healthy adults and adults with excess weight and who have early-stage prediabetes or T2D and are not taking medications…
- Conditions
- Prediabetes / Type 2 Diabetes, Obesity and Overweight, Insulin Resistance
- Trial name
- KRONODIABET (NCT06783218)
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Pre Diabetes, Diabetes
Metabolic Response Evaluation of Low-sugar Snack Bars
To determine the post-prandial metabolic response and biomarker response, following the consumption of newly developed low glycaemic index (GI) snack bars.
- Conditions
- Pre Diabetes, Diabetes, Obesity
- Trial name
- NCT04653220
- Testing
- Control 1, Control 2, Standard Crokao
- Where
- Singapore
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Obesity, Pregnancy in Diabetic
Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes
The obesity epidemic is growing worldwide and in the UK this is perpetuated with a third of women classified as overweight/obese in 2020.
- Conditions
- Obesity, Pregnancy in Diabetic, Pregnancy Complications, Pregnancy Related
- Trial name
- NCT05753124
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease
The purpose of this study is to understand the role of GLP-1 in the pathogenesis of T2D in youth and explore their potential salutary effects and ability to delay the progressive loss of ß-cell function and reduce hepatic…
- Conditions
- Type 2 Diabetes Mellitus, Impaired Glucose Tolerance, Non-Alcoholic Fatty Liver Disease, Obesity, Childhood
- Trial name
- NCT05067621
- Testing
- Semaglutide Pen Injector
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 2, Pre-diabetes
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans
The rationale for the proposed research is that elucidating changes in localized diacylglycerol (DAG) and sphingolipid species that predict insulin sensitivity will reveal specific localized lipids to target in therapeutics for…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Obesity
- Trial name
- NCT03077360
- Testing
- Lifestyle
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Prediabetes, Gestational Diabetes
Treating Prediabetes in the First Trimester
The investigators plan to study a sample of women with prediabetes (diagnosed by Hemoglobin A1c (HbA1c) 5.7-6.4% or fasting plasma glucose (FPG) 92-125 mg/dL) in the first trimester of pregnancy, and patients will be randomized…
- Trial name
- NCT01926457
- Testing
- Treatment of Prediabetes
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Overweight, Diabetes
Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects w/o Type 2 Diabetes
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis200 on Body Weight in Overweight and Obese Subjects without or with Type 2 Diabetes
- Conditions
- Overweight, Diabetes, PreDiabetes, Obesity
- Trial name
- LIGHT-UP (NCT03058029)
- Testing
- Gelesis200
- Where
- 30 sites in United States, Canada and 6 more
- Volunteers
- 300 people
- Sponsor
- Gelesis, Inc.
PreDiabetes, Overweight and Obesity
Family Diabetes Prevention Program Pilot Study
This study will examine the feasibility and acceptability of a family-oriented augmentation of the Diabetes Prevention Program lifestyle intervention (DPP), called the Family DPP.
- Conditions
- PreDiabetes, Overweight and Obesity, Type 2 Diabetes, Overweight, Childhood
- Trial name
- NCT05358444
- Testing
- National Diabetes Prevention Program Lifestyle Intervention (DPP), Family Diabetes Prevention Program (Family DPP)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dyslipidemia, Diabetes
Meta-analyses of Fructose and Cardiometabolic Risk
Diabetes and heart associations continue to discourage high intakes of dietary fructose, a constituent part of the sucrose molecule that is found in fruits and vegetables as a natural sugar and in some processed foods and…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01363791
- Testing
- Dietary fructose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Prediabetic State, Insulin Resistance
Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes
Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this trial is to evaluate the effect of empagliflozin + linagliptin + metformin + lifestyle on…
- Trial name
- 4T (NCT04131582)
- Testing
- Linagliptin + metformin and Empagliflozin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Universidad de Guanajuato
Obesity, Insulin Resistance
The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
The primary aim of this study is to evaluate the effect of exenatide on daily glycemic excursions obtained by continuous glucose monitoring system (CGMS).
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00845559
- Testing
- Exenatide
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Obesity, Diabetes Mellitus
Inflammation, Diabetes, Ethnicity and Obesity Cohort
Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- IDEO (NCT03022682)
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetes, Prediabetes
Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet.
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01605422
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper